ID Q8IZE1_HUMAN Unreviewed; 44 AA. AC Q8IZE1; DT 01-MAR-2003, integrated into UniProtKB/TrEMBL. DT 01-MAR-2003, sequence version 1. DT 29-MAY-2024, entry version 77. DE SubName: Full=Truncated tyrosine hydroxylase {ECO:0000313|EMBL:AAN39539.1}; DE Flags: Fragment; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:AAN39539.1}; RN [1] {ECO:0000313|EMBL:AAN39539.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Neuroblastoma {ECO:0000313|EMBL:AAN39539.1}; RX PubMed=12493595; DOI=10.1016/S0304-3940(02)01220-X; RA Parareda A., Villaescusa J.C., Sanchez de Toledo J., Gallego S.; RT "New splicing variants for human Tyrosine Hydroxylase gene with possible RT implications for the detection of minimal residual disease in patients with RT neuroblastoma."; RL Neurosci. Lett. 336:29-32(2003). CC -!- COFACTOR: CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033; CC Evidence={ECO:0000256|ARBA:ARBA00001954}; CC -!- SIMILARITY: Belongs to the biopterin-dependent aromatic amino acid CC hydroxylase family. {ECO:0000256|ARBA:ARBA00009712}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY144495; AAN39539.1; -; mRNA. DR AlphaFoldDB; Q8IZE1; -. DR PeptideAtlas; Q8IZE1; -. DR OMA; VRYNPHT; -. DR GO; GO:0030424; C:axon; IEA:TreeGrafter. DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter. DR GO; GO:0043204; C:perikaryon; IEA:TreeGrafter. DR GO; GO:0005506; F:iron ion binding; IEA:InterPro. DR GO; GO:0004511; F:tyrosine 3-monooxygenase activity; IEA:TreeGrafter. DR GO; GO:0006585; P:dopamine biosynthetic process from tyrosine; IEA:TreeGrafter. DR GO; GO:0007507; P:heart development; IEA:TreeGrafter. DR GO; GO:0045471; P:response to ethanol; IEA:TreeGrafter. DR GO; GO:0001666; P:response to hypoxia; IEA:TreeGrafter. DR Gene3D; 1.10.800.10; Aromatic amino acid hydroxylase; 1. DR InterPro; IPR001273; ArAA_hydroxylase. DR InterPro; IPR036951; ArAA_hydroxylase_sf. DR InterPro; IPR036329; Aro-AA_hydroxylase_C_sf. DR InterPro; IPR019774; Aromatic-AA_hydroxylase_C. DR PANTHER; PTHR11473; AROMATIC AMINO ACID HYDROXYLASE; 1. DR PANTHER; PTHR11473:SF18; TYROSINE 3-MONOOXYGENASE; 1. DR Pfam; PF00351; Biopterin_H; 1. DR SUPFAM; SSF56534; Aromatic aminoacid monoxygenases, catalytic and oligomerization domains; 1. DR PROSITE; PS51410; BH4_AAA_HYDROXYL_2; 1. PE 2: Evidence at transcript level; KW Iron {ECO:0000256|ARBA:ARBA00023004}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Monooxygenase {ECO:0000256|ARBA:ARBA00023033}; KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}. FT DOMAIN 1..44 FT /note="Biopterin-dependent aromatic amino acid hydroxylase FT family profile" FT /evidence="ECO:0000259|PROSITE:PS51410" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:AAN39539.1" SQ SEQUENCE 44 AA; 5203 MW; 6E4BCB99D0827690 CRC64; DLDHPGFSDQ VYRQRRKLIA EIAFQYRHGD PIPRVEYTAE EIAT //