ID NAGA_MOUSE Reviewed; 409 AA. AC Q8JZV7; Q8BK10; DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2002, sequence version 1. DT 16-NOV-2011, entry version 75. DE RecName: Full=Putative N-acetylglucosamine-6-phosphate deacetylase; DE EC=3.5.1.25; DE AltName: Full=Amidohydrolase domain-containing protein 2; DE AltName: Full=GlcNAc 6-P deacetylase; GN Name=Amdhd2; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6J; TISSUE=Amnion; RX PubMed=16141072; DOI=10.1126/science.1112014; RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E., RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., RA Hayashizaki Y.; RT "The transcriptional landscape of the mammalian genome."; RL Science 309:1559-1563(2005). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=FVB/N; TISSUE=Liver; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- CATALYTIC ACTIVITY: N-acetyl-D-glucosamine 6-phosphate + H(2)O = CC D-glucosamine 6-phosphate + acetate. CC -!- SIMILARITY: Belongs to the nagA family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK077584; BAC36877.1; -; mRNA. DR EMBL; AK090009; BAC41042.1; -; mRNA. DR EMBL; AK159860; BAE35434.1; -; mRNA. DR EMBL; AK168432; BAE40339.1; -; mRNA. DR EMBL; BC037005; AAH37005.1; -; mRNA. DR IPI; IPI00323465; -. DR RefSeq; NP_766523.2; NM_172935.4. DR UniGene; Mm.87319; -. DR HSSP; O34450; 1UN7. DR ProteinModelPortal; Q8JZV7; -. DR SMR; Q8JZV7; 12-404. DR STRING; Q8JZV7; -. DR MEROPS; M38.979; -. DR REPRODUCTION-2DPAGE; Q8JZV7; -. DR PRIDE; Q8JZV7; -. DR Ensembl; ENSMUST00000040735; ENSMUSP00000036141; ENSMUSG00000036820. DR GeneID; 245847; -. DR KEGG; mmu:245847; -. DR NMPDR; fig|10090.3.peg.2296; -. DR UCSC; uc008aum.1; mouse. DR CTD; 51005; -. DR MGI; MGI:2443978; Amdhd2. DR eggNOG; roNOG07552; -. DR GeneTree; ENSGT00390000012605; -. DR HOGENOM; HBG464950; -. DR HOVERGEN; HBG108170; -. DR InParanoid; Q8JZV7; -. DR OMA; DGVHTHP; -. DR OrthoDB; EOG45HRXK; -. DR PhylomeDB; Q8JZV7; -. DR NextBio; 386954; -. DR ArrayExpress; Q8JZV7; -. DR Bgee; Q8JZV7; -. DR CleanEx; MM_AMDHD2; -. DR Genevestigator; Q8JZV7; -. DR GO; GO:0008448; F:N-acetylglucosamine-6-phosphate deacetylase activity; IEA:EC. DR GO; GO:0006044; P:N-acetylglucosamine metabolic process; IEA:InterPro. DR InterPro; IPR006680; Amidohydro_1. DR InterPro; IPR003764; GlcNAc_6-P_deAcase. DR InterPro; IPR011059; Metal-dep_hydrolase_composite. DR KO; K01443; -. DR Pfam; PF01979; Amidohydro_1; 1. DR SUPFAM; SSF51338; Metalo_hydrolase; 1. DR TIGRFAMs; TIGR00221; NagA; 1. PE 2: Evidence at transcript level; KW Carbohydrate metabolism; Complete proteome; Hydrolase; KW Reference proteome. FT CHAIN 1 409 Putative N-acetylglucosamine-6-phosphate FT deacetylase. FT /FTId=PRO_0000315777. FT CONFLICT 354 354 L -> M (in Ref. 1; BAC36877). SQ SEQUENCE 409 AA; 43501 MW; 914930464779CAC7 CRC64; MRSGQCAAGA PVLQFTNCRI LRGGTLLRED LWVRGGRILD PEKLFFEERR VADEQRDCGG RILAPGFIDV QINGGFGVDF SKATEDVGSG VALVARRLLS HGVTSFCPTL VTSPPEVYHK VLPQIPVKSG GPHGAGVLGV HLEGPFISRE KRGAHPEAYL RSFEANAFHD VLATYGPLDN VCIVTLAPEL DRSHEVIQAL TAQGIRVSLG HSVADLRAAE VAVQSGATFI THLFNAMLPF HHRDPGIVGL LTSDQLPPGH CIFYGMIADG IHTNPAALRI AHRAHPQGLV LVTDAVPALG LGNGRHTLGQ QEVEVDGLIA YIAGTKTLGG SIAPMDVCVR HFLQATGCSV ESALEAASLH PAQMLGLEKT KGSLDFGADA DFVVLDDTLH VQATYISGEL VWQAEEAGP //