ID ZN100_HUMAN Reviewed; 542 AA. AC Q8IYN0; Q7M4M0; DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot. DT 18-MAY-2010, sequence version 2. DT 17-JUN-2020, entry version 156. DE RecName: Full=Zinc finger protein 100; GN Name=ZNF100; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15057824; DOI=10.1038/nature02399; RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A., RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., RA Rubin E.M., Lucas S.M.; RT "The DNA sequence and biology of human chromosome 19."; RL Nature 428:529-535(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ILE-389. RC TISSUE=Testis; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 381-437, AND VARIANT ILE-389. RX PubMed=1740334; DOI=10.1016/0888-7543(92)90372-y; RA Hoovers J.M.N., Mannens M., John R., Bliek J., van Heyningen V., RA Porteous D.J., Leschot N.J., Westerveld A., Little P.F.R.; RT "High-resolution localization of 69 potential human zinc finger protein RT genes: a number are clustered."; RL Genomics 12:254-263(1992). CC -!- FUNCTION: May be involved in transcriptional regulation. CC -!- INTERACTION: CC Q8IYN0; P59991: KRTAP12-2; NbExp=3; IntAct=EBI-2849363, EBI-10176379; CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein CC family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC092364; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC035579; AAH35579.1; -; mRNA. DR CCDS; CCDS42538.1; -. DR PIR; E42075; E42075. DR RefSeq; NP_775802.2; NM_173531.3. DR SMR; Q8IYN0; -. DR BioGRID; 127858; 6. DR IntAct; Q8IYN0; 6. DR STRING; 9606.ENSP00000351042; -. DR iPTMnet; Q8IYN0; -. DR PhosphoSitePlus; Q8IYN0; -. DR BioMuta; ZNF100; -. DR DMDM; 296453037; -. DR EPD; Q8IYN0; -. DR jPOST; Q8IYN0; -. DR MassIVE; Q8IYN0; -. DR MaxQB; Q8IYN0; -. DR PaxDb; Q8IYN0; -. DR PeptideAtlas; Q8IYN0; -. DR PRIDE; Q8IYN0; -. DR ProteomicsDB; 71207; -. DR Antibodypedia; 28703; 34 antibodies. DR Ensembl; ENST00000358296; ENSP00000351042; ENSG00000197020. DR Ensembl; ENST00000614218; ENSP00000483779; ENSG00000274746. DR GeneID; 163227; -. DR KEGG; hsa:163227; -. DR UCSC; uc002nqi.4; human. DR CTD; 163227; -. DR EuPathDB; HostDB:ENSG00000197020.10; -. DR GeneCards; ZNF100; -. DR HGNC; HGNC:12880; ZNF100. DR HPA; ENSG00000197020; Low tissue specificity. DR MIM; 603982; gene. DR neXtProt; NX_Q8IYN0; -. DR OpenTargets; ENSG00000197020; -. DR PharmGKB; PA37469; -. DR eggNOG; KOG1721; Eukaryota. DR eggNOG; COG5048; LUCA. DR GeneTree; ENSGT00990000203478; -. DR InParanoid; Q8IYN0; -. DR KO; K09228; -. DR OrthoDB; 1318335at2759; -. DR PhylomeDB; Q8IYN0; -. DR TreeFam; TF342117; -. DR Reactome; R-HSA-212436; Generic Transcription Pathway. DR BioGRID-ORCS; 163227; 6 hits in 809 CRISPR screens. DR ChiTaRS; ZNF100; human. DR GenomeRNAi; 163227; -. DR Pharos; Q8IYN0; Tdark. DR PRO; PR:Q8IYN0; -. DR Proteomes; UP000005640; Chromosome 19. DR RNAct; Q8IYN0; protein. DR Bgee; ENSG00000197020; Expressed in kidney and 124 other tissues. DR ExpressionAtlas; Q8IYN0; baseline and differential. DR Genevisible; Q8IYN0; HS. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro. DR CDD; cd07765; KRAB_A-box; 1. DR InterPro; IPR001909; KRAB. DR InterPro; IPR036051; KRAB_dom_sf. DR InterPro; IPR036236; Znf_C2H2_sf. DR InterPro; IPR013087; Znf_C2H2_type. DR Pfam; PF01352; KRAB; 1. DR Pfam; PF00096; zf-C2H2; 10. DR SMART; SM00349; KRAB; 1. DR SMART; SM00355; ZnF_C2H2; 11. DR SUPFAM; SSF109640; SSF109640; 1. DR SUPFAM; SSF57667; SSF57667; 6. DR PROSITE; PS50805; KRAB; 1. DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11. DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12. PE 1: Evidence at protein level; KW DNA-binding; Metal-binding; Nucleus; Polymorphism; Reference proteome; KW Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. FT CHAIN 1..542 FT /note="Zinc finger protein 100" FT /id="PRO_0000047405" FT DOMAIN 35..107 FT /note="KRAB" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119" FT ZN_FING 177..199 FT /note="C2H2-type 1; degenerate" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 205..227 FT /note="C2H2-type 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 233..255 FT /note="C2H2-type 3" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 261..283 FT /note="C2H2-type 4" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 289..311 FT /note="C2H2-type 5" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 317..339 FT /note="C2H2-type 6" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 345..367 FT /note="C2H2-type 7" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 373..395 FT /note="C2H2-type 8" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 401..423 FT /note="C2H2-type 9" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 429..451 FT /note="C2H2-type 10" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 457..479 FT /note="C2H2-type 11" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT ZN_FING 485..507 FT /note="C2H2-type 12" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042" FT VARIANT 8 FT /note="M -> V (in dbSNP:rs12974842)" FT /id="VAR_057395" FT VARIANT 389 FT /note="T -> I (in dbSNP:rs7246400)" FT /evidence="ECO:0000269|PubMed:15489334, FT ECO:0000269|PubMed:1740334" FT /id="VAR_060422" FT CONFLICT 411..412 FT /note="NW -> WN (in Ref. 3; no nucleotide entry)" FT /evidence="ECO:0000305" SQ SEQUENCE 542 AA; 62745 MW; 9755C6215FC44C87 CRC64; MDDPRYGMCP LKGASGCPGA ERSLLVQSYF EKGPLTFRDV AIEFSLEEWQ CLDSAQQGLY RKVMLENYRN LVFLAGIALT KPDLITCLEQ GKEPWNIKRH EMVAKPPVIC SHFPQDLWAE QDIKDSFQEA ILKKYGKYGH DNLQLQKGCK SVDECKVHKE HDNKLNQCLI TTQSNIFQCD PSAKVFHTFS NSNRHKIRHT RKKPFKCKKC EKSFCMLLHL TQHKRFHITE NSYQCKDCGK AFNWFSTLTT HRRIHTGEKP YKCEECGKAF NRSSHLTTHK IIHTGEKPYR CEECGKAFNR SSHLTTHKRI HTGVKPYKCT ECGKAFNRSS HLTTHRIIHT GEKPYKCEEC GKAFNQSSTL TTHKITHAGE KPYKCEECGK AFYRFSYLTK HKTSHTGEKF YKCEECGKGF NWSSALTKHK RIHTGEKPYK CEECGKAFNE SSNLTTHKMI HTGEKPYKCD ECGKAFNRSS QLTAHKMIHT GEKPYKCEEC GKAFNRSSTL TKHKITHTGE KSYKWEECGK DFNQSLSLIK QNNSYWRETL QM //