ID   EXOS6_MOUSE             Reviewed;         273 AA.
AC   Q8BTW3; Q9CSR7;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   05-OCT-2010, entry version 58.
DE   RecName: Full=Exosome complex exonuclease MTR3;
DE            EC=3.1.13.-;
DE   AltName: Full=Exosome component 6;
DE   AltName: Full=mRNA transport regulator 3 homolog;
GN   Name=Exosc6; Synonyms=Mtr3;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J, and NOD; TISSUE=Thymus;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Component of the exosome 3'->5' exoribonuclease complex,
CC       a complex that degrades inherently unstable mRNAs containing AU-
CC       rich elements (AREs) within their 3'-untranslated regions.
CC       Required for the 3'-processing of the 7S pre-RNA to the mature
CC       5.8S rRNA. Probably has a 3'-5' exonuclease activity (By
CC       similarity).
CC   -!- SUBUNIT: Component of the exosome multienzyme ribonuclease complex
CC       composed of at least 11 proteins: EXOSC1/CSL4, EXOSC2/RRP4,
CC       EXOSC3/RRP40, EXOSC4/RRP41, EXOSC5/RRP46, EXOSC6/MTR3,
CC       EXOSC7/RRP42, EXOSC8/RRP43, EXOSC9/Scl-75, DIS3/RRP44, and
CC       EXOSC10/Scl-100 (only in the nuclear complex). In the exosome
CC       multienzyme ribonuclease complex, interacts directly with EXOSC1,
CC       EXOSC7 and EXOSC8 (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus,
CC       nucleolus (By similarity).
CC   -!- SIMILARITY: Belongs to the RNase PH family.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB28033.1; Type=Frameshift; Positions=79;
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DR   EMBL; AK012102; BAB28033.1; ALT_FRAME; mRNA.
DR   EMBL; AK088532; BAC40407.1; -; mRNA.
DR   EMBL; BC116985; AAI16986.1; -; mRNA.
DR   EMBL; BC119082; AAI19083.1; -; mRNA.
DR   IPI; IPI00466593; -.
DR   RefSeq; NP_082550.1; -.
DR   UniGene; Mm.24174; -.
DR   UniGene; Mm.334810; -.
DR   HSSP; Q9UXC2; 2C39.
DR   ProteinModelPortal; Q8BTW3; -.
DR   SMR; Q8BTW3; 29-261.
DR   PRIDE; Q8BTW3; -.
DR   Ensembl; ENSMUST00000116163; ENSMUSP00000111863; ENSMUSG00000080049.
DR   GeneID; 72544; -.
DR   KEGG; mmu:72544; -.
DR   UCSC; uc009nlp.1; mouse.
DR   CTD; 72544; -.
DR   MGI; MGI:1919794; Exosc6.
DR   HOGENOM; HBG737187; -.
DR   HOVERGEN; HBG057826; -.
DR   InParanoid; Q8BTW3; -.
DR   OrthoDB; EOG9MSGHK; -.
DR   NextBio; 336459; -.
DR   ArrayExpress; Q8BTW3; -.
DR   CleanEx; MM_EXOSC6; -.
DR   Genevestigator; Q8BTW3; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000175; F:3'-5'-exoribonuclease activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR001247; ExoRNase_PH_dom1.
DR   InterPro; IPR015847; ExoRNase_PH_dom2.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   Pfam; PF01138; RNase_PH; 1.
DR   SUPFAM; SSF55666; 3_ExoRNase; 1.
DR   SUPFAM; SSF54211; Ribosomal_S5_D2-typ_fold; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Exonuclease; Exosome; Hydrolase; Nuclease; Nucleus;
KW   RNA-binding; rRNA processing.
FT   CHAIN         1    273       Exosome complex exonuclease MTR3.
FT                                /FTId=PRO_0000287479.
SQ   SEQUENCE   273 AA;  28370 MW;  6AC4310F46742B10 CRC64;
     MPGDHRRIRG PEESQPPQLY AAEDDETPAA RDPTRLRPVY ARAGLLSQAK GSAYLEAGGT
     KVLCAVSGPR QAEGGERGSG PAGAGGEAPA ALRGRLLCDF RRAPFSGRRR RAPQGGGGED
     RELGLALQEA LEPAVRLGRY PRAQLEVSAL LLEDGGCALA AALTAAALAL ADAGVEMYDL
     VVGCGLSLTP GPSPTWLLDP TRLEEEHSAA GLTVALMPVL NQVAGLLGSG EGGQTESWTD
     AVRLGLEGCQ RLYPVLQQCL VRAARRRGAA APP
//