ID   ZN695_HUMAN             Reviewed;         515 AA.
AC   Q8IW36; Q5T0N9; Q5T0P1; Q5T0P3; Q7Z2W8; Q7Z648;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JAN-2010, sequence version 4.
DT   07-OCT-2020, entry version 142.
DE   RecName: Full=Zinc finger protein 695;
DE   AltName: Full=Zinc finger protein SBZF3;
GN   Name=ZNF695;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), AND VARIANTS
RP   LYS-84 AND ALA-87.
RC   TISSUE=Leiomyosarcoma, and Lung carcinoma;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- INTERACTION:
CC       Q8IW36; P50222: MEOX2; NbExp=3; IntAct=EBI-10261951, EBI-748397;
CC       Q8IW36-1; Q96JY6: PDLIM2; NbExp=3; IntAct=EBI-18985109, EBI-9057264;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=4;
CC       Name=4;
CC         IsoId=Q8IW36-4; Sequence=Displayed;
CC       Name=1;
CC         IsoId=Q8IW36-1; Sequence=VSP_038548, VSP_038549;
CC       Name=2;
CC         IsoId=Q8IW36-2; Sequence=VSP_018108, VSP_018109;
CC       Name=3;
CC         IsoId=Q8IW36-3; Sequence=VSP_018106, VSP_018107;
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DR   EMBL; AC113174; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL512637; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC023527; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; BC041082; AAH41082.2; -; mRNA.
DR   EMBL; BC055096; -; NOT_ANNOTATED_CDS; mRNA.
DR   CCDS; CCDS44344.1; -. [Q8IW36-4]
DR   CCDS; CCDS55694.1; -. [Q8IW36-1]
DR   RefSeq; NP_001191150.1; NM_001204221.1. [Q8IW36-1]
DR   SMR; Q8IW36; -.
DR   BioGRID; 121380; 15.
DR   IntAct; Q8IW36; 13.
DR   STRING; 9606.ENSP00000341236; -.
DR   iPTMnet; Q8IW36; -.
DR   PhosphoSitePlus; Q8IW36; -.
DR   BioMuta; ZNF695; -.
DR   DMDM; 284018174; -.
DR   EPD; Q8IW36; -.
DR   jPOST; Q8IW36; -.
DR   MassIVE; Q8IW36; -.
DR   PaxDb; Q8IW36; -.
DR   PeptideAtlas; Q8IW36; -.
DR   PRIDE; Q8IW36; -.
DR   ProteomicsDB; 70800; -. [Q8IW36-4]
DR   ProteomicsDB; 70801; -. [Q8IW36-1]
DR   ProteomicsDB; 70802; -. [Q8IW36-2]
DR   ProteomicsDB; 70803; -. [Q8IW36-3]
DR   Antibodypedia; 11896; 136 antibodies.
DR   DNASU; 57116; -.
DR   Ensembl; ENST00000339986; ENSP00000341236; ENSG00000197472. [Q8IW36-4]
DR   Ensembl; ENST00000366504; ENSP00000355460; ENSG00000197472. [Q8IW36-2]
DR   Ensembl; ENST00000487338; ENSP00000429736; ENSG00000197472. [Q8IW36-1]
DR   GeneID; 57116; -.
DR   KEGG; hsa:57116; -.
DR   UCSC; uc001ibx.4; human. [Q8IW36-4]
DR   CTD; 57116; -.
DR   DisGeNET; 57116; -.
DR   EuPathDB; HostDB:ENSG00000197472.14; -.
DR   GeneCards; ZNF695; -.
DR   HGNC; HGNC:30954; ZNF695.
DR   HPA; ENSG00000197472; Tissue enhanced (lymphoid tissue, testis).
DR   MIM; 616348; gene.
DR   neXtProt; NX_Q8IW36; -.
DR   OpenTargets; ENSG00000197472; -.
DR   PharmGKB; PA142670493; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00940000154251; -.
DR   HOGENOM; CLU_002678_69_5_1; -.
DR   InParanoid; Q8IW36; -.
DR   OMA; FTDYKRI; -.
DR   OrthoDB; 1318335at2759; -.
DR   PhylomeDB; Q8IW36; -.
DR   TreeFam; TF342117; -.
DR   PathwayCommons; Q8IW36; -.
DR   BioGRID-ORCS; 57116; 6 hits in 893 CRISPR screens.
DR   GenomeRNAi; 57116; -.
DR   Pharos; Q8IW36; Tdark.
DR   PRO; PR:Q8IW36; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q8IW36; protein.
DR   Bgee; ENSG00000197472; Expressed in sural nerve and 102 other tissues.
DR   ExpressionAtlas; Q8IW36; baseline and differential.
DR   Genevisible; Q8IW36; HS.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   CDD; cd07765; KRAB_A-box; 1.
DR   InterPro; IPR001909; KRAB.
DR   InterPro; IPR036051; KRAB_dom_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 9.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 12.
DR   SUPFAM; SSF109640; SSF109640; 1.
DR   SUPFAM; SSF57667; SSF57667; 7.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 9.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 13.
PE   1: Evidence at protein level;
KW   Alternative splicing; Metal-binding; Nucleus; Polymorphism;
KW   Reference proteome; Repeat; Zinc; Zinc-finger.
FT   CHAIN           1..515
FT                   /note="Zinc finger protein 695"
FT                   /id="PRO_0000233282"
FT   DOMAIN          4..87
FT                   /note="KRAB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT   ZN_FING         156..178
FT                   /note="C2H2-type 1; atypical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         184..206
FT                   /note="C2H2-type 2; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         212..234
FT                   /note="C2H2-type 3; atypical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         240..262
FT                   /note="C2H2-type 4; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         268..290
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         296..318
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         324..346
FT                   /note="C2H2-type 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         352..374
FT                   /note="C2H2-type 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         380..402
FT                   /note="C2H2-type 9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         408..430
FT                   /note="C2H2-type 10"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         436..458
FT                   /note="C2H2-type 11"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         464..486
FT                   /note="C2H2-type 12"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         492..514
FT                   /note="C2H2-type 13"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   VAR_SEQ         88
FT                   /note="L -> M (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_018106"
FT   VAR_SEQ         89..515
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_018107"
FT   VAR_SEQ         131..172
FT                   /note="VGEWKGQKASYNGLDLCSATTHSKNFQCNKCVKGFSKFANLN -> PCEDVL
FT                   ASPLPSAMILSFLRPPQKQKHVKPTEPVQSSTIELL (in isoform 1)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_038548"
FT   VAR_SEQ         132..133
FT                   /note="GE -> AM (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_018108"
FT   VAR_SEQ         134..515
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_018109"
FT   VAR_SEQ         173..515
FT                   /note="Missing (in isoform 1)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_038549"
FT   VARIANT         84
FT                   /note="R -> K (in dbSNP:rs2642973)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_057446"
FT   VARIANT         87
FT                   /note="V -> A (in dbSNP:rs2642992)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_057447"
FT   VARIANT         110
FT                   /note="M -> I (in dbSNP:rs55762230)"
FT                   /id="VAR_061963"
SQ   SEQUENCE   515 AA;  60149 MW;  B37EA43D0B16E8B5 CRC64;
     MGLLAFRDVA LEFSPEEWEC LDPAQRSLYR DVMLENYRNL ISLGEDSFNM QFLFHSLAMS
     KPELIICLEA RKEPWNVNTE KTARHSVLSS YLTEDILPEQ GLQVSFQKVM LRRYERCCLE
     KLRLRNDWEI VGEWKGQKAS YNGLDLCSAT THSKNFQCNK CVKGFSKFAN LNKCKISHTG
     EKPFKCKECG NVSCMSLIMT QQQRIHIGEN PYQCKKCGKA FNECSCFTDC KRIHVGEKHC
     KCEECNNIFK SCSSLAVVEK NHTEKKTYRC EECGKAFNLC SVLTKHKKIH TGEKPYKCEE
     CGKSFKLFPY LTQHKRIHSR EKPYKCEECG KVFKLLSYLT QHRRIHTGEK TFRCEECGKA
     FNQSSHLTEH RRIHTGEKPY KCEECGKAFT WFSYLIQHKR IHTGQKPYKC EECGKAFTWF
     SYLTQHKRIH TGEKPYKCDE CGKAFNWFSY LTNHKRIHTG EKPYKCEECG KAFGQSSHLS
     KHKTIHTREK PYKCEECGKA FNHSAQLAVH EKTHT
//