ID Q8IRL9_DROME Unreviewed; 1100 AA. AC Q8IRL9; DT 01-MAR-2003, integrated into UniProtKB/TrEMBL. DT 01-MAR-2003, sequence version 1. DT 18-SEP-2019, entry version 137. DE SubName: Full=FI06813p {ECO:0000313|EMBL:ACS78060.1}; GN Name=DNA2 {ECO:0000313|EMBL:AAN09623.1}; GN Synonyms=CG2990-RB {ECO:0000313|EMBL:ACS78060.1}, Dmel\CG2990 GN {ECO:0000313|EMBL:AAN09623.1}; GN ORFNames=CG2990 {ECO:0000313|EMBL:AAN09623.1, GN ECO:0000313|FlyBase:FBgn0030170}, Dmel_CG2990 GN {ECO:0000313|EMBL:AAN09623.1}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAN09623.1, ECO:0000313|Proteomes:UP000000803}; RN [1] {ECO:0000313|EMBL:AAN09623.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., RA Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., RA Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., RA Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., RA Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., RA Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., RA Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., RA Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., RA Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., RA de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., RA Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., RA Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., RA Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., RA Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., RA Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., RA Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., RA Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., RA Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., RA Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., RA Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., RA Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., RA Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., RA Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., RA Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., RA Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., RA Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., RA Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., RA Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., RA Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., RA Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [2] {ECO:0000313|EMBL:AAN09623.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila RT melanogaster euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [3] {ECO:0000313|EMBL:AAN09623.1, ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., RA Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., RA Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a RT systematic review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [4] {ECO:0000313|EMBL:AAN09623.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., RA Ashburner M., Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: RT a genomics perspective."; RL Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002). RN [5] {ECO:0000313|EMBL:AAN09623.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun RT assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [6] {ECO:0000313|EMBL:AAN09623.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [7] {ECO:0000313|EMBL:AAN09623.1} RP NUCLEOTIDE SEQUENCE. RG Berkeley Drosophila Genome Project; RA Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., RA Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., RA Yu C., Rubin G.; RT "Drosophila melanogaster release 4 sequence."; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [8] {ECO:0000313|EMBL:AAN09623.1} RP NUCLEOTIDE SEQUENCE. RA Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., RA Svirskas R., Rubin G.; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|EMBL:AAN09623.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster RT heterochromatin."; RL Science 316:1586-1591(2007). RN [10] {ECO:0000313|EMBL:AAN09623.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). RN [11] {ECO:0000313|EMBL:ACS78060.1} RP NUCLEOTIDE SEQUENCE. RA Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.; RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases. RN [12] {ECO:0000313|EMBL:AAN09623.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=26109357; DOI=.1534/g3.115.018929; RG FlyBase Consortium; RA Matthews B.B., Dos Santos G., Crosby M.A., Emmert D.B., RA St Pierre S.E., Gramates L.S., Zhou P., Schroeder A.J., Falls K., RA Strelets V., Russo S.M., Gelbart W.M.; RT "Gene Model Annotations for Drosophila melanogaster: Impact of High- RT Throughput Data."; RL G3 (Bethesda) 5:1721-1736(2015). RN [13] {ECO:0000313|EMBL:AAN09623.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=26109356; DOI=.1534/g3.115.018937; RG FlyBase Consortium; RA Crosby M.A., Gramates L.S., Dos Santos G., Matthews B.B., RA St Pierre S.E., Zhou P., Schroeder A.J., Falls K., Emmert D.B., RA Russo S.M., Gelbart W.M.; RT "Gene Model Annotations for Drosophila melanogaster: The Rule- RT Benders."; RL G3 (Bethesda) 5:1737-1749(2015). RN [14] {ECO:0000313|EMBL:AAN09623.1} RP NUCLEOTIDE SEQUENCE. RG FlyBase; RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE014298; AAN09623.1; -; Genomic_DNA. DR EMBL; BT088860; ACS78060.1; -; mRNA. DR RefSeq; NP_727386.1; NM_167214.2. DR STRING; 7227.FBpp0071350; -. DR GeneID; 31934; -. DR UCSC; CG2990-RB; d. melanogaster. DR FlyBase; FBgn0030170; CG2990. DR eggNOG; KOG1805; Eukaryota. DR eggNOG; COG1112; LUCA. DR GeneTree; ENSGT00940000165719; -. DR OrthoDB; 633768at2759; -. DR Reactome; R-DME-174437; Removal of the Flap Intermediate from the C-strand. DR Reactome; R-DME-69166; Removal of the Flap Intermediate. DR GenomeRNAi; 31934; -. DR Proteomes; UP000000803; Chromosome X. DR Bgee; FBgn0030170; Expressed in 12 organ(s), highest expression level in secondary oocyte. DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central. DR GO; GO:0000784; C:nuclear chromosome, telomeric region; IBA:GO_Central. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:0017108; F:5'-flap endonuclease activity; IBA:GO_Central. DR GO; GO:0003723; F:RNA binding; IBA:GO_Central. DR GO; GO:0017116; F:single-stranded DNA helicase activity; IEA:InterPro. DR GO; GO:0033567; P:DNA replication, Okazaki fragment processing; IEA:InterPro. DR GO; GO:0071932; P:replication fork reversal; IBA:GO_Central. DR InterPro; IPR026851; Dna2. DR InterPro; IPR041679; DNA2/NAM7-like_AAA. DR InterPro; IPR041677; DNA2/NAM7_AAA_11. DR InterPro; IPR014808; DNA_replication_fac_Dna2_N. DR InterPro; IPR027417; P-loop_NTPase. DR PANTHER; PTHR10887:SF433; PTHR10887:SF433; 1. DR Pfam; PF13086; AAA_11; 2. DR Pfam; PF13087; AAA_12; 1. DR Pfam; PF08696; Dna2; 1. DR SUPFAM; SSF52540; SSF52540; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000803}; KW Proteomics identification {ECO:0000213|PeptideAtlas:Q8IRL9}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}. FT DOMAIN 101 297 Dna2. {ECO:0000259|Pfam:PF08696}. FT DOMAIN 637 731 AAA_11. {ECO:0000259|Pfam:PF13086}. FT DOMAIN 735 807 AAA_11. {ECO:0000259|Pfam:PF13086}. FT DOMAIN 815 1054 AAA_12. {ECO:0000259|Pfam:PF13087}. FT REGION 1 23 Disordered. {ECO:0000256|SAM:MobiDB- FT lite}. FT COMPBIAS 9 23 Polar. {ECO:0000256|SAM:MobiDB-lite}. SQ SEQUENCE 1100 AA; 124589 MW; 45AB9774192C19FB CRC64; MATKRVLTPN ILENDNTDVT SSNPQKKFKE QLDFSSDEVE NIDWGDNDDF DLALIAAMDS ISNHRLELTK WQRCEVVRLE QLPNRKGLKV HVKRISGGDP ETADCQLLPP WNCMPMQVGD TVSLLGKWDP SAGCYVVDKE QGYCVSHPDF LISGTTVTGS LFCKRKSVLQ ERFRGLDSGN SVMVIGTLVH ELLQKVLRQK LFDKKHIQSA LQEMLASSSL AHLLYASNLI QVEMEDHLMK FIDPIVSFVA QYVKGEPPSV LLPEVYRGQI HEICDIEENL WVPQLGLKGK VDVSVKVKNQ RQREEIIPLE LKTGRASFSM EHKGQLLLYQ LMHSAQGRDT QSGLLLYLKE GLLREVASGR NEQRDLLMLR NDLAYWLTRE VAIPASKEDP LEQLPLPEPV YHHSACGNCA YNTICSSFAQ KDSSLQLSDS HPLKKLMPQL LEHLSEADHA YVQHWCGLLA LEEQHNRQSS HVRSFWTKDP AEREKEGIAI RHLKLVKGQE VILEEGRYRQ TLELGEEADP SRDLSLSGFD LGEYVVISST SRLAVAAGFI VSIEARRLDL RLERDLSQRY SEETFIIDKH DSQSFATFNF TNLGMLLSEG ERFQELRDII VAKKPPEQHK VLPKIILTKG APILLNLNKV QQNAALRALT TSSHLLIKGL PGTGKTQTLV ALVRLLHLLG KSVLITAQTH SAVDNLIMRL LPFGLPMMRL GSGSRIHKQL EEISEERLTK DCKTVEELEK ALGQPSIVGV TCLGCGHPLF QRRQFDYCIV DEATQVLQPT VLRPLIHCSK FVLVGDPEQL PPIVRSKEAR QRGADETLFQ RLDSEKATAV LSLQYRMNKT ITRLANELTY GGDLKCASDE VSGARFEVEL LNEAPRWVQR ALTTHLEQAV TLINTGDCLE RCQEFVYASQ RLVDTCSSIE QSFSEDKDEI RKLTSKKRVS KYTNYCEAGI VMHLLRYLLK SGYEASRIGV IAPYRAQVEL FKKLASKLDT DLECNTVDQF QGRDKNLIIY SCSKTGGDFS DMERSREAEI LEDQRRLTVA ITRAKNKLIL LGDIKCLEQY GPFRQLFKHI PDRCRLKLEE GRMEFGWQRI QEDLVGLMDT //