ID   SWI5_MOUSE              Reviewed;          89 AA.
AC   Q8K3D3; A2AN41;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   17-JUN-2020, entry version 113.
DE   RecName: Full=DNA repair protein SWI5 homolog;
DE   AltName: Full=Protein SAE3 homolog;
GN   Name=Swi5; Synonyms=Sae3;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, IDENTIFICATION IN THE
RP   SWI5-SFR1 COMPLEX, SUBCELLULAR LOCATION, AND INTERACTION WITH RAD51.
RX   PubMed=20976249; DOI=10.1371/journal.pgen.1001160;
RA   Akamatsu Y., Jasin M.;
RT   "Role for the mammalian Swi5-Sfr1 complex in DNA strand break repair
RT   through homologous recombination.";
RL   PLoS Genet. 6:E1001160-E1001160(2010).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   STRAIN=C57BL/6J; TISSUE=Hippocampus;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   STRAIN=Czech II; TISSUE=Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26 (ISOFORM 2), AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Kidney, Lung, Pancreas, Spleen, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Component of the SWI5-SFR1 complex, a complex required for
CC       double-strand break repair via homologous recombination.
CC       {ECO:0000269|PubMed:20976249}.
CC   -!- SUBUNIT: Component of the SWI5-SFR1 complex. Interacts with RAD51.
CC       {ECO:0000269|PubMed:20976249}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20976249}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8K3D3-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8K3D3-2; Sequence=VSP_040899;
CC   -!- SIMILARITY: Belongs to the SWI5/SAE3 family. {ECO:0000305}.
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DR   EMBL; AB597964; BAJ25750.1; -; mRNA.
DR   EMBL; AK013517; BAC25409.1; -; mRNA.
DR   EMBL; AK166608; BAE38890.1; -; mRNA.
DR   EMBL; AL808027; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH466542; EDL08533.1; -; Genomic_DNA.
DR   EMBL; BC021748; AAH21748.1; -; mRNA.
DR   CCDS; CCDS50566.1; -. [Q8K3D3-1]
DR   CCDS; CCDS71026.1; -. [Q8K3D3-2]
DR   RefSeq; NP_001277481.1; NM_001290552.1. [Q8K3D3-2]
DR   RefSeq; NP_780399.1; NM_175190.5. [Q8K3D3-1]
DR   SMR; Q8K3D3; -.
DR   BioGRID; 215652; 1.
DR   IntAct; Q8K3D3; 1.
DR   MINT; Q8K3D3; -.
DR   STRING; 10090.ENSMUSP00000057512; -.
DR   iPTMnet; Q8K3D3; -.
DR   PhosphoSitePlus; Q8K3D3; -.
DR   jPOST; Q8K3D3; -.
DR   PaxDb; Q8K3D3; -.
DR   PeptideAtlas; Q8K3D3; -.
DR   PRIDE; Q8K3D3; -.
DR   Antibodypedia; 58850; 37 antibodies.
DR   DNASU; 72931; -.
DR   Ensembl; ENSMUST00000113395; ENSMUSP00000109022; ENSMUSG00000044627. [Q8K3D3-1]
DR   Ensembl; ENSMUST00000113400; ENSMUSP00000109027; ENSMUSG00000044627. [Q8K3D3-2]
DR   Ensembl; ENSMUST00000183946; ENSMUSP00000139299; ENSMUSG00000044627. [Q8K3D3-1]
DR   GeneID; 72931; -.
DR   KEGG; mmu:72931; -.
DR   UCSC; uc008jet.3; mouse. [Q8K3D3-1]
DR   UCSC; uc012bts.2; mouse. [Q8K3D3-2]
DR   CTD; 375757; -.
DR   MGI; MGI:1920181; Swi5.
DR   eggNOG; ENOG410J117; Eukaryota.
DR   eggNOG; ENOG410XYJT; LUCA.
DR   GeneTree; ENSGT00390000009349; -.
DR   HOGENOM; CLU_106110_1_1_1; -.
DR   InParanoid; Q8K3D3; -.
DR   OMA; ALMENLC; -.
DR   OrthoDB; 1553901at2759; -.
DR   PhylomeDB; Q8K3D3; -.
DR   TreeFam; TF336078; -.
DR   BioGRID-ORCS; 72931; 2 hits in 13 CRISPR screens.
DR   ChiTaRS; Swi5; mouse.
DR   PRO; PR:Q8K3D3; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   RNAct; Q8K3D3; protein.
DR   Bgee; ENSMUSG00000044627; Expressed in ear vesicle and 287 other tissues.
DR   ExpressionAtlas; Q8K3D3; baseline and differential.
DR   Genevisible; Q8K3D3; MM.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0032798; C:Swi5-Sfr1 complex; IDA:UniProtKB.
DR   GO; GO:0071479; P:cellular response to ionizing radiation; ISS:UniProtKB.
DR   GO; GO:0000730; P:DNA recombinase assembly; IBA:GO_Central.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; IMP:UniProtKB.
DR   InterPro; IPR010760; DNA-repair_Swi5.
DR   PANTHER; PTHR28529; PTHR28529; 1.
DR   Pfam; PF07061; Swi5; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Coiled coil; DNA damage; DNA repair; Nucleus;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..89
FT                   /note="DNA repair protein SWI5 homolog"
FT                   /id="PRO_0000324585"
FT   COILED          10..38
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         1
FT                   /note="M -> MGSRGGTALTWGESEFSRLYHGGYRSPQRPFPM (in isoform
FT                   2)"
FT                   /evidence="ECO:0000303|PubMed:20976249"
FT                   /id="VSP_040899"
FT   MOD_RES         Q8K3D3-2:26
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000244|PubMed:21183079"
SQ   SEQUENCE   89 AA;  10261 MW;  AA0FA2E05F9DF60A CRC64;
     MIDENNDVSE EALSSDIKKL KEKHDMLDKE ISQLIAEGYR VIELEKHISL LHEYNDIKDV
     SQMLLGKLAV TRGVTTKELY PDFDLNLND
//