ID ETR2_ORYSI Reviewed; 763 AA. AC Q8H1X1; A2XQB6; DT 16-SEP-2015, integrated into UniProtKB/Swiss-Prot. DT 16-SEP-2015, sequence version 3. DT 28-FEB-2018, entry version 98. DE RecName: Full=Ethylene receptor 2 {ECO:0000305}; DE Short=OS-ETR2 {ECO:0000303|PubMed:14754915}; DE EC=2.7.13.3 {ECO:0000305}; DE AltName: Full=OsETRL1 {ECO:0000312|EMBL:AAN15203.2}; DE AltName: Full=Protein ETYLENE RESPONSE 2-LIKE 1 {ECO:0000303|PubMed:15020633}; DE Short=Os-ERL1 {ECO:0000303|PubMed:15020633}; GN Name=ETR2 {ECO:0000312|EMBL:AAN15203.2}; OS Oryza sativa subsp. indica (Rice). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae; BOP clade; OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa. OX NCBI_TaxID=39946; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INDUCTION BY RP ETHYLENE. RC STRAIN=cv. IR36; RX PubMed=14754915; DOI=10.1093/jxb/erh055; RA Yau C.P., Wang L., Yu M., Zee S.Y., Yip W.K.; RT "Differential expression of three genes encoding an ethylene receptor RT in rice during development, and in response to indole-3-acetic acid RT and silver ions."; RL J. Exp. Bot. 55:547-556(2004). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA], AND INDUCTION. RC STRAIN=cv. Pin Gaew 56; TISSUE=Stem; RX PubMed=15020633; DOI=10.1093/jxb/erh110; RA Watanabe H., Saigusa M., Hase S., Hayakawa T., Satoh S.; RT "Cloning of a cDNA encoding an ETR2-like protein (Os-ERL1) from deep RT water rice (Oryza sativa L.) and increase in its mRNA level by RT submergence, ethylene, and gibberellin treatments."; RL J. Exp. Bot. 55:1145-1148(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. 93-11; RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038; RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., RA Cong L., Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., RA Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., RA Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., RA Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., RA Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., RA Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., RA Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., RA Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., RA Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., RA Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., RA Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., RA Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., RA Samudrala R., Wang J., Wong G.K.-S., Yang H.; RT "The genomes of Oryza sativa: a history of duplications."; RL PLoS Biol. 3:266-281(2005). CC -!- FUNCTION: Ethylene receptor related to bacterial two-component CC regulators. Acts as negative regulator of ethylene signaling. May CC delay the transition from the vegetative stage to the floral stage CC by upregulating GI (GIGANTEA) and RCN1 and cause starch CC accumulation in stems by down-regulating the alpha-amylase AMY3D. CC {ECO:0000250|UniProtKB:Q7XX84}. CC -!- CATALYTIC ACTIVITY: ATP + protein L-histidine = ADP + protein N- CC phospho-L-histidine. {ECO:0000305}. CC -!- COFACTOR: CC Name=Cu cation; Xref=ChEBI:CHEBI:23378; CC Evidence={ECO:0000250|UniProtKB:P49333}; CC Note=Binds 1 copper ion per dimer. {ECO:0000250|UniProtKB:P49333}; CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane CC {ECO:0000250|UniProtKB:P49333}; Multi-pass membrane protein CC {ECO:0000255}. CC -!- TISSUE SPECIFICITY: Expressed in anthers and hulls. CC {ECO:0000269|PubMed:14754915}. CC -!- INDUCTION: By ethylene and auxin (PubMed:14754915). Induced by CC submergence, ethylene and gibberellin (PubMed:15020633). CC {ECO:0000269|PubMed:14754915, ECO:0000269|PubMed:15020633}. CC -!- SIMILARITY: Belongs to the ethylene receptor family. CC {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=EAY93026.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY136816; AAN15203.2; -; mRNA. DR EMBL; AB107219; BAF51961.1; -; mRNA. DR EMBL; CM000129; EAY93026.1; ALT_SEQ; Genomic_DNA. DR SMR; Q8H1X1; -. DR eggNOG; KOG0519; Eukaryota. DR eggNOG; COG0642; LUCA. DR OrthoDB; EOG093602TA; -. DR Proteomes; UP000007015; Chromosome 4. DR ExpressionAtlas; Q8H1X1; baseline and differential. DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0051740; F:ethylene binding; IEA:InterPro. DR GO; GO:0038199; F:ethylene receptor activity; IEA:InterPro. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro. DR GO; GO:0010105; P:negative regulation of ethylene-activated signaling pathway; IEA:InterPro. DR CDD; cd00156; REC; 1. DR Gene3D; 3.30.450.40; -; 1. DR Gene3D; 3.30.565.10; -; 1. DR InterPro; IPR011006; CheY-like_superfamily. DR InterPro; IPR014525; ETR. DR InterPro; IPR003018; GAF. DR InterPro; IPR029016; GAF-like_dom_sf. DR InterPro; IPR036890; HATPase_C_sf. DR InterPro; IPR005467; His_kinase_dom. DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver. DR Pfam; PF01590; GAF; 1. DR Pfam; PF00072; Response_reg; 1. DR PIRSF; PIRSF026389; Ethyln_sen_HK; 1. DR SMART; SM00065; GAF; 1. DR SMART; SM00448; REC; 1. DR SUPFAM; SSF52172; SSF52172; 1. DR SUPFAM; SSF55874; SSF55874; 1. DR PROSITE; PS50109; HIS_KIN; 1. DR PROSITE; PS50110; RESPONSE_REGULATORY; 1. PE 2: Evidence at transcript level; KW ATP-binding; Complete proteome; Copper; Disulfide bond; KW Endoplasmic reticulum; Ethylene signaling pathway; Kinase; Membrane; KW Metal-binding; Nucleotide-binding; Phosphoprotein; Receptor; KW Reference proteome; Transferase; Transmembrane; Transmembrane helix; KW Two-component regulatory system. FT CHAIN 1 763 Ethylene receptor 2. FT /FTId=PRO_0000433866. FT TRANSMEM 58 78 Helical. {ECO:0000255}. FT TRANSMEM 86 106 Helical. {ECO:0000255}. FT TRANSMEM 115 135 Helical. {ECO:0000255}. FT DOMAIN 190 339 GAF. {ECO:0000305}. FT DOMAIN 382 615 Histidine kinase. {ECO:0000255|PROSITE- FT ProRule:PRU00107}. FT DOMAIN 641 760 Response regulatory. FT {ECO:0000255|PROSITE-ProRule:PRU00169}. FT METAL 97 97 Copper. {ECO:0000250|UniProtKB:P49333}. FT METAL 101 101 Copper. {ECO:0000250|UniProtKB:P49333}. FT MOD_RES 692 692 4-aspartylphosphate. FT {ECO:0000255|PROSITE-ProRule:PRU00169}. FT DISULFID 31 31 Interchain. FT {ECO:0000250|UniProtKB:P49333}. FT DISULFID 34 34 Interchain. FT {ECO:0000250|UniProtKB:P49333}. FT CONFLICT 351 351 I -> M (in Ref. 2; BAF51961 and 1; FT AAN15203). FT CONFLICT 453 453 L -> S (in Ref. 2; BAF51961 and 1; FT AAN15203). SQ SEQUENCE 763 AA; 84840 MW; 2A1B9837BFBA71CC CRC64; MPPIPSLWIR VFFSWLLLSL PAAAAADFSH CGGCDDGDGG GGIWSTDNIL QCQRVSDFLI AMAYFSIPLE LLYFATCSDL FPLKWIVLQF GAFIVLCGLT HLITMFTYEP HSFHVVLALT VAKFLTALVS FATAITLLTL IPQLLRVKVR ENFLRIKARE LDREVGMMKR QEEASWHVRM LTHEIRKSLD RHTILYTTMV ELSKTLELQN CAVWMPSESG SEMILTHQLR QMETEDSNSL SIAMDNPDVL EIKATKDAKV LAADSALGIA SRGKLEAGPV AAIRMPMLKA SNFKGGTPEV METSYAILVL VLPEDGSLGW GEEELEIVEV VADQVAVALS HAAVLEESQL IREKLAAQHR DLLRAKHETT MATEARNSFQ TAMYDGMRRP MHSILGLVSM MQQENMNPEQ RLVMDAIVKT SSVASTLMND VMQTSTVNRE YLSLVRRAFN LHLLVKEAIS VVRCLTGCKG IDFEFEVDNS LPERVVGDEK RVFHIVLHMV GTLIQRCNAG CLSLYVNTYN EKEERHNQDW MLRRANFSGS YVCVKFEIRI RESRGNLLSS SSSRRLQGPN STSSEMGLSF NMCKKIVQMM NGNIWSVSDS KGLGETIMLA LQFQLQHVTP VSGASSDLFR SAPIPNFNGL QVILVDSDDT NRAVTHKLLE KLGCLVLSVT SGIQCINSFA SAESSFQLVV LDLTMRTMDG FDVALAIRKF RGNCWPPLIV ALAASTDDTV RDRCQQAGIN GLIQKPVTLA ALGDELYRVL QNN //