ID Q8HH97_GALVR Unreviewed; 598 AA. AC Q8HH97; DT 01-MAR-2003, integrated into UniProtKB/TrEMBL. DT 01-MAR-2003, sequence version 1. DT 08-MAY-2019, entry version 72. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 5 {ECO:0000256|RuleBase:RU003404, ECO:0000256|SAAS:SAAS00061106}; DE EC=7.1.1.2 {ECO:0000256|RuleBase:RU003404}; OS Galeopterus variegatus (Malayan flying lemur) (Cynocephalus OS variegatus). OG Mitochondrion {ECO:0000313|EMBL:AAN84907.1}. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Dermoptera; Cynocephalidae; OC Galeopterus. OX NCBI_TaxID=482537 {ECO:0000313|EMBL:AAN84907.1}; RN [1] {ECO:0000313|EMBL:AAN84907.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=12446821; RA Schmitz J., Ohme M., Suryobroto B., Zischler H.; RT "The colugo (Cynocephalus variegatus, Dermoptera): the primates' RT gliding sister?"; RL Mol. Biol. Evol. 19:2308-2312(2002). CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory CC chain NADH dehydrogenase (Complex I) that is believed to belong to CC the minimal assembly required for catalysis. Complex I functions CC in the transfer of electrons from NADH to the respiratory chain. CC The immediate electron acceptor for the enzyme is believed to be CC ubiquinone. {ECO:0000256|RuleBase:RU003404, CC ECO:0000256|SAAS:SAAS00061107}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 CC H(+)(out) + NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, CC Rhea:RHEA-COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, CC ChEBI:CHEBI:17976, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; CC EC=7.1.1.2; Evidence={ECO:0000256|RuleBase:RU003404, CC ECO:0000256|SAAS:SAAS01122516}; CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane CC {ECO:0000256|SAAS:SAAS00061113}; Multi-pass membrane protein CC {ECO:0000256|SAAS:SAAS00061113}. CC -!- SIMILARITY: Belongs to the complex I subunit 5 family. CC {ECO:0000256|RuleBase:RU003404, ECO:0000256|SAAS:SAAS00546322}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF460846; AAN84907.1; -; Genomic_DNA. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell. DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro. DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro. DR InterPro; IPR010934; NADH_DH_su5_C. DR InterPro; IPR003945; NADHpl_OxRdtase_5. DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr. DR InterPro; IPR001750; ND/Mrp_mem. DR InterPro; IPR001516; Proton_antipo_N. DR Pfam; PF06455; NADH5_C; 1. DR Pfam; PF00361; Proton_antipo_M; 1. DR Pfam; PF00662; Proton_antipo_N; 1. DR PRINTS; PR01435; NPOXDRDTASE5. DR TIGRFAMs; TIGR01974; NDH_I_L; 1. PE 3: Inferred from homology; KW Electron transport {ECO:0000256|SAAS:SAAS00448190}; KW Membrane {ECO:0000256|RuleBase:RU003404, KW ECO:0000256|SAAS:SAAS00464283}; KW Mitochondrion {ECO:0000256|RuleBase:RU003404, KW ECO:0000256|SAAS:SAAS00061115, ECO:0000313|EMBL:AAN84907.1}; KW Mitochondrion inner membrane {ECO:0000256|SAAS:SAAS00448105}; KW NAD {ECO:0000256|RuleBase:RU003404, ECO:0000256|SAAS:SAAS00448053}; KW Respiratory chain {ECO:0000256|SAAS:SAAS00448195}; KW Translocase {ECO:0000256|SAAS:SAAS01106877}; KW Transmembrane {ECO:0000256|RuleBase:RU003404, KW ECO:0000256|SAAS:SAAS00464191}; KW Transmembrane helix {ECO:0000256|RuleBase:RU003404, KW ECO:0000256|SAAS:SAAS00464492}; KW Transport {ECO:0000256|RuleBase:RU003404, KW ECO:0000256|SAAS:SAAS00448204}; KW Ubiquinone {ECO:0000256|RuleBase:RU003404, KW ECO:0000256|SAAS:SAAS00448240}. FT TRANSMEM 6 23 Helical. {ECO:0000256|RuleBase:RU003404}. FT TRANSMEM 35 52 Helical. {ECO:0000256|RuleBase:RU003404}. FT TRANSMEM 79 100 Helical. {ECO:0000256|RuleBase:RU003404}. FT TRANSMEM 112 129 Helical. {ECO:0000256|RuleBase:RU003404}. FT TRANSMEM 135 154 Helical. {ECO:0000256|RuleBase:RU003404}. FT TRANSMEM 166 185 Helical. {ECO:0000256|RuleBase:RU003404}. FT TRANSMEM 205 228 Helical. {ECO:0000256|RuleBase:RU003404}. FT TRANSMEM 240 262 Helical. {ECO:0000256|RuleBase:RU003404}. FT TRANSMEM 268 289 Helical. {ECO:0000256|RuleBase:RU003404}. FT TRANSMEM 296 314 Helical. {ECO:0000256|RuleBase:RU003404}. FT TRANSMEM 320 342 Helical. {ECO:0000256|RuleBase:RU003404}. FT TRANSMEM 363 381 Helical. {ECO:0000256|RuleBase:RU003404}. FT TRANSMEM 401 427 Helical. {ECO:0000256|RuleBase:RU003404}. FT TRANSMEM 479 501 Helical. {ECO:0000256|RuleBase:RU003404}. FT TRANSMEM 513 532 Helical. {ECO:0000256|RuleBase:RU003404}. FT TRANSMEM 579 597 Helical. {ECO:0000256|RuleBase:RU003404}. FT DOMAIN 60 116 Proton_antipo_N. {ECO:0000259|Pfam: FT PF00662}. FT DOMAIN 129 414 Proton_antipo_M. {ECO:0000259|Pfam: FT PF00361}. FT DOMAIN 417 597 NADH5_C. {ECO:0000259|Pfam:PF06455}. SQ SEQUENCE 598 AA; 67526 MW; C8F5BCD0B0588F85 CRC64; MNMTLSLMMI TLTILIIPTL SSMHKRYPHH VKTSTQIAFL TSLTPALMFI YSNQDTTISN WHWITIQTLE LSLSFKLDYL SMVFTPTALF VTWSIMEFSL WYMKSDPNIN KFFKYLLIFL IMMLILTSAN NLLQLLIGWE GVGIMSFLLI GWWYSRTDAN TAALQAIIYN RIGDIGFILT MAWFFMYSNT WNLQQLFALN TDPNLIPLMG LLLAAAGKSA QFGLHPWLPS AMEGPTPVSA LLHSSTMVVA GIFLLIRFYP LMENNKTIQT LTLCLGALTT LFMAICALTQ NDIKKIIAFS TSSQLGLMMV TIGINQPYLA FLHICMHAFF KAMLFMCSGS IIHNLNNEQD IRKMGGLYKI MPLTSTSLVI GSLALTGMPF LTGFYSKDLI IETMNMSYTN AWALTITLIA TALTAAYSTR IIFLTLLEQP RFPTLMNMNE NNPHLTNPTK RLMIGSMFAG FIISNNIPPM DIPQMTMPLY LKLSTLLITI LGLTLALELC LNSLNLNPKL PSPLHSFSTL LGFFPILTHR MMPYLNLTMS QYMVSQTLDS TWLEKTIPKN TAHFQMLAAT NISNQKGLIK LYFLSFLITI TMMMLLMI //