ID Q8LP73_9ROSI PRELIMINARY; PRT; 355 AA. AC Q8LP73; DT 01-OCT-2002 (TrEMBLrel. 22, Created) DT 01-OCT-2002 (TrEMBLrel. 22, Last sequence update) DT 01-MAR-2004 (TrEMBLrel. 26, Last annotation update) DE Leucoanthocyanidin dioxgenase. GN Name=KyLDOX1; OS Vitis labrusca x Vitis vinifera. OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; core eudicots; rosids; OC Vitaceae; Vitis. OX NCBI_TaxID=105599; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=22242703; PubMed=12355152; DOI=10.1007/s00425-002-0830-5; RA Kobayashi S., Ishimaru M., Hiraoka K., Honda C.; RT "Myb-related genes of the Kyoho grape ( Vitis labruscana) regulate RT anthocyanin biosynthesis."; RL Planta 215:924-933(2002). CC -!- FUNCTION: Oxidation of leucoanthocyanidins into anthocyanidins (By CC similarity). CC -!- CATALYTIC ACTIVITY: Leucocyanidin + 2-oxoglutarate + O(2) = cis- CC and trans-dihydroquercetins + succinate + CO(2). CC -!- COFACTOR: Binds 1 iron ion and one ascorbate molecule per subunit CC (By similarity). CC -!- PATHWAY: Flavonoid synthesis; anthocyanidins biosynthesis. CC -!- SIMILARITY: Belongs to the iron/ascorbate-dependent oxidoreductase CC family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB073018; BAC07545.1; -. DR HSSP; Q96323; 1GP6. DR GO; GO:0016491; F:oxidoreductase activity; IEA. DR GO; GO:0009813; P:flavonoid biosynthesis; IEA. DR InterPro; IPR005123; 2OG-FeII_Oxy. DR InterPro; IPR001261; ArgE_dapE. DR Pfam; PF03171; 2OG-FeII_Oxy; 1. DR PROSITE; PS00758; ARGE_DAPE_CPG2_1; UNKNOWN_1. KW Dioxygenase; Flavonoid biosynthesis; Iron; Metal-binding; KW Oxidoreductase; Vitamin C. SQ SEQUENCE 355 AA; 40193 MW; 89DB9459DF55A5A1 CRC64; MVTSVAPRVE SLSSSGIQSI PKEYIRPQEE LTSIGNVFEE EKKDEGPQVP TIDLKDIESE DEVVRERCRE ELKKAAMEWG VMHLVNHGIS DDLINRVKVA GETFFNLPME EKEKYANDQA SGKIAGYGSK LANNASGQLE WEDYFFHLIF PEDKRDMTIW PKTPSDYVPA TCEYSVKLRS LATKILSVLS LGLGLEEGRL EKEVGGMEEL LLQKKINYYP KCPQPELALG VEAHTDVSAL TFILHNMVPG LQLFYEGKWV TAKCVPNSII MHIGDTIEIL SNGKYKSILH RGLVNKEKVR ISWAVFCEPP KEKIILKPLP ETVSETEPPL FPPRTFSQHI QHKLFRKTQE ALLSK //