ID PYRH_STRR6 STANDARD; PRT; 247 AA. AC Q8DQ50; DT 16-AUG-2005, integrated into UniProtKB/Swiss-Prot. DT 01-MAR-2003, sequence version 1. DT 07-FEB-2006, entry version 14. DE Uridylate kinase (EC 2.7.4.-) (UK) (Uridine monophosphate kinase) (UMP DE kinase). GN Name=pyrH; OrderedLocusNames=spr0845; OS Streptococcus pneumoniae (strain ATCC BAA-255 / R6). OC Bacteria; Firmicutes; Lactobacillales; Streptococcaceae; OC Streptococcus. OX NCBI_TaxID=171101; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX MEDLINE=21429245; PubMed=11544234; RX DOI=10.1128/JB.183.19.5709-5717.2001; RA Hoskins J., Alborn W.E. Jr., Arnold J., Blaszczak L.C., Burgett S., RA DeHoff B.S., Estrem S.T., Fritz L., Fu D.-J., Fuller W., Geringer C., RA Gilmour R., Glass J.S., Khoja H., Kraft A.R., Lagace R.E., RA LeBlanc D.J., Lee L.N., Lefkowitz E.J., Lu J., Matsushima P., RA McAhren S.M., McHenney M., McLeaster K., Mundy C.W., Nicas T.I., RA Norris F.H., O'Gara M., Peery R.B., Robertson G.T., Rockey P., RA Sun P.-M., Winkler M.E., Yang Y., Young-Bellido M., Zhao G., RA Zook C.A., Baltz R.H., Jaskunas S.R., Rosteck P.R. Jr., Skatrud P.L., RA Glass J.I.; RT "Genome of the bacterium Streptococcus pneumoniae strain R6."; RL J. Bacteriol. 183:5709-5717(2001). CC -!- FUNCTION: Catalyzes the phosphorylation of UMP to UDP (By CC similarity). CC -!- CATALYTIC ACTIVITY: ATP + UMP = ADP + UDP. CC -!- PATHWAY: Pyrimidine biosynthesis; conversion of UMP to CTP; first CC step. CC -!- SIMILARITY: Belongs to the UMP kinase family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE008460; AAK99649.1; -; Genomic_DNA. DR PIR; E97977; E97977. DR SMR; Q8DQ50; 6-241. DR BioCyc; SPNE1313:SPR0845-MONOMER; -. DR HAMAP; MF_01220; -; 1. DR InterPro; IPR001048; Aa_kinase. DR InterPro; IPR011817; PyrH_bact. DR Pfam; PF00696; AA_kinase; 1. DR PIRSF; PIRSF005650; Uridylate_kin; 1. DR TIGRFAMs; TIGR02075; pyrH_bact; 1. KW Complete proteome; Kinase; Pyrimidine biosynthesis; Transferase. FT CHAIN 1 247 Uridylate kinase. FT /FTId=PRO_0000143893. SQ SEQUENCE 247 AA; 26693 MW; 6DEF633ED4EBFFD4 CRC64; MKMANPKYKR ILIKLSGEAL AGERGVGIDI QTVQTIAKEI QEVHSLGIEI ALVIGGGNLW RGEPAAEAGM DRVQADYTGM LGTVMNALVM ADSLQQVGVD TRVQTAIAMQ QVAEPYVRGR ALRHLEKGRI VIFGAGIGSP YFSTDTTAAL RAAEIEADAI LMAKNGVDGV YNADPKKDKT AVKFEELTHR DVINKGLRIM DSTASTLSMD NDIDLVVFNM NQSGNIKRVV FGENIGTTVS NNIEEKE //