ID Q8BUX6_MOUSE Unreviewed; 180 AA. AC Q8BUX6; DT 01-MAR-2003, integrated into UniProtKB/TrEMBL. DT 01-MAR-2003, sequence version 1. DT 14-DEC-2022, entry version 105. DE RecName: Full=AdenylateSensor domain-containing protein {ECO:0000259|Pfam:PF16579}; DE Flags: Fragment; GN Name=Prkaa1 {ECO:0000313|MGI:MGI:2145955}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:BAC38355.1}; RN [1] {ECO:0000313|EMBL:BAC38355.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC38355.1}; RC TISSUE=Head {ECO:0000313|EMBL:BAC38355.1}; RX PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9; RA Carninci P., Hayashizaki Y.; RT "High-efficiency full-length cDNA cloning."; RL Methods Enzymol. 303:19-44(1999). RN [2] {ECO:0000313|EMBL:BAC38355.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC38355.1}; RC TISSUE=Head {ECO:0000313|EMBL:BAC38355.1}; RX PubMed=11042159; DOI=10.1101/gr.145100; RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.; RT "Normalization and subtraction of cap-trapper-selected cDNAs to prepare RT full-length cDNA libraries for rapid discovery of new genes."; RL Genome Res. 10:1617-1630(2000). RN [3] {ECO:0000313|EMBL:BAC38355.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC38355.1}; RC TISSUE=Head {ECO:0000313|EMBL:BAC38355.1}; RX PubMed=11076861; DOI=10.1101/gr.152600; RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., RA Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., Yamamoto R., RA Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., RA Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., RA Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., RA Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.; RT "RIKEN integrated sequence analysis (RISA) system--384-format sequencing RT pipeline with 384 multicapillary sequencer."; RL Genome Res. 10:1757-1771(2000). RN [4] {ECO:0000313|EMBL:BAC38355.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC38355.1}; RC TISSUE=Head {ECO:0000313|EMBL:BAC38355.1}; RX PubMed=11217851; DOI=10.1038/35055500; RG The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium; RT "Functional annotation of a full-length mouse cDNA collection."; RL Nature 409:685-690(2001). RN [5] {ECO:0000313|EMBL:BAC38355.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC38355.1}; RC TISSUE=Head {ECO:0000313|EMBL:BAC38355.1}; RX PubMed=12466851; DOI=10.1038/nature01266; RG The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team; RT "Analysis of the mouse transcriptome based on functional annotation of RT 60,770 full-length cDNAs."; RL Nature 420:563-573(2002). RN [6] {ECO:0000313|EMBL:BAC38355.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC38355.1}; RC TISSUE=Head {ECO:0000313|EMBL:BAC38355.1}; RA Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P., RA Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K., RA Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K., RA Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y., RA Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., RA Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R., RA Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K., RA Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T., RA Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S., RA Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M., RA Hayashizaki Y.; RL Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases. RN [7] {ECO:0000313|EMBL:BAC38355.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC38355.1}; RC TISSUE=Head {ECO:0000313|EMBL:BAC38355.1}; RG The FANTOM Consortium; RG Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group); RT "The Transcriptional Landscape of the Mammalian Genome."; RL Science 309:1559-1563(2005). RN [8] {ECO:0000313|EMBL:BAC38355.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC38355.1}; RC TISSUE=Head {ECO:0000313|EMBL:BAC38355.1}; RX PubMed=16141073; DOI=10.1126/science.1112009; RG RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium; RT "Antisense Transcription in the Mammalian Transcriptome."; RL Science 309:1564-1566(2005). CC -!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr CC protein kinase family. SNF1 subfamily. {ECO:0000256|ARBA:ARBA00006234}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK081874; BAC38355.1; -; mRNA. DR RefSeq; NP_001013385.3; NM_001013367.3. DR AlphaFoldDB; Q8BUX6; -. DR PeptideAtlas; Q8BUX6; -. DR DNASU; 105787; -. DR GeneID; 105787; -. DR KEGG; mmu:105787; -. DR AGR; MGI:2145955; -. DR CTD; 5562; -. DR MGI; MGI:2145955; Prkaa1. DR OrthoDB; 1127668at2759; -. DR BioGRID-ORCS; 105787; 9 hits in 82 CRISPR screens. DR ChiTaRS; Prkaa1; mouse. DR Genevisible; Q8BUX6; MM. DR GO; GO:0004679; F:AMP-activated protein kinase activity; IEA:InterPro. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR CDD; cd12199; AMPKA1_C; 1. DR InterPro; IPR032270; AMPK_C. DR InterPro; IPR039137; AMPKA1_C. DR InterPro; IPR028375; KA1/Ssp2_C. DR Pfam; PF16579; AdenylateSensor; 1. DR SUPFAM; SSF103243; KA1-like; 1. PE 2: Evidence at transcript level; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840}; KW Kinase {ECO:0000256|ARBA:ARBA00022527}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}; KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527}; KW Transferase {ECO:0000256|ARBA:ARBA00022527}. FT DOMAIN 27..103 FT /note="AdenylateSensor" FT /evidence="ECO:0000259|Pfam:PF16579" FT REGION 106..157 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 106..152 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:BAC38355.1" SQ SEQUENCE 180 AA; 20333 MW; F75293A639D06C76 CRC64; AETPRARHTL DELNPQKSKH QGVRKAKWHL GIRSQSRPND IMAEVCRAIK QLDYEWKVVN PYYLRVRRKN PVTSTFSKMS LQLYQVDSRT YLLDFRSIDD EITEAKSGTA TPQRSGSISN YRSCQRSDSD AEAQGKPSDV SLTSSVTSLD SSPVDVAPRP GSHTIEFFEM CANLIKILAQ //