ID   KITH_MYCPE              Reviewed;         220 AA.
AC   Q8EU99;
DT   07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   13-NOV-2013, entry version 63.
DE   RecName: Full=Thymidine kinase;
DE            EC=2.7.1.21;
GN   Name=tdk; OrderedLocusNames=MYPE10320;
OS   Mycoplasma penetrans (strain HF-2).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=272633;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HF-2;
RX   PubMed=12466555; DOI=10.1093/nar/gkf667;
RA   Sasaki Y., Ishikawa J., Yamashita A., Oshima K., Kenri T., Furuya K.,
RA   Yoshino C., Horino A., Shiba T., Sasaki T., Hattori M.;
RT   "The complete genomic sequence of Mycoplasma penetrans, an
RT   intracellular bacterial pathogen in humans.";
RL   Nucleic Acids Res. 30:5293-5300(2002).
CC   -!- CATALYTIC ACTIVITY: ATP + thymidine = ADP + thymidine 5'-
CC       phosphate.
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Potential).
CC   -!- SIMILARITY: Belongs to the thymidine kinase family.
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DR   EMBL; BA000026; BAC44817.1; -; Genomic_DNA.
DR   RefSeq; NP_758413.1; NC_004432.1.
DR   ProteinModelPortal; Q8EU99; -.
DR   STRING; 272633.MYPE10320; -.
DR   EnsemblBacteria; BAC44817; BAC44817; BAC44817.
DR   GeneID; 1041069; -.
DR   KEGG; mpe:MYPE10320; -.
DR   PATRIC; 20021252; VBIMycPen56664_1056.
DR   eggNOG; COG1435; -.
DR   HOGENOM; HOG000076390; -.
DR   KO; K00857; -.
DR   OMA; KVHAICV; -.
DR   OrthoDB; EOG69D3J2; -.
DR   BioCyc; MPEN272633:GJBP-1059-MONOMER; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0004797; F:thymidine kinase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   HAMAP; MF_00124; Thymidine_kinase; 1; -.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001267; Thymidine_kinase.
DR   InterPro; IPR020633; Thymidine_kinase_CS.
DR   InterPro; IPR020634; Thymidine_kinase_subgr.
DR   PANTHER; PTHR11441; PTHR11441; 1.
DR   Pfam; PF00265; TK; 1.
DR   PIRSF; PIRSF035805; TK_cell; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00603; TK_CELLULAR_TYPE; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA synthesis; Kinase;
KW   Metal-binding; Nucleotide-binding; Transferase; Zinc.
FT   CHAIN         1    220       Thymidine kinase.
FT                                /FTId=PRO_0000174998.
FT   NP_BIND      18     25       ATP (By similarity).
FT   NP_BIND      93     96       ATP (By similarity).
FT   ACT_SITE     94     94       Proton acceptor (Potential).
FT   METAL       150    150       Zinc (By similarity).
FT   METAL       153    153       Zinc (By similarity).
FT   METAL       188    188       Zinc (By similarity).
FT   METAL       191    191       Zinc (By similarity).
SQ   SEQUENCE   220 AA;  25184 MW;  47CFA4901E74737F CRC64;
     MKNNAFGKEK GWIELIYGPM FAGKSEELLR KLKRLDYADV IYQVFKPKID TRTKNKIMSR
     DGRNMDSFEF DNPYEIFDKL LSLEVNPHVV AIDEAQFADE SIVDVCQALA DSGYIVYVSA
     LDKNFKNEPF MVTAKIACIA EYVEKLSAIC TDCGAPGTAT QRIINDKPSN YDEPVVQIGN
     YETYTVKCRH HHKIPGKPFP EEIKKFKSDL RNLLKNKENK
//