ID KITH_MYCPE Reviewed; 220 AA. AC Q8EU99; DT 07-NOV-2003, integrated into UniProtKB/Swiss-Prot. DT 01-MAR-2003, sequence version 1. DT 01-MAY-2013, entry version 60. DE RecName: Full=Thymidine kinase; DE EC=2.7.1.21; GN Name=tdk; OrderedLocusNames=MYPE10320; OS Mycoplasma penetrans (strain HF-2). OC Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma. OX NCBI_TaxID=272633; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=HF-2; RX PubMed=12466555; DOI=10.1093/nar/gkf667; RA Sasaki Y., Ishikawa J., Yamashita A., Oshima K., Kenri T., Furuya K., RA Yoshino C., Horino A., Shiba T., Sasaki T., Hattori M.; RT "The complete genomic sequence of Mycoplasma penetrans, an RT intracellular bacterial pathogen in humans."; RL Nucleic Acids Res. 30:5293-5300(2002). CC -!- CATALYTIC ACTIVITY: ATP + thymidine = ADP + thymidine 5'- CC phosphate. CC -!- SUBUNIT: Homotetramer (By similarity). CC -!- SUBCELLULAR LOCATION: Cytoplasm (Potential). CC -!- SIMILARITY: Belongs to the thymidine kinase family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BA000026; BAC44817.1; -; Genomic_DNA. DR RefSeq; NP_758413.1; NC_004432.1. DR ProteinModelPortal; Q8EU99; -. DR STRING; 272633.MYPE10320; -. DR EnsemblBacteria; BAC44817; BAC44817; BAC44817. DR GeneID; 1041069; -. DR KEGG; mpe:MYPE10320; -. DR PATRIC; 20021252; VBIMycPen56664_1056. DR eggNOG; COG1435; -. DR HOGENOM; HOG000076390; -. DR KO; K00857; -. DR OMA; KVHAICV; -. DR BioCyc; MPEN272633:GJBP-1059-MONOMER; -. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0005524; F:ATP binding; IEA:HAMAP. DR GO; GO:0004797; F:thymidine kinase activity; IEA:HAMAP. DR GO; GO:0008270; F:zinc ion binding; IEA:HAMAP. DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW. DR HAMAP; MF_00124; Thymidine_kinase; 1; -. DR InterPro; IPR001267; Thymidine_kinase. DR InterPro; IPR020633; Thymidine_kinase_CS. DR InterPro; IPR020634; Thymidine_kinase_subgr. DR PANTHER; PTHR11441; PTHR11441; 1. DR Pfam; PF00265; TK; 1. DR PIRSF; PIRSF035805; TK_cell; 1. DR PROSITE; PS00603; TK_CELLULAR_TYPE; 1. PE 3: Inferred from homology; KW ATP-binding; Complete proteome; Cytoplasm; DNA synthesis; Kinase; KW Metal-binding; Nucleotide-binding; Transferase; Zinc. FT CHAIN 1 220 Thymidine kinase. FT /FTId=PRO_0000174998. FT NP_BIND 18 25 ATP (By similarity). FT NP_BIND 93 96 ATP (By similarity). FT ACT_SITE 94 94 Proton acceptor (Potential). FT METAL 150 150 Zinc (By similarity). FT METAL 153 153 Zinc (By similarity). FT METAL 188 188 Zinc (By similarity). FT METAL 191 191 Zinc (By similarity). SQ SEQUENCE 220 AA; 25184 MW; 47CFA4901E74737F CRC64; MKNNAFGKEK GWIELIYGPM FAGKSEELLR KLKRLDYADV IYQVFKPKID TRTKNKIMSR DGRNMDSFEF DNPYEIFDKL LSLEVNPHVV AIDEAQFADE SIVDVCQALA DSGYIVYVSA LDKNFKNEPF MVTAKIACIA EYVEKLSAIC TDCGAPGTAT QRIINDKPSN YDEPVVQIGN YETYTVKCRH HHKIPGKPFP EEIKKFKSDL RNLLKNKENK //