ID   DND1_HUMAN              Reviewed;         353 AA.
AC   Q8IYX4;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 151.
DE   RecName: Full=Dead end protein homolog 1;
DE   AltName: Full=RNA-binding motif, single-stranded-interacting protein 4;
GN   Name=DND1; Synonyms=RBMS4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=12932328; DOI=10.1016/s0960-9822(03)00537-2;
RA   Weidinger G., Stebler J., Slanchev K., Dumstrei K., Wise C.,
RA   Lovell-Badge R., Thisse C., Thisse B., Raz E.;
RT   "Dead end, a novel vertebrate germ plasm component, is required for
RT   zebrafish primordial germ cell migration and survival.";
RL   Curr. Biol. 13:1429-1434(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   FUNCTION, RNA-BINDING, AND SUBCELLULAR LOCATION.
RX   PubMed=18155131; DOI=10.1016/j.cell.2007.11.034;
RA   Kedde M., Strasser M.J., Boldajipour B., Oude Vrielink J.A., Slanchev K.,
RA   le Sage C., Nagel R., Voorhoeve P.M., van Duijse J., Oerom U.A., Lund A.H.,
RA   Perrakis A., Raz E., Agami R.;
RT   "RNA-binding protein Dnd1 inhibits microRNA access to target mRNA.";
RL   Cell 131:1273-1286(2007).
CC   -!- FUNCTION: RNA-binding factor that positively regulates gene expression
CC       by prohibiting miRNA-mediated gene suppression. Relieves miRNA
CC       repression in germline cells (By similarity). Prohibits the function of
CC       several miRNAs by blocking the accessibility of target mRNAs. Sequence-
CC       specific RNA-binding factor that binds specifically to U-rich regions
CC       (URRs) in the 3' untranslated region (3'-UTR) of several mRNAs. Does
CC       not bind to miRNAs. May play a role during primordial germ cell (PGC)
CC       survival (By similarity). However, does not seem to be essential for
CC       PGC migration (By similarity). {ECO:0000250,
CC       ECO:0000269|PubMed:18155131}.
CC   -!- SUBUNIT: Interacts with APOBEC3. {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q8IYX4; Q6ZRY4: RBPMS2; NbExp=3; IntAct=EBI-12071340, EBI-11987469;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18155131}. Cytoplasm
CC       {ECO:0000269|PubMed:18155131}. Note=Perinuclear germ granules, also
CC       called germ plasm or chromatoid body. Colocalizes in perinuclear sites
CC       with APOBEC3 (By similarity). {ECO:0000250}.
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DR   EMBL; AY321065; AAQ63635.1; -; mRNA.
DR   EMBL; BC033496; AAH33496.1; -; mRNA.
DR   CCDS; CCDS4236.1; -.
DR   RefSeq; NP_919225.1; NM_194249.2.
DR   PDB; 6LE1; X-ray; 2.30 A; A=139-217.
DR   PDBsum; 6LE1; -.
DR   AlphaFoldDB; Q8IYX4; -.
DR   SMR; Q8IYX4; -.
DR   BioGRID; 131887; 19.
DR   IntAct; Q8IYX4; 8.
DR   STRING; 9606.ENSP00000445366; -.
DR   iPTMnet; Q8IYX4; -.
DR   PhosphoSitePlus; Q8IYX4; -.
DR   BioMuta; DND1; -.
DR   DMDM; 60389799; -.
DR   EPD; Q8IYX4; -.
DR   MassIVE; Q8IYX4; -.
DR   PaxDb; Q8IYX4; -.
DR   PeptideAtlas; Q8IYX4; -.
DR   PRIDE; Q8IYX4; -.
DR   ProteomicsDB; 71258; -.
DR   Antibodypedia; 49888; 228 antibodies from 23 providers.
DR   DNASU; 373863; -.
DR   Ensembl; ENST00000542735.2; ENSP00000445366.1; ENSG00000256453.2.
DR   GeneID; 373863; -.
DR   KEGG; hsa:373863; -.
DR   MANE-Select; ENST00000542735.2; ENSP00000445366.1; NM_194249.3; NP_919225.1.
DR   UCSC; uc003lgt.4; human.
DR   CTD; 373863; -.
DR   DisGeNET; 373863; -.
DR   GeneCards; DND1; -.
DR   HGNC; HGNC:23799; DND1.
DR   HPA; ENSG00000256453; Tissue enhanced (testis).
DR   MIM; 609385; gene.
DR   neXtProt; NX_Q8IYX4; -.
DR   OpenTargets; ENSG00000256453; -.
DR   PharmGKB; PA134931157; -.
DR   VEuPathDB; HostDB:ENSG00000256453; -.
DR   eggNOG; KOG0117; Eukaryota.
DR   GeneTree; ENSGT00940000159225; -.
DR   HOGENOM; CLU_022960_0_0_1; -.
DR   InParanoid; Q8IYX4; -.
DR   OMA; QLWCERV; -.
DR   OrthoDB; 1384330at2759; -.
DR   PhylomeDB; Q8IYX4; -.
DR   TreeFam; TF314932; -.
DR   PathwayCommons; Q8IYX4; -.
DR   SignaLink; Q8IYX4; -.
DR   BioGRID-ORCS; 373863; 22 hits in 1062 CRISPR screens.
DR   GenomeRNAi; 373863; -.
DR   Pharos; Q8IYX4; Tbio.
DR   PRO; PR:Q8IYX4; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   RNAct; Q8IYX4; protein.
DR   Bgee; ENSG00000256453; Expressed in right testis and 82 other tissues.
DR   Genevisible; Q8IYX4; HS.
DR   GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; IDA:HPA.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0003730; F:mRNA 3'-UTR binding; IDA:UniProtKB.
DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0061158; P:3'-UTR-mediated mRNA destabilization; IDA:CACAO.
DR   GO; GO:0007281; P:germ cell development; IEA:Ensembl.
DR   GO; GO:0048255; P:mRNA stabilization; IBA:GO_Central.
DR   GO; GO:0060965; P:negative regulation of miRNA-mediated gene silencing; IDA:UniProtKB.
DR   GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR   CDD; cd20313; DSRM_DND1; 1.
DR   CDD; cd12487; RRM1_DND1; 1.
DR   Gene3D; 3.30.70.330; -; 2.
DR   InterPro; IPR044448; DND1_DSRM.
DR   InterPro; IPR034414; DND1_RRM1.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF00076; RRM_1; 1.
DR   SMART; SM00360; RRM; 2.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50102; RRM; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cytoplasm; Developmental protein; Nucleus;
KW   Reference proteome; Repeat; RNA-binding.
FT   CHAIN           1..353
FT                   /note="Dead end protein homolog 1"
FT                   /id="PRO_0000081568"
FT   DOMAIN          58..136
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          140..213
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   STRAND          139..145
FT                   /evidence="ECO:0007829|PDB:6LE1"
FT   HELIX           151..158
FT                   /evidence="ECO:0007829|PDB:6LE1"
FT   HELIX           159..161
FT                   /evidence="ECO:0007829|PDB:6LE1"
FT   STRAND          165..172
FT                   /evidence="ECO:0007829|PDB:6LE1"
FT   STRAND          174..177
FT                   /evidence="ECO:0007829|PDB:6LE1"
FT   STRAND          180..188
FT                   /evidence="ECO:0007829|PDB:6LE1"
FT   HELIX           189..205
FT                   /evidence="ECO:0007829|PDB:6LE1"
SQ   SEQUENCE   353 AA;  38687 MW;  15014AA66BFD4F0F CRC64;
     MQSKRDCELW CERVNPENKA ALEAWVRETG IRLVQVNGQR KYGGPPPGWV GSPPPAGSEV
     FIGRLPQDVY EHQLIPLFQR VGRLYEFRLM MTFSGLNRGF AYARYSSRRG AQAAIATLHN
     HPLRPSCPLL VCRSTEKCEL SVDGLPPNLT RSALLLALQP LGPGLQEARL LPSPGPAPGQ
     IALLKFSSHR AAAMAKKALV EGQSHLCGEQ VAVEWLKPDL KQRLRQQLVG PFLRSPQPEG
     SQLALARDKL GFQGARATLQ LLCQRMKLGS PVFLTKCLGI GPAGWHRFWY QVVIPGHPVP
     FSGLIWVVLT LDGRDGHEVA KDAVSVRLLQ ALSESGANLL WSAGAEAGTM VKQ
//