ID Q8BMG0_MOUSE Unreviewed; 643 AA. AC Q8BMG0; DT 01-MAR-2003, integrated into UniProtKB/TrEMBL. DT 01-MAR-2003, sequence version 1. DT 13-SEP-2023, entry version 151. DE SubName: Full=Iduronidase, alpha-L {ECO:0000313|Ensembl:ENSMUSP00000071577.7}; GN Name=Idua {ECO:0000313|Ensembl:ENSMUSP00000071577.7, GN ECO:0000313|MGI:MGI:96418}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:BAC27393.1}; RN [1] {ECO:0000313|EMBL:BAC27393.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC27393.1}; RC TISSUE=Testis {ECO:0000313|EMBL:BAC27393.1}; RX PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9; RA Carninci P., Hayashizaki Y.; RT "High-efficiency full-length cDNA cloning."; RL Methods Enzymol. 303:19-44(1999). RN [2] {ECO:0000313|EMBL:BAC27393.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC27393.1}; RC TISSUE=Testis {ECO:0000313|EMBL:BAC27393.1}; RX PubMed=11042159; DOI=10.1101/gr.145100; RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.; RT "Normalization and subtraction of cap-trapper-selected cDNAs to prepare RT full-length cDNA libraries for rapid discovery of new genes."; RL Genome Res. 10:1617-1630(2000). RN [3] {ECO:0000313|EMBL:BAC27393.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC27393.1}; RC TISSUE=Testis {ECO:0000313|EMBL:BAC27393.1}; RX PubMed=11076861; DOI=10.1101/gr.152600; RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., RA Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., Yamamoto R., RA Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., RA Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., RA Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., RA Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.; RT "RIKEN integrated sequence analysis (RISA) system--384-format sequencing RT pipeline with 384 multicapillary sequencer."; RL Genome Res. 10:1757-1771(2000). RN [4] {ECO:0000313|EMBL:BAC27393.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC27393.1}; RC TISSUE=Testis {ECO:0000313|EMBL:BAC27393.1}; RX PubMed=11217851; DOI=10.1038/35055500; RG The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium; RT "Functional annotation of a full-length mouse cDNA collection."; RL Nature 409:685-690(2001). RN [5] {ECO:0000313|EMBL:BAC27393.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC27393.1}; RC TISSUE=Testis {ECO:0000313|EMBL:BAC27393.1}; RA Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P., RA Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K., RA Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K., RA Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y., RA Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., RA Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R., RA Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K., RA Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T., RA Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S., RA Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M., RA Hayashizaki Y.; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. RN [6] {ECO:0000313|EMBL:BAC27393.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC27393.1}; RC TISSUE=Testis {ECO:0000313|EMBL:BAC27393.1}; RX PubMed=12466851; DOI=10.1038/nature01266; RG The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team; RT "Analysis of the mouse transcriptome based on functional annotation of RT 60,770 full-length cDNAs."; RL Nature 420:563-573(2002). RN [7] {ECO:0000313|EMBL:BAC27393.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC27393.1}; RC TISSUE=Testis {ECO:0000313|EMBL:BAC27393.1}; RG The FANTOM Consortium; RG Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group); RT "The Transcriptional Landscape of the Mammalian Genome."; RL Science 309:1559-1563(2005). RN [8] {ECO:0000313|EMBL:BAC27393.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC27393.1}; RC TISSUE=Testis {ECO:0000313|EMBL:BAC27393.1}; RX PubMed=16141073; DOI=10.1126/science.1112009; RG RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium; RT "Antisense Transcription in the Mammalian Transcriptome."; RL Science 309:1564-1566(2005). RN [9] {ECO:0000313|Ensembl:ENSMUSP00000071577.7, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000071577.7, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [10] {ECO:0000313|Ensembl:ENSMUSP00000071577.7} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000071577.7}; RG Ensembl; RL Submitted (MAY-2023) to UniProtKB. CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 39 family. CC {ECO:0000256|ARBA:ARBA00008875}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK031414; BAC27393.1; -; mRNA. DR RefSeq; NP_032351.2; NM_008325.4. DR RefSeq; NP_766585.1; NM_172997.1. DR CAZy; GH39; Glycoside Hydrolase Family 39. DR ProteomicsDB; 343428; -. DR Antibodypedia; 43016; 246 antibodies from 26 providers. DR DNASU; 15932; -. DR Ensembl; ENSMUST00000071650.13; ENSMUSP00000071577.7; ENSMUSG00000033540.19. DR Ensembl; ENSMUST00000112563.9; ENSMUSP00000108182.3; ENSMUSG00000033540.19. DR GeneID; 15932; -. DR KEGG; mmu:15932; -. DR UCSC; uc008yov.3; mouse. DR AGR; MGI:96418; -. DR CTD; 3425; -. DR MGI; MGI:96418; Idua. DR VEuPathDB; HostDB:ENSMUSG00000033540; -. DR GeneTree; ENSGT00390000015494; -. DR HOGENOM; CLU_028716_0_0_1; -. DR OMA; AHYTSGD; -. DR OrthoDB; 4589at2759; -. DR TreeFam; TF323228; -. DR BioGRID-ORCS; 15932; 0 hits in 79 CRISPR screens. DR ChiTaRS; Idua; mouse. DR Proteomes; UP000000589; Chromosome 5. DR Bgee; ENSMUSG00000033540; Expressed in heart right ventricle and 259 other tissues. DR GO; GO:0003940; F:L-iduronidase activity; IEA:Ensembl. DR GO; GO:0005102; F:signaling receptor binding; IEA:Ensembl. DR GO; GO:0030209; P:dermatan sulfate catabolic process; IEA:Ensembl. DR GO; GO:0030211; P:heparin catabolic process; IEA:Ensembl. DR Gene3D; 3.20.20.80; Glycosidases; 1. DR Gene3D; 2.60.40.10; Immunoglobulins; 1. DR InterPro; IPR000514; Glyco_hydro_39. DR InterPro; IPR017853; Glycoside_hydrolase_SF. DR InterPro; IPR013783; Ig-like_fold. DR PANTHER; PTHR12631; ALPHA-L-IDURONIDASE; 1. DR PANTHER; PTHR12631:SF8; ALPHA-L-IDURONIDASE; 1. DR Pfam; PF01229; Glyco_hydro_39; 1. DR PRINTS; PR00745; GLHYDRLASE39. DR SUPFAM; SSF51445; (Trans)glycosidases; 1. DR SUPFAM; SSF51011; Glycosyl hydrolase domain; 1. DR PROSITE; PS01027; GLYCOSYL_HYDROL_F39; 1. PE 1: Evidence at protein level; KW Glycosidase {ECO:0000256|ARBA:ARBA00023295}; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}; KW Proteomics identification {ECO:0007829|EPD:Q8BMG0, KW ECO:0007829|MaxQB:Q8BMG0}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1..25 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 26..643 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5015099016" FT ACT_SITE 181 FT /note="Proton donor" FT /evidence="ECO:0000256|PIRSR:PIRSR600514-1" SQ SEQUENCE 643 AA; 72235 MW; DAC2F2D04F5F10DF CRC64; MRPPRPSSAM LTFFAAFLAA PLALAESPYL VRVDAARPLR PLLPFWRSTG FCPPLPHDQA DQYDLSWDQQ LNLAYIGAVP HSGIEQVRIH WLLDLITARK SPGQGLMYNF THLDAFLDLL MENQLLPGFE LMGSPSGYFT DFDDKQQVFE WKDLVSLLAR RYIGRYGLTH VSKWNFETWN EPDHHDFDNV SMTTQGFLNY YDACSEGLRI ASPTLKLGGP GDSFHPLPRS PMCWSLLGHC ANGTNFFTGE VGVRLDYISL HKKGAGSSIA ILEQEMAVVE QVQQLFPEFK DTPIYNDEAD PLVGWSLPQP WRADVTYAAL VVKVIAQHQN LLFANSSSSM RYVLLSNDNA FLSYHPYPFS QRTLTARFQV NNTHPPHVQL LRKPVLTVMG LMALLDGEQL WAEVSKAGAV LDSNHTVGVL ASTHHPEGSA AAWSTTVLIY TSDDTHAHPN HSIPVTLRLR GVPPGLDLVY IVLYLDNQLS SPYSAWQHMG QPVFPSAEQF RRMRMVEDPV AEAPRPFPAR GRLTLHRKLP VPSLLLVHVC TRPLKPPGQV SRLRALPLTH GQLILVWSDE RVGSKCLWTY EIQFSQKGEE YAPINRRPST FNLFVFSPDT AVVSGSYRVR ALDYWARPGP FSDPVTYLDV PAS //