ID IP5P4_ARATH Reviewed; 547 AA. AC Q8GTS0; Q9M1W5; DT 24-JUN-2015, integrated into UniProtKB/Swiss-Prot. DT 01-MAR-2003, sequence version 1. DT 22-APR-2020, entry version 109. DE RecName: Full=Type I inositol polyphosphate 5-phosphatase 4 {ECO:0000305}; DE Short=At5PTase4 {ECO:0000305}; DE EC=3.1.3.- {ECO:0000305}; GN Name=IP5P4 {ECO:0000305}; GN OrderedLocusNames=At3g63240 {ECO:0000312|Araport:AT3G63240}; GN ORFNames=F16M2_90 {ECO:0000312|EMBL:CAB86425.1}; OS Arabidopsis thaliana (Mouse-ear cress). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis. OX NCBI_TaxID=3702; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Columbia; RX PubMed=11130713; DOI=10.1038/35048706; RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P., RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., RA Watanabe A., Yamada M., Yasuda M., Tabata S.; RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."; RL Nature 408:820-822(2000). RN [2] RP GENOME REANNOTATION. RC STRAIN=cv. Columbia; RX PubMed=27862469; DOI=10.1111/tpj.13415; RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S., RA Town C.D.; RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference RT genome."; RL Plant J. 89:789-804(2017). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=cv. Columbia; RX PubMed=11910074; DOI=10.1126/science.1071006; RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T., RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y., RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K., RA Shinagawa A., Shinozaki K.; RT "Functional annotation of a full-length Arabidopsis cDNA collection."; RL Science 296:141-145(2002). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=cv. Columbia; RX PubMed=14593172; DOI=10.1126/science.1088305; RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L., RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., RA Ecker J.R.; RT "Empirical analysis of transcriptional activity in the Arabidopsis RT genome."; RL Science 302:842-846(2003). RN [5] RP GENE FAMILY. RX PubMed=11402208; DOI=10.1104/pp.126.2.801; RA Berdy S.E., Kudla J., Gruissem W., Gillaspy G.E.; RT "Molecular characterization of At5PTase1, an inositol phosphatase capable RT of terminating inositol trisphosphate signaling."; RL Plant Physiol. 126:801-810(2001). CC -!- SIMILARITY: Belongs to the inositol polyphosphate 5-phosphatase family. CC {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=CAB86425.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL138648; CAB86425.1; ALT_SEQ; Genomic_DNA. DR EMBL; CP002686; AEE80454.1; -; Genomic_DNA. DR EMBL; CP002686; ANM64742.1; -; Genomic_DNA. DR EMBL; AK117957; BAC42595.1; -; mRNA. DR EMBL; BT005913; AAO64848.1; -; mRNA. DR PIR; T48113; T48113. DR RefSeq; NP_001326750.1; NM_001340194.1. DR RefSeq; NP_191883.2; NM_116189.4. DR STRING; 3702.AT3G63240.1; -. DR PaxDb; Q8GTS0; -. DR EnsemblPlants; AT3G63240.1; AT3G63240.1; AT3G63240. DR EnsemblPlants; AT3G63240.2; AT3G63240.2; AT3G63240. DR GeneID; 825499; -. DR Gramene; AT3G63240.1; AT3G63240.1; AT3G63240. DR Gramene; AT3G63240.2; AT3G63240.2; AT3G63240. DR KEGG; ath:AT3G63240; -. DR Araport; AT3G63240; -. DR TAIR; locus:2077314; AT3G63240. DR eggNOG; KOG0565; Eukaryota. DR eggNOG; COG5411; LUCA. DR HOGENOM; CLU_011711_4_0_1; -. DR InParanoid; Q8GTS0; -. DR OMA; YLNLDDW; -. DR OrthoDB; 1399831at2759; -. DR PhylomeDB; Q8GTS0; -. DR BioCyc; ARA:AT3G63240-MONOMER; -. DR PRO; PR:Q8GTS0; -. DR Proteomes; UP000006548; Chromosome 3. DR ExpressionAtlas; Q8GTS0; baseline and differential. DR Genevisible; Q8GTS0; AT. DR GO; GO:0034485; F:phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity; IBA:GO_Central. DR GO; GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IBA:GO_Central. DR GO; GO:0046856; P:phosphatidylinositol dephosphorylation; IBA:GO_Central. DR Gene3D; 3.60.10.10; -; 2. DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf. DR InterPro; IPR005135; Endo/exonuclease/phosphatase. DR InterPro; IPR000300; IPPc. DR Pfam; PF03372; Exo_endo_phos; 1. DR SMART; SM00128; IPPc; 1. DR SUPFAM; SSF56219; SSF56219; 1. PE 2: Evidence at transcript level; KW Hydrolase; Reference proteome. FT CHAIN 1..547 FT /note="Type I inositol polyphosphate 5-phosphatase 4" FT /id="PRO_0000433255" FT REGION 387..402 FT /note="Catalytic 1" FT /evidence="ECO:0000250|UniProtKB:Q84MA2" FT REGION 467..482 FT /note="Catalytic 2" FT /evidence="ECO:0000250|UniProtKB:Q84MA2" SQ SEQUENCE 547 AA; 62177 MW; 13089EA143883A88 CRC64; MGDGNLKKSK LSWPKTLVKK WLNIKSKSED FHADDLDRGE GGGDWRNNVI EREEACSVRK SKTETRSKRN SGRARRNKLD VDPPLDHLRV FTATWNVAGK SPPSYLNLDD WLHTSPPSDI YVLGFQEIVP LNAGNVLGTE DNGPARKWVS LIRRTLNSLP GGSCQTPSPV PHPVAELDSD FEGDSAAGAN SLFYHRSRSM RMDASASSLP QQFDRRFSVC DRFMLGDTPD DFYDQSFRYC SSEDEPADSP CHDHYSPVSR TGSFVADDRD KGRDKSKYCL VASKQMVGIF LTVWVKSDLR DSVNNLKVSC VGRGLMGYLG NKGSISISMS VHQTSFCFVC SHLTSGQKEG DELRRNSDVL EILRKTRFPR VNNAGDDKSP QMISEHDRVI WLGDLNYRIA LSYRSAKALV EMRDWRALLE KDQLRIEQRK GCVFEGWKEG TIYFPPTYKY SNNSDIYAGD DRLPKAKRRT PAWCDRILWH GSGISQLSYV RGESRFSDHR PVYSLFSVEI ESAYRNRIKK SSSYTSSRIE VEELLPQRYG YSELNPY //