ID   ZN100_HUMAN             Reviewed;         542 AA.
AC   Q8IYN0; Q7M4M0;
DT   23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 2.
DT   29-OCT-2014, entry version 109.
DE   RecName: Full=Zinc finger protein 100;
GN   Name=ZNF100;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ILE-389.
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 381-437, AND VARIANT ILE-389.
RX   PubMed=1740334; DOI=10.1016/0888-7543(92)90372-Y;
RA   Hoovers J.M.N., Mannens M., John R., Bliek J., van Heyningen V.,
RA   Porteous D.J., Leschot N.J., Westerveld A., Little P.F.R.;
RT   "High-resolution localization of 69 potential human zinc finger
RT   protein genes: a number are clustered.";
RL   Genomics 12:254-263(1992).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
CC   -!- SIMILARITY: Contains 12 C2H2-type zinc fingers.
CC       {ECO:0000255|PROSITE-ProRule:PRU00042}.
CC   -!- SIMILARITY: Contains 1 KRAB domain. {ECO:0000255|PROSITE-
CC       ProRule:PRU00119}.
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DR   EMBL; AC092364; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC035579; AAH35579.1; -; mRNA.
DR   CCDS; CCDS42538.1; -.
DR   PIR; E42075; E42075.
DR   RefSeq; NP_775802.2; NM_173531.3.
DR   UniGene; Hs.365142; -.
DR   ProteinModelPortal; Q8IYN0; -.
DR   SMR; Q8IYN0; 177-537.
DR   BioGrid; 127858; 1.
DR   IntAct; Q8IYN0; 1.
DR   PhosphoSite; Q8IYN0; -.
DR   DMDM; 296453037; -.
DR   MaxQB; Q8IYN0; -.
DR   PaxDb; Q8IYN0; -.
DR   PRIDE; Q8IYN0; -.
DR   Ensembl; ENST00000358296; ENSP00000351042; ENSG00000197020.
DR   Ensembl; ENST00000614218; ENSP00000483779; ENSG00000274746.
DR   GeneID; 163227; -.
DR   KEGG; hsa:163227; -.
DR   UCSC; uc002nqi.3; human.
DR   CTD; 163227; -.
DR   GeneCards; GC19M021906; -.
DR   HGNC; HGNC:12880; ZNF100.
DR   HPA; HPA059135; -.
DR   MIM; 603982; gene.
DR   neXtProt; NX_Q8IYN0; -.
DR   PharmGKB; PA37469; -.
DR   eggNOG; COG5048; -.
DR   GeneTree; ENSGT00550000074383; -.
DR   HOGENOM; HOG000234617; -.
DR   HOVERGEN; HBG018163; -.
DR   InParanoid; Q8IYN0; -.
DR   KO; K09228; -.
DR   OMA; CKVHKEH; -.
DR   PhylomeDB; Q8IYN0; -.
DR   TreeFam; TF342117; -.
DR   Reactome; REACT_12627; Generic Transcription Pathway.
DR   ChiTaRS; ZNF100; human.
DR   GenomeRNAi; 163227; -.
DR   NextBio; 88332; -.
DR   PRO; PR:Q8IYN0; -.
DR   Bgee; Q8IYN0; -.
DR   CleanEx; HS_ZNF100; -.
DR   ExpressionAtlas; Q8IYN0; baseline and differential.
DR   Genevestigator; Q8IYN0; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.160.60; -; 12.
DR   InterPro; IPR001909; Krueppel-associated_box.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Pfam; PF01352; KRAB; 1.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 11.
DR   SUPFAM; SSF109640; SSF109640; 1.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE   2: Evidence at transcript level;
KW   Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism;
KW   Reference proteome; Repeat; Transcription; Transcription regulation;
KW   Zinc; Zinc-finger.
FT   CHAIN         1    542       Zinc finger protein 100.
FT                                /FTId=PRO_0000047405.
FT   DOMAIN       35    107       KRAB. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00119}.
FT   ZN_FING     177    199       C2H2-type 1; degenerate.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00042}.
FT   ZN_FING     205    227       C2H2-type 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     233    255       C2H2-type 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     261    283       C2H2-type 4. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     289    311       C2H2-type 5. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     317    339       C2H2-type 6. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     345    367       C2H2-type 7. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     373    395       C2H2-type 8. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     401    423       C2H2-type 9. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     429    451       C2H2-type 10. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     457    479       C2H2-type 11. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     485    507       C2H2-type 12. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   VARIANT       8      8       M -> V (in dbSNP:rs12974842).
FT                                /FTId=VAR_057395.
FT   VARIANT     389    389       T -> I (in dbSNP:rs7246400).
FT                                {ECO:0000269|PubMed:15489334,
FT                                ECO:0000269|PubMed:1740334}.
FT                                /FTId=VAR_060422.
FT   CONFLICT    411    412       NW -> WN (in Ref. 3; no nucleotide
FT                                entry). {ECO:0000305}.
SQ   SEQUENCE   542 AA;  62745 MW;  9755C6215FC44C87 CRC64;
     MDDPRYGMCP LKGASGCPGA ERSLLVQSYF EKGPLTFRDV AIEFSLEEWQ CLDSAQQGLY
     RKVMLENYRN LVFLAGIALT KPDLITCLEQ GKEPWNIKRH EMVAKPPVIC SHFPQDLWAE
     QDIKDSFQEA ILKKYGKYGH DNLQLQKGCK SVDECKVHKE HDNKLNQCLI TTQSNIFQCD
     PSAKVFHTFS NSNRHKIRHT RKKPFKCKKC EKSFCMLLHL TQHKRFHITE NSYQCKDCGK
     AFNWFSTLTT HRRIHTGEKP YKCEECGKAF NRSSHLTTHK IIHTGEKPYR CEECGKAFNR
     SSHLTTHKRI HTGVKPYKCT ECGKAFNRSS HLTTHRIIHT GEKPYKCEEC GKAFNQSSTL
     TTHKITHAGE KPYKCEECGK AFYRFSYLTK HKTSHTGEKF YKCEECGKGF NWSSALTKHK
     RIHTGEKPYK CEECGKAFNE SSNLTTHKMI HTGEKPYKCD ECGKAFNRSS QLTAHKMIHT
     GEKPYKCEEC GKAFNRSSTL TKHKITHTGE KSYKWEECGK DFNQSLSLIK QNNSYWRETL
     QM
//