ID Q8DQ50_STRR6 PRELIMINARY; PRT; 247 AA. AC Q8DQ50; DT 01-MAR-2003 (TrEMBLrel. 23, Created) DT 01-MAR-2003 (TrEMBLrel. 23, Last sequence update) DT 01-MAR-2004 (TrEMBLrel. 26, Last annotation update) DE UMP kinase (EC 2.7.4.-). GN Name=pyrH; OrderedLocusNames=spr0845; OS Streptococcus pneumoniae (strain ATCC BAA-255 / R6). OC Bacteria; Firmicutes; Lactobacillales; Streptococcaceae; OC Streptococcus. OX NCBI_TaxID=171101; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=21429245; PubMed=11544234; RX DOI=10.1128/JB.183.19.5709-5717.2001; RA Hoskins J., Alborn W.E. Jr., Arnold J., Blaszczak L.C., Burgett S., RA DeHoff B.S., Estrem S.T., Fritz L., Fu D.-J., Fuller W., Geringer C., RA Gilmour R., Glass J.S., Khoja H., Kraft A.R., Lagace R.E., RA LeBlanc D.J., Lee L.N., Lefkowitz E.J., Lu J., Matsushima P., RA McAhren S.M., McHenney M., McLeaster K., Mundy C.W., Nicas T.I., RA Norris F.H., O'Gara M., Peery R.B., Robertson G.T., Rockey P., RA Sun P.-M., Winkler M.E., Yang Y., Young-Bellido M., Zhao G., RA Zook C.A., Baltz R.H., Jaskunas S.R., Rosteck P.R. Jr., Skatrud P.L., RA Glass J.I.; RT "Genome of the bacterium Streptococcus pneumoniae strain R6."; RL J. Bacteriol. 183:5709-5717(2001). CC -!- FUNCTION: Catalyzes the phosphorylation of UMP to UDP (By CC similarity). CC -!- CATALYTIC ACTIVITY: ATP + UMP = ADP + UDP. CC -!- PATHWAY: Pyrimidine biosynthesis; conversion of UMP to CTP; first CC step. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE008460; AAK99649.1; -. DR PIR; E97977; E97977. DR GO; GO:0016301; F:kinase activity; IEA. DR GO; GO:0016740; F:transferase activity; IEA. DR GO; GO:0008652; P:amino acid biosynthesis; IEA. DR GO; GO:0006221; P:pyrimidine nucleotide biosynthesis; IEA. DR InterPro; IPR001048; Aa_kinase. DR InterPro; IPR011817; PyrH_bact. DR Pfam; PF00696; AA_kinase; 1. DR TIGRFAMs; TIGR02075; pyrH_bact; 1. KW Complete proteome; Kinase; Pyrimidine biosynthesis; Transferase. SQ SEQUENCE 247 AA; 26692 MW; 6DEF633ED4EBFFD4 CRC64; MKMANPKYKR ILIKLSGEAL AGERGVGIDI QTVQTIAKEI QEVHSLGIEI ALVIGGGNLW RGEPAAEAGM DRVQADYTGM LGTVMNALVM ADSLQQVGVD TRVQTAIAMQ QVAEPYVRGR ALRHLEKGRI VIFGAGIGSP YFSTDTTAAL RAAEIEADAI LMAKNGVDGV YNADPKKDKT AVKFEELTHR DVINKGLRIM DSTASTLSMD NDIDLVVFNM NQSGNIKRVV FGENIGTTVS NNIEEKE //