ID TKI1_ARATH Reviewed; 743 AA. AC Q8LJT8; Q3EBL6; Q8VZJ8; Q9SJL1; DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot. DT 09-JAN-2007, sequence version 2. DT 15-MAR-2017, entry version 114. DE RecName: Full=TSL-kinase interacting protein 1; DE AltName: Full=Myb-related protein TKI1; GN Name=TKI1; OrderedLocusNames=At2g36960; ORFNames=T1J8.14; OS Arabidopsis thaliana (Mouse-ear cress). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; OC Arabidopsis. OX NCBI_TaxID=3702; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), INTERACTION WITH TOUSLED, RP PHOSPHORYLATION, AND TISSUE SPECIFICITY. RC STRAIN=cv. Columbia; RX PubMed=15047893; DOI=10.1104/pp.103.038117; RA Ehsan H., Reichheld J.-P., Durfee T., Roe J.L.; RT "TOUSLED kinase activity oscillates during the cell cycle and RT interacts with chromatin regulators."; RL Plant Physiol. 134:1488-1499(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM 1). RC STRAIN=cv. Columbia; RX PubMed=10617197; DOI=10.1038/45471; RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., RA Moffat K.S., Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., RA Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., RA Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D., RA Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M., RA Venter J.C.; RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis RT thaliana."; RL Nature 402:761-768(1999). RN [3] RP GENOME REANNOTATION. RC STRAIN=cv. Columbia; RG The Arabidopsis Information Resource (TAIR); RL Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=cv. Columbia; RX PubMed=14593172; DOI=10.1126/science.1088305; RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., RA Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., RA Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G., RA Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., RA Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., RA Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., RA Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., RA Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., RA Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., RA Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., RA Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., RA Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.; RT "Empirical analysis of transcriptional activity in the Arabidopsis RT genome."; RL Science 302:842-846(2003). RN [5] RP INTERACTION WITH SNL1. RX PubMed=19962994; DOI=10.1016/j.jmb.2009.11.065; RA Bowen A.J., Gonzalez D., Mullins J.G., Bhatt A.M., Martinez A., RA Conlan R.S.; RT "PAH-domain-specific interactions of the Arabidopsis transcription RT coregulator SIN3-LIKE1 (SNL1) with telomere-binding protein 1 and RT ALWAYS EARLY2 Myb-DNA binding factors."; RL J. Mol. Biol. 395:937-949(2010). CC -!- SUBUNIT: Interacts only with active kinase forms of TOUSLED. CC Interacts with SNL1. {ECO:0000269|PubMed:15047893, CC ECO:0000269|PubMed:19962994}. CC -!- INTERACTION: CC Q39238:TOUSLED; NbExp=4; IntAct=EBI-2366507, EBI-2325484; CC -!- SUBCELLULAR LOCATION: Nucleus. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=Q8LJT8-1; Sequence=Displayed; CC Name=2; CC IsoId=Q8LJT8-2; Sequence=VSP_022229; CC Note=May be due to a competing acceptor splice site. No CC experimental confirmation available.; CC -!- TISSUE SPECIFICITY: Expressed in flowers, roots and leaves. CC {ECO:0000269|PubMed:15047893}. CC -!- DOMAIN: The Myb domain is not required for TOUSLED binding. CC -!- PTM: Phosphorylated in vitro by TOUSLED. CC {ECO:0000269|PubMed:15047893}. CC -!- SEQUENCE CAUTION: CC Sequence=AAD31581.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF530160; AAM94622.1; -; mRNA. DR EMBL; AC006922; AAD31581.1; ALT_SEQ; Genomic_DNA. DR EMBL; CP002685; AEC09326.1; -; Genomic_DNA. DR EMBL; CP002685; AEC09327.1; -; Genomic_DNA. DR EMBL; AY064068; AAL36424.1; -; mRNA. DR EMBL; AY096376; AAM20017.1; -; mRNA. DR PIR; G84786; G84786. DR RefSeq; NP_001318368.1; NM_001336615.1. [Q8LJT8-1] DR RefSeq; NP_850273.1; NM_179942.4. [Q8LJT8-1] DR UniGene; At.27079; -. DR ProteinModelPortal; Q8LJT8; -. DR BioGrid; 3614; 4. DR IntAct; Q8LJT8; 5. DR STRING; 3702.AT2G36960.3; -. DR SwissPalm; Q8LJT8; -. DR PaxDb; Q8LJT8; -. DR EnsemblPlants; AT2G36960.1; AT2G36960.1; AT2G36960. [Q8LJT8-1] DR EnsemblPlants; AT2G36960.2; AT2G36960.2; AT2G36960. [Q8LJT8-1] DR GeneID; 818270; -. DR Gramene; AT2G36960.1; AT2G36960.1; AT2G36960. DR Gramene; AT2G36960.2; AT2G36960.2; AT2G36960. DR KEGG; ath:AT2G36960; -. DR Araport; AT2G36960; -. DR eggNOG; KOG4468; Eukaryota. DR eggNOG; ENOG4111TCZ; LUCA. DR HOGENOM; HOG000239895; -. DR InParanoid; Q8LJT8; -. DR PhylomeDB; Q8LJT8; -. DR PRO; PR:Q8LJT8; -. DR Proteomes; UP000006548; Chromosome 2. DR ExpressionAtlas; Q8LJT8; baseline. DR Genevisible; Q8LJT8; AT. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW. DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW. DR Gene3D; 1.10.10.60; -; 1. DR InterPro; IPR009057; Homeobox-like. DR InterPro; IPR001005; SANT/Myb. DR InterPro; IPR017884; SANT_dom. DR Pfam; PF00249; Myb_DNA-binding; 1. DR SMART; SM00717; SANT; 1. DR SUPFAM; SSF46689; SSF46689; 1. DR PROSITE; PS51293; SANT; 1. PE 1: Evidence at protein level; KW Alternative splicing; Complete proteome; DNA-binding; Nucleus; KW Phosphoprotein; Reference proteome; Transcription; KW Transcription regulation. FT CHAIN 1 743 TSL-kinase interacting protein 1. FT /FTId=PRO_0000270796. FT DOMAIN 53 104 SANT. {ECO:0000255|PROSITE- FT ProRule:PRU00624}. FT VAR_SEQ 286 287 Missing (in isoform 2). FT {ECO:0000303|PubMed:15047893}. FT /FTId=VSP_022229. FT CONFLICT 2 2 L -> V (in Ref. 1; AAM94622). FT {ECO:0000305}. SQ SEQUENCE 743 AA; 82258 MW; B952325D7102ECCC CRC64; MLKQFTHYCE MQAELIPEGP NGEGRLSNQN SNPNLLSSAS ISITQFPAKK PTRQWAAWTH QEEESFFTAL RQVGKNFEKI TSRVQSKNKD QVRHYYYRLV RRMNKLLGPD LSLDAKNPKD TNAAMLRWWS LLEKYSCKAS KLHLKPRRFK LFIEALEHQL LKDRRKSIRK RTCQGENLSS ASLGNISSHS RERGLDNRPF KLILSDGQNV KKLGPGRAST KHGESLSVNL GDEKEDTAFG RGGRQRRKQG YRKWEKAAID GVSLVADAAE HLERTSIDKD MDDQTDLGPT RYLTGKSPLS LCSAGDVPLS DANMQFSAKL KLQLFPIDEC TRRSLEMDKH NPHLELTLSN RKKISSVLEH LNRKWGSSSC ATGELLLFPY NARKETVTCH QRWTHDSFLS AAEVHSMVGS PSVFRLRYGW FVHDASGSII SQVPTSDPCP SLEDDMNVDR LNEVNMLLTE SGPLSVHSTA EQTTSVEPSQ GLVCASGVHD RPARSRDDYE PASTSITPLE HLSGGNAQSP GEWADSLTNI SIGDLLSEVP DDIDSDGVDP PATEGSHYLL RDVPFTSDSF DAAIAAHILR HQNKPSAQLP LTSGSSSLWD DEETRDAFSF QKNRFANSTE LASVASPKGV GRVNGEPSQL VEASSGDEGS YNPHDDGDPM EEGPADPHTM DSPGKTPCGL ADVYWPDSLG PLDLDIRSSK YTDDLILSES LGGLSRLIAT SLDAFQNCSL FGFDNKKDKS NMV //