ID CXB2_MACMU Reviewed; 226 AA. AC Q8MIT8; DT 19-SEP-2003, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2002, sequence version 1. DT 16-JAN-2019, entry version 102. DE RecName: Full=Gap junction beta-2 protein; DE AltName: Full=Connexin-26; DE Short=Cx26; GN Name=GJB2; OS Macaca mulatta (Rhesus macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9544; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Orten D.J., Bizzarri-Kriener C., Askew J.W., Li J.-L., Louis E., RA Kelley P.M., Kimberling W.J.; RT "Sequence comparison of primate connexin 26 (GJB2) genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: One gap junction consists of a cluster of closely packed CC pairs of transmembrane channels, the connexons, through which CC materials of low MW diffuse from one cell to a neighboring cell. CC {ECO:0000250}. CC -!- SUBUNIT: A connexon is composed of a hexamer of connexins. CC Interacts with CNST (By similarity). {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass CC membrane protein {ECO:0000250}. Cell junction, gap junction CC {ECO:0000250}. CC -!- SIMILARITY: Belongs to the connexin family. Beta-type (group I) CC subfamily. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY046584; AAL03976.1; -; Genomic_DNA. DR RefSeq; NP_001038200.1; NM_001044735.1. DR RefSeq; XP_014976159.1; XM_015120673.1. DR RefSeq; XP_014976160.1; XM_015120674.1. DR UniGene; Mmu.10845; -. DR SMR; Q8MIT8; -. DR STRING; 9544.ENSMMUP00000013790; -. DR Ensembl; ENSMMUT00000014720; ENSMMUP00000013790; ENSMMUG00000010522. DR GeneID; 704224; -. DR KEGG; mcc:704224; -. DR CTD; 2706; -. DR eggNOG; ENOG410IFM8; Eukaryota. DR eggNOG; ENOG410Y7VN; LUCA. DR GeneTree; ENSGT00940000154215; -. DR HOGENOM; HOG000231127; -. DR HOVERGEN; HBG009576; -. DR InParanoid; Q8MIT8; -. DR KO; K07621; -. DR OMA; VMYDGFA; -. DR OrthoDB; 1043502at2759; -. DR TreeFam; TF329606; -. DR Proteomes; UP000006718; Chromosome 17. DR Bgee; ENSMMUG00000010522; Expressed in 12 organ(s), highest expression level in testis. DR ExpressionAtlas; Q8MIT8; baseline. DR GO; GO:0005922; C:connexin complex; IEA:InterPro. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005243; F:gap junction channel activity; IEA:Ensembl. DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl. DR GO; GO:0007267; P:cell-cell signaling; IEA:Ensembl. DR GO; GO:0016264; P:gap junction assembly; IEA:Ensembl. DR GO; GO:0007605; P:sensory perception of sound; IEA:UniProtKB-KW. DR Gene3D; 1.20.1440.80; -; 1. DR InterPro; IPR000500; Connexin. DR InterPro; IPR002268; Connexin26. DR InterPro; IPR019570; Connexin_CCC. DR InterPro; IPR017990; Connexin_CS. DR InterPro; IPR013092; Connexin_N. DR InterPro; IPR038359; Connexin_N_sf. DR PANTHER; PTHR11984; PTHR11984; 1. DR Pfam; PF00029; Connexin; 1. DR PRINTS; PR00206; CONNEXIN. DR PRINTS; PR01139; CONNEXINB2. DR SMART; SM00037; CNX; 1. DR SMART; SM01089; Connexin_CCC; 1. DR PROSITE; PS00407; CONNEXINS_1; 1. DR PROSITE; PS00408; CONNEXINS_2; 1. PE 3: Inferred from homology; KW Cell junction; Cell membrane; Complete proteome; Disulfide bond; KW Gap junction; Hearing; Membrane; Reference proteome; Transmembrane; KW Transmembrane helix. FT CHAIN 1 226 Gap junction beta-2 protein. FT /FTId=PRO_0000057857. FT TOPO_DOM 1 20 Cytoplasmic. {ECO:0000255}. FT TRANSMEM 21 40 Helical. {ECO:0000255}. FT TOPO_DOM 41 75 Extracellular. {ECO:0000255}. FT TRANSMEM 76 98 Helical. {ECO:0000255}. FT TOPO_DOM 99 131 Cytoplasmic. {ECO:0000255}. FT TRANSMEM 132 154 Helical. {ECO:0000255}. FT TOPO_DOM 155 192 Extracellular. {ECO:0000255}. FT TRANSMEM 193 215 Helical. {ECO:0000255}. FT TOPO_DOM 216 226 Cytoplasmic. {ECO:0000255}. FT DISULFID 53 180 {ECO:0000250}. FT DISULFID 60 174 {ECO:0000250}. FT DISULFID 64 169 {ECO:0000250}. SQ SEQUENCE 226 AA; 26224 MW; 1F4BAC3BB20D0528 CRC64; MDWGALQTIL GGVNKYSTSI GKIWLTVLFI FRIMILVVAA KEVWGDEQAD FVCNTLQPGC KNVCYDHYFP ISHIRLWALQ LIFVSTPALL VAMHVAYRRH EKKRKFIKGE IKNEFKDIEE IKTQKVRIEG SLWWTYTSSI FFRVVFEAAF MYVFYVMYDG FSMQRLVKCN AWPCPNTVDC FVSRPTEKTV FTVFMIAVSG ICILLNVTEL CYLLIRYCSG KSKKPV //