ID EXOS6_MOUSE Reviewed; 273 AA. AC Q8BTW3; Q9CSR7; DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot. DT 01-MAR-2003, sequence version 1. DT 30-NOV-2010, entry version 59. DE RecName: Full=Exosome complex exonuclease MTR3; DE EC=3.1.13.-; DE AltName: Full=Exosome component 6; DE AltName: Full=mRNA transport regulator 3 homolog; GN Name=Exosc6; Synonyms=Mtr3; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6J, and NOD; TISSUE=Thymus; RX PubMed=16141072; DOI=10.1126/science.1112014; RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E., RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., RA Hayashizaki Y.; RT "The transcriptional landscape of the mammalian genome."; RL Science 309:1559-1563(2005). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Component of the exosome 3'->5' exoribonuclease complex, CC a complex that degrades inherently unstable mRNAs containing AU- CC rich elements (AREs) within their 3'-untranslated regions. CC Required for the 3'-processing of the 7S pre-RNA to the mature CC 5.8S rRNA. Probably has a 3'-5' exonuclease activity (By CC similarity). CC -!- SUBUNIT: Component of the exosome multienzyme ribonuclease complex CC composed of at least 11 proteins: EXOSC1/CSL4, EXOSC2/RRP4, CC EXOSC3/RRP40, EXOSC4/RRP41, EXOSC5/RRP46, EXOSC6/MTR3, CC EXOSC7/RRP42, EXOSC8/RRP43, EXOSC9/Scl-75, DIS3/RRP44, and CC EXOSC10/Scl-100 (only in the nuclear complex). In the exosome CC multienzyme ribonuclease complex, interacts directly with EXOSC1, CC EXOSC7 and EXOSC8 (By similarity). CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus, CC nucleolus (By similarity). CC -!- SIMILARITY: Belongs to the RNase PH family. CC -!- SEQUENCE CAUTION: CC Sequence=BAB28033.1; Type=Frameshift; Positions=79; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK012102; BAB28033.1; ALT_FRAME; mRNA. DR EMBL; AK088532; BAC40407.1; -; mRNA. DR EMBL; BC116985; AAI16986.1; -; mRNA. DR EMBL; BC119082; AAI19083.1; -; mRNA. DR IPI; IPI00466593; -. DR RefSeq; NP_082550.1; NM_028274.3. DR UniGene; Mm.24174; -. DR UniGene; Mm.334810; -. DR HSSP; Q9UXC2; 2C39. DR ProteinModelPortal; Q8BTW3; -. DR SMR; Q8BTW3; 29-261. DR PRIDE; Q8BTW3; -. DR Ensembl; ENSMUST00000116163; ENSMUSP00000111863; ENSMUSG00000080049. DR GeneID; 72544; -. DR KEGG; mmu:72544; -. DR UCSC; uc009nlp.1; mouse. DR CTD; 72544; -. DR MGI; MGI:1919794; Exosc6. DR HOGENOM; HBG737187; -. DR HOVERGEN; HBG057826; -. DR InParanoid; Q8BTW3; -. DR OrthoDB; EOG9MSGHK; -. DR NextBio; 336459; -. DR ArrayExpress; Q8BTW3; -. DR CleanEx; MM_EXOSC6; -. DR Genevestigator; Q8BTW3; -. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW. DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell. DR GO; GO:0000175; F:3'-5'-exoribonuclease activity; IEA:InterPro. DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW. DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW. DR InterPro; IPR001247; ExoRNase_PH_dom1. DR InterPro; IPR015847; ExoRNase_PH_dom2. DR InterPro; IPR020568; Ribosomal_S5_D2-typ_fold. DR Pfam; PF01138; RNase_PH; 1. DR SUPFAM; SSF55666; 3_ExoRNase; 1. DR SUPFAM; SSF54211; Ribosomal_S5_D2-typ_fold; 1. PE 2: Evidence at transcript level; KW Cytoplasm; Exonuclease; Exosome; Hydrolase; Nuclease; Nucleus; KW RNA-binding; rRNA processing. FT CHAIN 1 273 Exosome complex exonuclease MTR3. FT /FTId=PRO_0000287479. SQ SEQUENCE 273 AA; 28370 MW; 6AC4310F46742B10 CRC64; MPGDHRRIRG PEESQPPQLY AAEDDETPAA RDPTRLRPVY ARAGLLSQAK GSAYLEAGGT KVLCAVSGPR QAEGGERGSG PAGAGGEAPA ALRGRLLCDF RRAPFSGRRR RAPQGGGGED RELGLALQEA LEPAVRLGRY PRAQLEVSAL LLEDGGCALA AALTAAALAL ADAGVEMYDL VVGCGLSLTP GPSPTWLLDP TRLEEEHSAA GLTVALMPVL NQVAGLLGSG EGGQTESWTD AVRLGLEGCQ RLYPVLQQCL VRAARRRGAA APP //