ID GSDC3_MOUSE Reviewed; 480 AA. AC Q8CB12; E9QJY6; DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot. DT 27-JUL-2011, sequence version 2. DT 16-OCT-2019, entry version 93. DE RecName: Full=Gasdermin-C3; GN Name=Gsdmc3 {ECO:0000312|MGI:MGI:3580656}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] {ECO:0000312|EMBL:BAC29694.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAC29694.1}; RC TISSUE=Vagina {ECO:0000312|EMBL:BAC29694.1}; RX PubMed=16141072; DOI=10.1126/science.1112014; RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E., RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., RA Hayashizaki Y.; RT "The transcriptional landscape of the mammalian genome."; RL Science 309:1559-1563(2005). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [3] {ECO:0000305} RP IDENTIFICATION. RX PubMed=17350798; DOI=10.1016/j.ygeno.2007.01.003; RA Tamura M., Tanaka S., Fujii T., Aoki A., Komiyama H., Ezawa K., RA Sumiyama K., Sagai T., Shiroishi T.; RT "Members of a novel gene family, Gsdm, are expressed exclusively in RT the epithelium of the skin and gastrointestinal tract in a highly RT tissue-specific manner."; RL Genomics 89:618-629(2007). CC -!- FUNCTION: The N-terminal moiety promotes pyroptosis and exhibits CC bactericidal activity. The physiological relevance of these CC observations is unknown. {ECO:0000250|UniProtKB:Q9BYG8}. CC -!- SUBUNIT: The N-terminal moiety forms homooligomer; disulfide- CC linked. May form an 16-mer complex. Oligomerization occurs in the CC presence of membranes. {ECO:0000250|UniProtKB:P57764}. CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol CC {ECO:0000250|UniProtKB:Q9BYG8}. Cell membrane CC {ECO:0000250|UniProtKB:P57764}. CC -!- DOMAIN: Intramolecular interactions between N- and C-terminal CC domains may be important for autoinhibition in the absence of CC activation signal. The intrinsic pyroptosis-inducing activity is CC carried by the N-terminal domain. {ECO:0000250|UniProtKB:Q5Y4Y6}. CC -!- SIMILARITY: Belongs to the gasdermin family. {ECO:0000255}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK037079; BAC29694.1; -; mRNA. DR EMBL; AC140673; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR CCDS; CCDS37088.1; -. DR RefSeq; NP_899017.2; NM_183194.3. DR RefSeq; XP_006521088.1; XM_006521025.3. DR RefSeq; XP_011243950.1; XM_011245648.2. DR RefSeq; XP_017172127.1; XM_017316638.1. DR RefSeq; XP_017172128.1; XM_017316639.1. DR RefSeq; XP_017172129.1; XM_017316640.1. DR RefSeq; XP_017172130.1; XM_017316641.1. DR RefSeq; XP_017172131.1; XM_017316642.1. DR RefSeq; XP_017172132.1; XM_017316643.1. DR RefSeq; XP_017172133.1; XM_017316644.1. DR RefSeq; XP_017172134.1; XM_017316645.1. DR RefSeq; XP_017172135.1; XM_017316646.1. DR RefSeq; XP_017172136.1; XM_017316647.1. DR RefSeq; XP_017172137.1; XM_017316648.1. DR RefSeq; XP_017172138.1; XM_017316649.1. DR RefSeq; XP_017172139.1; XM_017316650.1. DR RefSeq; XP_017172140.1; XM_017316651.1. DR RefSeq; XP_017172141.1; XM_017316652.1. DR RefSeq; XP_017172142.1; XM_017316653.1. DR iPTMnet; Q8CB12; -. DR PhosphoSitePlus; Q8CB12; -. DR MaxQB; Q8CB12; -. DR PaxDb; Q8CB12; -. DR PRIDE; Q8CB12; -. DR Ensembl; ENSMUST00000089894; ENSMUSP00000087339; ENSMUSG00000055827. DR Ensembl; ENSMUST00000185526; ENSMUSP00000140272; ENSMUSG00000055827. DR Ensembl; ENSMUST00000190682; ENSMUSP00000139472; ENSMUSG00000055827. DR GeneID; 270328; -. DR KEGG; mmu:270328; -. DR UCSC; uc007vza.2; mouse. DR CTD; 270328; -. DR MGI; MGI:3580656; Gsdmc3. DR eggNOG; ENOG410IVCF; Eukaryota. DR eggNOG; ENOG4111AD5; LUCA. DR GeneTree; ENSGT00950000183140; -. DR HOGENOM; HOG000082450; -. DR InParanoid; Q8CB12; -. DR KO; K22143; -. DR OMA; WINDIEP; -. DR OrthoDB; 1067854at2759; -. DR TreeFam; TF331886; -. DR ChiTaRS; Gsdmc3; mouse. DR PRO; PR:Q8CB12; -. DR Proteomes; UP000000589; Chromosome 15. DR Bgee; ENSMUSG00000055827; Expressed in 13 organ(s), highest expression level in crypt of Lieberkuhn of small intestine. DR GO; GO:0005737; C:cytoplasm; ISO:MGI. DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell. DR GO; GO:0005815; C:microtubule organizing center; ISO:MGI. DR GO; GO:0005739; C:mitochondrion; ISO:MGI. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IBA:GO_Central. DR GO; GO:0070273; F:phosphatidylinositol-4-phosphate binding; IBA:GO_Central. DR GO; GO:0001786; F:phosphatidylserine binding; IBA:GO_Central. DR GO; GO:0070269; P:pyroptosis; IBA:GO_Central. DR InterPro; IPR007677; Gasdermin. DR InterPro; IPR040460; Gasdermin_pore. DR InterPro; IPR041263; Gasdermin_PUB. DR PANTHER; PTHR16399; PTHR16399; 1. DR Pfam; PF04598; Gasdermin; 1. DR Pfam; PF17708; Gasdermin_C; 1. PE 2: Evidence at transcript level; KW Cell membrane; Complete proteome; Cytoplasm; Disulfide bond; Membrane; KW Necrosis; Reference proteome. FT CHAIN 1 480 Gasdermin-C3. FT /FTId=PRO_0000347332. FT REGION 1 226 Triggers pyroptosis. FT {ECO:0000250|UniProtKB:Q9BYG8}. FT CONFLICT 383 383 P -> T (in Ref. 1; BAC29694). FT {ECO:0000305}. SQ SEQUENCE 480 AA; 54188 MW; BEA95A9F8FFEEA6A CRC64; MGYSFDRASK DVVKKLQGRD LRPVECLSDA TKFRLFHILQ ETPRSGWETE DIPVGFTLLD LLEPNFPVPE PEVSAPKPFI HVQSTDLEAN LNVADIARGG VGYVGYGGYN IEVQSTSIPN PKLEILQNRK LLDKLPTFMK FCRMERKNLY VVTEAYEVSK DTMLTGLSSV NLLVKGFFKQ LFKVRGKAGR SEKYSIPIPK GSVLAYKKQQ LVIENNTCVI LPSATKKKMT FPGTPKYASA SEPTEIYRTE LQGLWINDIE PIGRIQEPAH LDFKCLQYEV SEQTRLLPEL SKDVQEVVLS SFLSMLYEGD RNVLHDLMKM LELSQLGHMD GPGGKILDEL RKDSSNPCVD LKDLILYLLQ ALMVLSDSQL NLLARSVEMR LLPHQVELVT SILQPNFKYP WNIPFTVQPQ LLAPLQGEGL AITYELLEEC GLKMELNNPR STWDLEAKMP LSALYGSLSF LQQLQKANSS FKPSLRPGYI //