ID MOS14_ARATH Reviewed; 958 AA. AC Q8GUL2; Q9FJI6; DT 06-JUL-2016, integrated into UniProtKB/Swiss-Prot. DT 01-MAR-2003, sequence version 1. DT 07-APR-2021, entry version 127. DE RecName: Full=Transportin MOS14 {ECO:0000305}; DE AltName: Full=Importin beta MOS14 {ECO:0000305}; DE AltName: Full=Protein MODIFIER OF SNC1 14 {ECO:0000303|PubMed:21738492}; DE AltName: Full=Transportin-SR {ECO:0000303|PubMed:21738492}; DE Short=TRN-SR {ECO:0000303|PubMed:21738492}; GN Name=MOS14 {ECO:0000303|PubMed:21738492}; GN OrderedLocusNames=At5g62600 {ECO:0000312|Araport:AT5G62600}; GN ORFNames=K19B1.21 {ECO:0000312|EMBL:BAB11510.1}; OS Arabidopsis thaliana (Mouse-ear cress). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis. OX NCBI_TaxID=3702; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Columbia; RX PubMed=9872454; DOI=10.1093/dnares/5.5.297; RA Nakamura Y., Sato S., Asamizu E., Kaneko T., Kotani H., Miyajima N., RA Tabata S.; RT "Structural analysis of Arabidopsis thaliana chromosome 5. VII. Sequence RT features of the regions of 1,013,767 bp covered by sixteen physically RT assigned P1 and TAC clones."; RL DNA Res. 5:297-308(1998). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Columbia; RX PubMed=10718197; DOI=10.1093/dnares/7.1.31; RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H., RA Tabata S.; RT "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence RT features of the regions of 3,076,755 bp covered by sixty P1 and TAC RT clones."; RL DNA Res. 7:31-63(2000). RN [3] RP GENOME REANNOTATION. RC STRAIN=cv. Columbia; RX PubMed=27862469; DOI=10.1111/tpj.13415; RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S., RA Town C.D.; RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference RT genome."; RL Plant J. 89:789-804(2017). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=cv. Columbia; RX PubMed=14593172; DOI=10.1126/science.1088305; RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L., RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., RA Ecker J.R.; RT "Empirical analysis of transcriptional activity in the Arabidopsis RT genome."; RL Science 302:842-846(2003). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=cv. Columbia; RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K., RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., RA Shinozaki K.; RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."; RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases. RN [6] RP FUNCTION, INTERACTION WITH RS2Z33; RSZ21; RS31A; SR34 AND RAN1, SUBCELLULAR RP LOCATION, AND DISRUPTION PHENOTYPE. RX PubMed=21738492; DOI=10.1371/journal.pgen.1002159; RA Xu S., Zhang Z., Jing B., Gannon P., Ding J., Xu F., Li X., Zhang Y.; RT "Transportin-SR is required for proper splicing of resistance genes and RT plant immunity."; RL PLoS Genet. 7:E1002159-E1002159(2011). CC -!- FUNCTION: Functions as nuclear import receptor for serine-arginine rich CC (SR) proteins. Regulates nuclear import of SR proteins that are CC required for proper splicing of the two resistance (R) genes SNC1 and CC RPS4, a crucial step for their functions in plant immunity. CC {ECO:0000269|PubMed:21738492}. CC -!- SUBUNIT: Interacts with RS2Z33, RSZ21, RS31A, SR34 and RAN1. CC {ECO:0000269|PubMed:21738492}. CC -!- INTERACTION: CC Q8GUL2; Q84MB2: TIFY8; NbExp=3; IntAct=EBI-25520322, EBI-4426557; CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21738492}. CC -!- DISRUPTION PHENOTYPE: Semi-dwarf phenotype. CC {ECO:0000269|PubMed:21738492}. CC -!- SIMILARITY: Belongs to the importin beta family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=BAB11510.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB015469; BAB11510.1; ALT_SEQ; Genomic_DNA. DR EMBL; AB020751; BAB11510.1; JOINED; Genomic_DNA. DR EMBL; CP002688; AED97629.1; -; Genomic_DNA. DR EMBL; BT002408; AAO00768.1; -; mRNA. DR EMBL; BT010552; AAQ65175.1; -; mRNA. DR EMBL; AK229829; BAF01659.1; -; mRNA. DR EMBL; AK230415; BAF02213.1; -; mRNA. DR RefSeq; NP_201066.2; NM_125655.4. DR SMR; Q8GUL2; -. DR IntAct; Q8GUL2; 1. DR STRING; 3702.AT5G62600.1; -. DR PaxDb; Q8GUL2; -. DR PRIDE; Q8GUL2; -. DR ProteomicsDB; 238265; -. DR EnsemblPlants; AT5G62600.1; AT5G62600.1; AT5G62600. DR GeneID; 836381; -. DR Gramene; AT5G62600.1; AT5G62600.1; AT5G62600. DR KEGG; ath:AT5G62600; -. DR Araport; AT5G62600; -. DR TAIR; locus:2154159; AT5G62600. DR eggNOG; KOG2081; Eukaryota. DR HOGENOM; CLU_005996_2_0_1; -. DR InParanoid; Q8GUL2; -. DR OMA; KTINYCR; -. DR OrthoDB; 206228at2759; -. DR PhylomeDB; Q8GUL2; -. DR PRO; PR:Q8GUL2; -. DR Proteomes; UP000006548; Chromosome 5. DR ExpressionAtlas; Q8GUL2; baseline and differential. DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central. DR GO; GO:0005634; C:nucleus; IDA:TAIR. DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro. DR GO; GO:0006606; P:protein import into nucleus; IMP:TAIR. DR GO; GO:0043484; P:regulation of RNA splicing; IMP:TAIR. DR Gene3D; 1.25.10.10; -; 1. DR InterPro; IPR011989; ARM-like. DR InterPro; IPR016024; ARM-type_fold. DR InterPro; IPR013598; Exportin-1/Importin-b-like. DR InterPro; IPR001494; Importin-beta_N. DR Pfam; PF03810; IBN_N; 1. DR Pfam; PF08389; Xpo1; 1. DR SMART; SM00913; IBN_N; 1. DR SUPFAM; SSF48371; SSF48371; 1. PE 1: Evidence at protein level; KW Nucleus; Protein transport; Reference proteome; Transport. FT CHAIN 1..958 FT /note="Transportin MOS14" FT /id="PRO_0000436558" FT DOMAIN 26..93 FT /note="Importin N-terminal" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00115" SQ SEQUENCE 958 AA; 106917 MW; 6C1DC0E753DD7A0B CRC64; MEHQNAVKEA LNALYHHPDD TVRVHADRWL QNFQGTLDAW QVADNLLHDS SSNLETLIFC SQTLRSKVQR DFEELPPGAF QKLRQSLTTL LKKFHKGPPK VRTQISIAVA ALAVHVPAAD WGDGGIISWL RDEMHMHPEY VPGFLELLTV LPEETFNYKI AARPDRRRQF EKELTSQMEA ALSILSACLK ISELKEQVLE AFASWLRLRH GIPGTVLACH PLVHAALSSL NCDPLSEASV NVISELIHHT ASPSSGGISA QTPLIQVIVP QILSLQAHLR DSSKDEEDVK AIGRLFADVG DSYVELIATG SDEPMVIVHA LLEVTAHPEF DIASMTFNFW HSLQLMLTKR ESYSSLGSEA SIEVERNRRL HIFQPAYQSL VSLVGFRVQY PEDYQGLSYE DLKEFKQTRY AVADVLIDAA LILGGDTTLK ILYMKLLEAN AQTGNNFQDW RPAEAILFCI WAISNYVSVV EAEVMPQVMA LLQNLPQQAQ LLQTACLLVG AYSKWLNAAP ASVSILPSII RILMSGMGTS EDCAAAAALA FRHTCDDCRK NLCGYFEDLF NIYCMAINGG GGYKVSAEDS LNLVEALGMV VTELPLDQAK GALEKLCFSA ASPLEEAAKE DLEKKHAREL TVHIDRFAFL FRYVNHPEAV AAEINKHWAI FRVIFDARPW DMRTMESLCR ACKYAVRTSG RYIIDTIGEM LEKIQFHYQQ HHQPCFLYLS SEVIKIFGSD PSCAVYLKNL IETLFAHTTC LMTSIKEVTA RPDIADDCFL LASRCLRYCP HLFIPSPIFP ALVNCAMIGI TVQHREACHS ILTFLTDIFD LEKSVNEEQF VRIRDNIIIP RGATITRILI ASLAGALPSS RLDTVTYSLL ALTRTYRLQA VSWAKESVSL IPRTALTETE STKFLQALSD IAYGADVNSL IGQVEELSDV CRRNRTVQEL VQAALKPLEL NLVTAPVS //