ID Q8DQ00_STRR6 Unreviewed; 358 AA. AC Q8DQ00; DT 01-MAR-2003, integrated into UniProtKB/TrEMBL. DT 01-MAR-2003, sequence version 1. DT 21-MAR-2012, entry version 60. DE SubName: Full=Aspartate beta-semialdehyde dehydrogenase; DE EC=1.2.1.11; GN Name=asd; OrderedLocusNames=spr0918; OS Streptococcus pneumoniae (strain ATCC BAA-255 / R6). OC Bacteria; Firmicutes; Lactobacillales; Streptococcaceae; OC Streptococcus. OX NCBI_TaxID=171101; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC BAA-255 / R6; RX MEDLINE=21429245; PubMed=11544234; RX DOI=10.1128/JB.183.19.5709-5717.2001; RA Hoskins J., Alborn W.E. Jr., Arnold J., Blaszczak L.C., Burgett S., RA DeHoff B.S., Estrem S.T., Fritz L., Fu D.-J., Fuller W., Geringer C., RA Gilmour R., Glass J.S., Khoja H., Kraft A.R., Lagace R.E., RA LeBlanc D.J., Lee L.N., Lefkowitz E.J., Lu J., Matsushima P., RA McAhren S.M., McHenney M., McLeaster K., Mundy C.W., Nicas T.I., RA Norris F.H., O'Gara M., Peery R.B., Robertson G.T., Rockey P., RA Sun P.-M., Winkler M.E., Yang Y., Young-Bellido M., Zhao G., RA Zook C.A., Baltz R.H., Jaskunas S.R., Rosteck P.R. Jr., Skatrud P.L., RA Glass J.I.; RT "Genome of the bacterium Streptococcus pneumoniae strain R6."; RL J. Bacteriol. 183:5709-5717(2001). RN [2] RP X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS). RX PubMed=22039970; RA Pavlovsky A.G., Liu X., Faehnle C.R., Potente N., Viola R.E.; RT "Structural characterization of inhibitors with selectivity against RT members of a homologous enzyme family."; RL Chem. Biol. Drug Des. 79:128-136(2012). CC -!- SIMILARITY: Belongs to the aspartate-semialdehyde dehydrogenase CC family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE007317; AAK99722.1; -; Genomic_DNA. DR PIR; F97986; F97986. DR RefSeq; NP_358512.1; NC_003098.1. DR PDB; 3Q1L; X-ray; 2.30 A; A/B/C/D=1-358. DR PDBsum; 3Q1L; -. DR HSSP; P00353; 1BRM. DR ProteinModelPortal; Q8DQ00; -. DR SMR; Q8DQ00; 2-358. DR STRING; Q8DQ00; -. DR EnsemblBacteria; EBSTRT00000015946; EBSTRP00000015342; EBSTRG00000015946. DR GeneID; 933797; -. DR GenomeReviews; AE007317_GR; spr0918. DR KEGG; spr:spr0918; -. DR PATRIC; 19701775; VBIStrPne107296_1005. DR eggNOG; COG0136; -. DR HOGENOM; HBG518238; -. DR KO; K00133; -. DR OMA; LELWLCG; -. DR PhylomeDB; Q8DQ00; -. DR ProtClustDB; PRK14874; -. DR BioCyc; SPNE171101:SPR0918-MONOMER; -. DR GO; GO:0005737; C:cytoplasm; IEA:InterPro. DR GO; GO:0004073; F:aspartate-semialdehyde dehydrogenase activity; IEA:EC. DR GO; GO:0003942; F:N-acetyl-gamma-glutamyl-phosphate reductase activity; IEA:InterPro. DR GO; GO:0051287; F:NAD binding; IEA:InterPro. DR GO; GO:0050661; F:NADP binding; IEA:InterPro. DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro. DR GO; GO:0009097; P:isoleucine biosynthetic process; IEA:InterPro. DR GO; GO:0009089; P:lysine biosynthetic process via diaminopimelate; IEA:InterPro. DR GO; GO:0009086; P:methionine biosynthetic process; IEA:InterPro. DR GO; GO:0009088; P:threonine biosynthetic process; IEA:InterPro. DR HAMAP; MF_02121; ASADH; 1; -. DR InterPro; IPR012080; Asp_semialdehyde_DH. DR InterPro; IPR005986; Asp_semialdehyde_DH_beta. DR InterPro; IPR016040; NAD(P)-bd_dom. DR InterPro; IPR000534; Semialdehyde_DH_NAD-bd. DR InterPro; IPR012280; Semialdhyde_DH_dimer_dom. DR Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1. DR Pfam; PF01118; Semialdhyde_dh; 1. DR Pfam; PF02774; Semialdhyde_dhC; 1. DR PIRSF; PIRSF000148; ASA_dh; 1. DR SMART; SM00859; Semialdhyde_dh; 1. DR TIGRFAMs; TIGR01296; Asd_B; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Oxidoreductase; Reference proteome. FT ACT_SITE 128 128 Acyl-thioester intermediate (By FT similarity). SQ SEQUENCE 358 AA; 38924 MW; 366715956847C96C CRC64; MGYTVAVVGA TGAVGAQMIK MLEESTLPID KIRYLASARS AGKSLKFKDQ DITIEETTET AFEGVDIALF SAGSSTSAKY APYAVKAGVV VVDNTSYFRQ NPDVPLVVPE VNAHALDAHN GIIACPNCST IQMMVALEPV RQKWGLDRII VSTYQAVSGA GMGAILETQR ELREVLNDGV KPCDLHAEIL PSGGDKKHYP IAFNALPQID VFTDNDYTYE EMKMTKETKK IMEDDSIAVS ATCVRIPVLS AHSESVYIET KEVAPIEEVK AAIAAFPGAV LEDDVAHQIY PQAINAVGSR DTFVGRIRKD LDAEKGIHMW VVSDNLLKGA AWNSVQIAET LHERGLVRPT AELKFELK //