ID Q8C3L6_MOUSE Unreviewed; 513 AA. AC Q8C3L6; DT 01-MAR-2003, integrated into UniProtKB/TrEMBL. DT 01-MAR-2003, sequence version 1. DT 26-FEB-2020, entry version 120. DE RecName: Full=Vacuolar proton pump subunit B {ECO:0000256|RuleBase:RU366021}; DE Short=V-ATPase subunit B {ECO:0000256|RuleBase:RU366021}; DE AltName: Full=Vacuolar proton pump subunit B {ECO:0000256|RuleBase:RU366021}; GN Name=Atp6v1b1 {ECO:0000313|MGI:MGI:103285}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:BAC39470.1}; RN [1] {ECO:0000313|EMBL:BAC39470.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC39470.1}; RC TISSUE=Kidney {ECO:0000313|EMBL:BAC39470.1}; RX PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9; RA Carninci P., Hayashizaki Y.; RT "High-efficiency full-length cDNA cloning."; RL Methods Enzymol. 303:19-44(1999). RN [2] {ECO:0000313|EMBL:BAC39470.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC39470.1}; RC TISSUE=Kidney {ECO:0000313|EMBL:BAC39470.1}; RX PubMed=11042159; DOI=10.1101/gr.145100; RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.; RT "Normalization and subtraction of cap-trapper-selected cDNAs to prepare RT full-length cDNA libraries for rapid discovery of new genes."; RL Genome Res. 10:1617-1630(2000). RN [3] {ECO:0000313|EMBL:BAC39470.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC39470.1}; RC TISSUE=Kidney {ECO:0000313|EMBL:BAC39470.1}; RX PubMed=11076861; DOI=10.1101/gr.152600; RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., RA Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., Yamamoto R., RA Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., RA Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., RA Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., RA Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.; RT "RIKEN integrated sequence analysis (RISA) system--384-format sequencing RT pipeline with 384 multicapillary sequencer."; RL Genome Res. 10:1757-1771(2000). RN [4] {ECO:0000313|EMBL:BAC39470.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC39470.1}; RC TISSUE=Kidney {ECO:0000313|EMBL:BAC39470.1}; RX PubMed=11217851; DOI=10.1038/35055500; RG The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium; RT "Functional annotation of a full-length mouse cDNA collection."; RL Nature 409:685-690(2001). RN [5] {ECO:0000313|EMBL:BAC39470.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC39470.1}; RC TISSUE=Kidney {ECO:0000313|EMBL:BAC39470.1}; RX PubMed=12466851; DOI=10.1038/nature01266; RG The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team; RT "Analysis of the mouse transcriptome based on functional annotation of RT 60,770 full-length cDNAs."; RL Nature 420:563-573(2002). RN [6] {ECO:0000313|EMBL:BAC39470.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC39470.1}; RC TISSUE=Kidney {ECO:0000313|EMBL:BAC39470.1}; RA Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P., RA Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K., RA Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K., RA Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y., RA Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., RA Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R., RA Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K., RA Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T., RA Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S., RA Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M., RA Hayashizaki Y.; RL Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases. RN [7] {ECO:0000313|EMBL:BAC39470.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC39470.1}; RC TISSUE=Kidney {ECO:0000313|EMBL:BAC39470.1}; RG The FANTOM Consortium; RG Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group); RT "The Transcriptional Landscape of the Mammalian Genome."; RL Science 309:1559-1563(2005). RN [8] {ECO:0000313|EMBL:BAC39470.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC39470.1}; RC TISSUE=Kidney {ECO:0000313|EMBL:BAC39470.1}; RX PubMed=16141073; DOI=10.1126/science.1112009; RG RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium; RT "Antisense Transcription in the Mammalian Transcriptome."; RL Science 309:1564-1566(2005). CC -!- FUNCTION: Non-catalytic subunit of the peripheral V1 complex of CC vacuolar ATPase. {ECO:0000256|RuleBase:RU366021}. CC -!- SUBUNIT: V-ATPase is a heteromultimeric enzyme composed of a peripheral CC catalytic V1 complex attached to an integral membrane V0 proton pore CC complex. {ECO:0000256|RuleBase:RU366021}. CC -!- SIMILARITY: Belongs to the ATPase alpha/beta chains family. CC {ECO:0000256|RuleBase:RU366021}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK085549; BAC39470.1; -; mRNA. DR PRIDE; Q8C3L6; -. DR MGI; MGI:103285; Atp6v1b1. DR eggNOG; KOG1351; Eukaryota. DR eggNOG; COG1156; LUCA. DR ChiTaRS; Atp6v1b1; mouse. DR GO; GO:0016324; C:apical plasma membrane; IDA:MGI. DR GO; GO:0016323; C:basolateral plasma membrane; IDA:MGI. DR GO; GO:0098850; C:extrinsic component of synaptic vesicle membrane; ISO:MGI. DR GO; GO:0016020; C:membrane; IDA:MGI. DR GO; GO:0033180; C:proton-transporting V-type ATPase, V1 domain; IEA:InterPro. DR GO; GO:0008021; C:synaptic vesicle; ISO:MGI. DR GO; GO:0016471; C:vacuolar proton-transporting V-type ATPase complex; ISO:MGI. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0044877; F:protein-containing complex binding; ISO:MGI. DR GO; GO:0015078; F:proton transmembrane transporter activity; IMP:MGI. DR GO; GO:0030534; P:adult behavior; IMP:MGI. DR GO; GO:0046034; P:ATP metabolic process; IMP:MGI. DR GO; GO:0055074; P:calcium ion homeostasis; ISO:MGI. DR GO; GO:0055064; P:chloride ion homeostasis; IMP:MGI. DR GO; GO:0007588; P:excretion; ISO:MGI. DR GO; GO:0042048; P:olfactory behavior; IMP:MGI. DR GO; GO:0001503; P:ossification; ISO:MGI. DR GO; GO:0045851; P:pH reduction; ISO:MGI. DR GO; GO:0055075; P:potassium ion homeostasis; IMP:MGI. DR GO; GO:0006693; P:prostaglandin metabolic process; IMP:MGI. DR GO; GO:1902600; P:proton transmembrane transport; ISO:MGI. DR GO; GO:0010468; P:regulation of gene expression; IMP:MGI. DR GO; GO:0006885; P:regulation of pH; IMP:MGI. DR GO; GO:0035812; P:renal sodium excretion; IMP:MGI. DR GO; GO:0003096; P:renal sodium ion transport; IMP:MGI. DR GO; GO:0003091; P:renal water homeostasis; IMP:MGI. DR GO; GO:0007605; P:sensory perception of sound; ISO:MGI. DR HAMAP; MF_00310; ATP_synth_B_arch; 1. DR InterPro; IPR020003; ATPase_a/bsu_AS. DR InterPro; IPR004100; ATPase_F1/V1/A1_a/bsu_N. DR InterPro; IPR000194; ATPase_F1/V1/A1_a/bsu_nucl-bd. DR InterPro; IPR005723; ATPase_V1-cplx_bsu. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR022879; V-ATPase_su_B/beta. DR PANTHER; PTHR43389; PTHR43389; 1. DR Pfam; PF00006; ATP-synt_ab; 1. DR Pfam; PF02874; ATP-synt_ab_N; 1. DR PIRSF; PIRSF039114; V-ATPsynth_beta/V-ATPase_B; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR TIGRFAMs; TIGR01040; V-ATPase_V1_B; 1. DR PROSITE; PS00152; ATPASE_ALPHA_BETA; 1. PE 2: Evidence at transcript level; KW Hydrogen ion transport {ECO:0000256|RuleBase:RU366021}; KW Ion transport {ECO:0000256|RuleBase:RU366021}; KW Transport {ECO:0000256|RuleBase:RU366021}. FT DOMAIN 44..110 FT /note="ATP-synt_ab_N" FT /evidence="ECO:0000259|Pfam:PF02874" FT DOMAIN 167..393 FT /note="ATP-synt_ab" FT /evidence="ECO:0000259|Pfam:PF00006" FT REGION 1..21 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 513 AA; 56833 MW; B2F0AFE362ECB518 CRC64; MATTVDSRSS GFTGNSCDPG TAQEHVQAVT RNYITHPRVT YRTVCSVNGP LVVLDQVKFA QYAEIVNFTL PDVTQRSGQV LEVAGTKAIV QVFEGTSGID SQKTTCEFTG DILRTPVSED MLGRIFNGSG KPIDKGPAVM AEEFLDINGQ PINPHDRIYP EEMIQTGISP IDVMNSIARG QKIPIFSAAG LPHNEIAAQI CRQAGLVKKS KAVLDYHEDN FAIVFAAMGV NMETARFFKS DFEQNGTMGN VCLFLNLAND PTIERIITPR LALTTAEFLA YQCEKHVLVI LTDMSSYAEA LREVSAAREE VPGRRGFPGY MYTDLATIYE RAGRVEGRGG SITQIPILTM PNDDITHPIP DLTGFITEGQ IYVDRQLHNR QVYPPINVLP SLSRLMKSAI GEGMTRKDHG DVSNQLYACY AIGKDVQAMK AVVGEEALTS EDLLYLEFLQ KFEKNFITQG PYENRTVFES LDLGWKLLRI FPKEMLKRIP QSMTDEFYSR QGAQQDPASD TAL //