ID   Q8IRL9_DROME            Unreviewed;      1100 AA.
AC   Q8IRL9;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   15-FEB-2017, entry version 109.
DE   SubName: Full=CG2990, isoform B {ECO:0000313|EMBL:AAN09623.1};
DE            EC=3.6.1.3 {ECO:0000313|EMBL:AAN09623.1};
DE   SubName: Full=FI06813p {ECO:0000313|EMBL:ACS78060.1};
GN   Name=CG2990-RB {ECO:0000313|EMBL:ACS78060.1};
GN   ORFNames=CG2990 {ECO:0000313|EMBL:AAN09623.1,
GN   ECO:0000313|FlyBase:FBgn0030170}, Dmel_CG2990
GN   {ECO:0000313|EMBL:AAN09623.1};
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227 {ECO:0000313|EMBL:AAN09623.1, ECO:0000313|Proteomes:UP000000803};
RN   [1] {ECO:0000313|EMBL:AAN09623.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
RA   Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D.,
RA   Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L.,
RA   Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D.,
RA   Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
RA   Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
RA   Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
RA   Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
RA   Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
RA   de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
RA   Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
RA   Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
RA   Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
RA   Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J.,
RA   Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C.,
RA   Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
RA   Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z.,
RA   Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X.,
RA   Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
RA   Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
RA   Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
RA   Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
RA   Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
RA   Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA   Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
RA   Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
RA   Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
RA   Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J.,
RA   Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
RA   Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O.,
RA   Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2] {ECO:0000313|EMBL:AAN09623.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537568;
RA   Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA   Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA   George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA   Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA   Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA   Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT   "Finishing a whole-genome shotgun: release 3 of the Drosophila
RT   melanogaster euchromatic genome sequence.";
RL   Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN   [3] {ECO:0000313|EMBL:AAN09623.1, ECO:0000313|Proteomes:UP000000803}
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
RA   Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
RA   Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a
RT   systematic review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4] {ECO:0000313|EMBL:AAN09623.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537573;
RA   Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA   Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M.,
RA   Ashburner M., Celniker S.E.;
RT   "The transposable elements of the Drosophila melanogaster euchromatin:
RT   a genomics perspective.";
RL   Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN   [5] {ECO:0000313|EMBL:AAN09623.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537574;
RA   Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA   Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA   Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA   Karpen G.H.;
RT   "Heterochromatic sequences in a Drosophila whole-genome shotgun
RT   assembly.";
RL   Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN   [6] {ECO:0000313|EMBL:AAN09623.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA   Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA   Ashburner M., Anxolabehere D.;
RT   "Combined evidence annotation of transposable elements in genome
RT   sequences.";
RL   PLoS Comput. Biol. 1:166-175(2005).
RN   [7] {ECO:0000313|EMBL:AAN09623.1}
RP   NUCLEOTIDE SEQUENCE.
RG   Berkeley Drosophila Genome Project;
RA   Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R.,
RA   Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E.,
RA   Yu C., Rubin G.;
RT   "Drosophila melanogaster release 4 sequence.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN   [8] {ECO:0000313|EMBL:AAN09623.1}
RP   NUCLEOTIDE SEQUENCE.
RA   O'Boyle S.T.;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN   [9] {ECO:0000313|EMBL:AAN09623.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=17569856; DOI=10.1126/science.1139815;
RA   Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT   "The Release 5.1 annotation of Drosophila melanogaster
RT   heterochromatin.";
RL   Science 316:1586-1591(2007).
RN   [10] {ECO:0000313|EMBL:AAN09623.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=17569867; DOI=10.1126/science.1139816;
RA   Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA   Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA   Dimitri P., Karpen G.H., Celniker S.E.;
RT   "Sequence finishing and mapping of Drosophila melanogaster
RT   heterochromatin.";
RL   Science 316:1625-1628(2007).
RN   [11] {ECO:0000313|EMBL:ACS78060.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.;
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [12] {ECO:0000313|EMBL:AAN09623.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Millard Andrew;
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AE014298; AAN09623.1; -; Genomic_DNA.
DR   EMBL; BT088860; ACS78060.1; -; mRNA.
DR   RefSeq; NP_727386.1; NM_167214.2.
DR   UniGene; Dm.17561; -.
DR   STRING; 7227.FBpp0071350; -.
DR   EnsemblMetazoa; FBtr0071415; FBpp0071350; FBgn0030170.
DR   GeneID; 31934; -.
DR   UCSC; CG2990-RB; d. melanogaster.
DR   FlyBase; FBgn0030170; CG2990.
DR   eggNOG; KOG1805; Eukaryota.
DR   eggNOG; COG1112; LUCA.
DR   GeneTree; ENSGT00780000122010; -.
DR   OMA; HWCGLLA; -.
DR   OrthoDB; EOG091G01N1; -.
DR   Reactome; R-DME-69166; Removal of the Flap Intermediate.
DR   GenomeRNAi; 31934; -.
DR   Proteomes; UP000000803; Chromosome X.
DR   Bgee; FBgn0030170; -.
DR   GO; GO:0017108; F:5'-flap endonuclease activity; IEA:InterPro.
DR   GO; GO:0043142; F:single-stranded DNA-dependent ATPase activity; IEA:InterPro.
DR   GO; GO:0033567; P:DNA replication, Okazaki fragment processing; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR026851; Dna2.
DR   InterPro; IPR014808; DNA_replication_fac_Dna2_N.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR10887:SF415; PTHR10887:SF415; 1.
DR   Pfam; PF08696; Dna2; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000803};
KW   Hydrolase {ECO:0000313|EMBL:AAN09623.1};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:Q8IRL9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000803}.
FT   DOMAIN      101    297       Dna2. {ECO:0000259|Pfam:PF08696}.
SQ   SEQUENCE   1100 AA;  124589 MW;  45AB9774192C19FB CRC64;
     MATKRVLTPN ILENDNTDVT SSNPQKKFKE QLDFSSDEVE NIDWGDNDDF DLALIAAMDS
     ISNHRLELTK WQRCEVVRLE QLPNRKGLKV HVKRISGGDP ETADCQLLPP WNCMPMQVGD
     TVSLLGKWDP SAGCYVVDKE QGYCVSHPDF LISGTTVTGS LFCKRKSVLQ ERFRGLDSGN
     SVMVIGTLVH ELLQKVLRQK LFDKKHIQSA LQEMLASSSL AHLLYASNLI QVEMEDHLMK
     FIDPIVSFVA QYVKGEPPSV LLPEVYRGQI HEICDIEENL WVPQLGLKGK VDVSVKVKNQ
     RQREEIIPLE LKTGRASFSM EHKGQLLLYQ LMHSAQGRDT QSGLLLYLKE GLLREVASGR
     NEQRDLLMLR NDLAYWLTRE VAIPASKEDP LEQLPLPEPV YHHSACGNCA YNTICSSFAQ
     KDSSLQLSDS HPLKKLMPQL LEHLSEADHA YVQHWCGLLA LEEQHNRQSS HVRSFWTKDP
     AEREKEGIAI RHLKLVKGQE VILEEGRYRQ TLELGEEADP SRDLSLSGFD LGEYVVISST
     SRLAVAAGFI VSIEARRLDL RLERDLSQRY SEETFIIDKH DSQSFATFNF TNLGMLLSEG
     ERFQELRDII VAKKPPEQHK VLPKIILTKG APILLNLNKV QQNAALRALT TSSHLLIKGL
     PGTGKTQTLV ALVRLLHLLG KSVLITAQTH SAVDNLIMRL LPFGLPMMRL GSGSRIHKQL
     EEISEERLTK DCKTVEELEK ALGQPSIVGV TCLGCGHPLF QRRQFDYCIV DEATQVLQPT
     VLRPLIHCSK FVLVGDPEQL PPIVRSKEAR QRGADETLFQ RLDSEKATAV LSLQYRMNKT
     ITRLANELTY GGDLKCASDE VSGARFEVEL LNEAPRWVQR ALTTHLEQAV TLINTGDCLE
     RCQEFVYASQ RLVDTCSSIE QSFSEDKDEI RKLTSKKRVS KYTNYCEAGI VMHLLRYLLK
     SGYEASRIGV IAPYRAQVEL FKKLASKLDT DLECNTVDQF QGRDKNLIIY SCSKTGGDFS
     DMERSREAEI LEDQRRLTVA ITRAKNKLIL LGDIKCLEQY GPFRQLFKHI PDRCRLKLEE
     GRMEFGWQRI QEDLVGLMDT
//