ID IP5P4_ARATH Reviewed; 547 AA. AC Q8GTS0; Q9M1W5; DT 24-JUN-2015, integrated into UniProtKB/Swiss-Prot. DT 01-MAR-2003, sequence version 1. DT 18-JAN-2017, entry version 91. DE RecName: Full=Type I inositol polyphosphate 5-phosphatase 4 {ECO:0000305}; DE Short=At5PTase4 {ECO:0000305}; DE EC=3.1.3.- {ECO:0000305}; GN Name=IP5P4 {ECO:0000305}; GN OrderedLocusNames=At3g63240 {ECO:0000312|TAIR:AT3G63240}; GN ORFNames=F16M2_90 {ECO:0000312|EMBL:CAB86425.1}; OS Arabidopsis thaliana (Mouse-ear cress). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; OC Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; OC Arabidopsis. OX NCBI_TaxID=3702; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Columbia; RX PubMed=11130713; DOI=10.1038/35048706; RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., RA Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., RA Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., RA De Simone V., Choisne N., Artiguenave F., Robert C., Brottier P., RA Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., RA Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., RA Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., RA Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., RA Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., RA Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., RA Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., RA Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., RA Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., RA Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., RA Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., RA Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., RA Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., RA Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., RA Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., RA Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., RA Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., RA Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., RA Watanabe A., Yamada M., Yasuda M., Tabata S.; RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis RT thaliana."; RL Nature 408:820-822(2000). RN [2] RP GENOME REANNOTATION. RC STRAIN=cv. Columbia; RG The Arabidopsis Information Resource (TAIR); RL Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=cv. Columbia; RX PubMed=11910074; DOI=10.1126/science.1071006; RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T., RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., RA Hayashizaki Y., Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., RA Shibata K., Shinagawa A., Shinozaki K.; RT "Functional annotation of a full-length Arabidopsis cDNA collection."; RL Science 296:141-145(2002). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=cv. Columbia; RX PubMed=14593172; DOI=10.1126/science.1088305; RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., RA Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., RA Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G., RA Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., RA Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., RA Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., RA Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., RA Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., RA Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., RA Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., RA Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., RA Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.; RT "Empirical analysis of transcriptional activity in the Arabidopsis RT genome."; RL Science 302:842-846(2003). RN [5] RP GENE FAMILY. RX PubMed=11402208; DOI=10.1104/pp.126.2.801; RA Berdy S.E., Kudla J., Gruissem W., Gillaspy G.E.; RT "Molecular characterization of At5PTase1, an inositol phosphatase RT capable of terminating inositol trisphosphate signaling."; RL Plant Physiol. 126:801-810(2001). CC -!- SIMILARITY: Belongs to the inositol polyphosphate 5-phosphatase CC family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=CAB86425.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL138648; CAB86425.1; ALT_SEQ; Genomic_DNA. DR EMBL; CP002686; AEE80454.1; -; Genomic_DNA. DR EMBL; AK117957; BAC42595.1; -; mRNA. DR EMBL; BT005913; AAO64848.1; -; mRNA. DR PIR; T48113; T48113. DR RefSeq; NP_191883.2; NM_116189.4. DR UniGene; At.33968; -. DR ProteinModelPortal; Q8GTS0; -. DR SMR; Q8GTS0; -. DR STRING; 3702.AT3G63240.1; -. DR PaxDb; Q8GTS0; -. DR EnsemblPlants; AT3G63240.1; AT3G63240.1; AT3G63240. DR EnsemblPlants; AT3G63240.2; AT3G63240.2; AT3G63240. DR GeneID; 825499; -. DR Gramene; AT3G63240.1; AT3G63240.1; AT3G63240. DR Gramene; AT3G63240.2; AT3G63240.2; AT3G63240. DR KEGG; ath:AT3G63240; -. DR TAIR; AT3G63240; -. DR eggNOG; KOG0565; Eukaryota. DR eggNOG; COG5411; LUCA. DR HOGENOM; HOG000241161; -. DR InParanoid; Q8GTS0; -. DR OMA; KSEDFHA; -. DR OrthoDB; EOG0936064A; -. DR PhylomeDB; Q8GTS0; -. DR BioCyc; ARA:AT3G63240-MONOMER; -. DR Reactome; R-ATH-1660499; Synthesis of PIPs at the plasma membrane. DR Reactome; R-ATH-1660514; Synthesis of PIPs at the Golgi membrane. DR Reactome; R-ATH-1855183; Synthesis of IP2, IP, and Ins in the cytosol. DR Reactome; R-ATH-1855204; Synthesis of IP3 and IP4 in the cytosol. DR Reactome; R-ATH-194840; Rho GTPase cycle. DR PRO; PR:Q8GTS0; -. DR Proteomes; UP000006548; Chromosome 3. DR Genevisible; Q8GTS0; AT. DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW. DR GO; GO:0046856; P:phosphatidylinositol dephosphorylation; IEA:InterPro. DR Gene3D; 3.60.10.10; -; 2. DR InterPro; IPR005135; Endo/exonuclease/phosphatase. DR InterPro; IPR000300; IPPc. DR Pfam; PF03372; Exo_endo_phos; 1. DR SMART; SM00128; IPPc; 1. DR SUPFAM; SSF56219; SSF56219; 2. PE 2: Evidence at transcript level; KW Complete proteome; Hydrolase; Reference proteome. FT CHAIN 1 547 Type I inositol polyphosphate 5- FT phosphatase 4. FT /FTId=PRO_0000433255. FT REGION 387 402 Catalytic 1. FT {ECO:0000250|UniProtKB:Q84MA2}. FT REGION 467 482 Catalytic 2. FT {ECO:0000250|UniProtKB:Q84MA2}. SQ SEQUENCE 547 AA; 62177 MW; 13089EA143883A88 CRC64; MGDGNLKKSK LSWPKTLVKK WLNIKSKSED FHADDLDRGE GGGDWRNNVI EREEACSVRK SKTETRSKRN SGRARRNKLD VDPPLDHLRV FTATWNVAGK SPPSYLNLDD WLHTSPPSDI YVLGFQEIVP LNAGNVLGTE DNGPARKWVS LIRRTLNSLP GGSCQTPSPV PHPVAELDSD FEGDSAAGAN SLFYHRSRSM RMDASASSLP QQFDRRFSVC DRFMLGDTPD DFYDQSFRYC SSEDEPADSP CHDHYSPVSR TGSFVADDRD KGRDKSKYCL VASKQMVGIF LTVWVKSDLR DSVNNLKVSC VGRGLMGYLG NKGSISISMS VHQTSFCFVC SHLTSGQKEG DELRRNSDVL EILRKTRFPR VNNAGDDKSP QMISEHDRVI WLGDLNYRIA LSYRSAKALV EMRDWRALLE KDQLRIEQRK GCVFEGWKEG TIYFPPTYKY SNNSDIYAGD DRLPKAKRRT PAWCDRILWH GSGISQLSYV RGESRFSDHR PVYSLFSVEI ESAYRNRIKK SSSYTSSRIE VEELLPQRYG YSELNPY //