ID U84B_MOUSE STANDARD; PRT; 699 AA. AC Q8BJS4; DT 15-MAR-2004 (Rel. 43, Created) DT 15-MAR-2004 (Rel. 43, Last sequence update) DT 15-MAR-2004 (Rel. 43, Last annotation update) DE Sad1/unc-84-like protein 2. GN UNC84B OR SUN2. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RA Oshima A., Takahashi-Fujii A., Tanase T., Imose N., Takeuchi K., RA Arita M., Musashino K., Yuuki H., Hara H., Sugiyama T., Irie R., RA Otsuki T., Sato H., Ota T., Wakamatsu A., Ishii S., Yamamoto J., RA Isono Y., Kawai-Hio Y., Saito K., Nishikawa T., Kimura K., RA Yamashita H., Matsuo K., Nakamura Y., Sekine M., Kikuchi H., Kanda K., RA Wagatsuma M., Murakawa K., Kanehori K., Sugiyama A., Kawakami B., RA Suzuki Y., Sugano S., Nagahari K., Masuho Y., Nagai K., Isogai T.; RT "NEDO cDNA sequencing project."; RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases. RN [2] RP SEQUENCE OF 647-699 FROM N.A. RC STRAIN=C57BL/6J; TISSUE=Aorta, and Vein; RX MEDLINE=22354683; PubMed=12466851; RA Okazaki Y., Furuno M., Kasukawa T., Adachi J., Bono H., Kondo S., RA Nikaido I., Osato N., Saito R., Suzuki H., Yamanaka I., Kiyosawa H., RA Yagi K., Tomaru Y., Hasegawa Y., Nogami A., Schonbach C., Gojobori T., RA Baldarelli R., Hill D.P., Bult C., Hume D.A., Quackenbush J., RA Schriml L.M., Kanapin A., Matsuda H., Batalov S., Beisel K.W., RA Blake J.A., Bradt D., Brusic V., Chothia C., Corbani L.E., Cousins S., RA Dalla E., Dragani T.A., Fletcher C.F., Forrest A., Frazer K.S., RA Gaasterland T., Gariboldi M., Gissi C., Godzik A., Gough J., RA Grimmond S., Gustincich S., Hirokawa N., Jackson I.J., Jarvis E.D., RA Kanai A., Kawaji H., Kawasawa Y., Kedzierski R.M., King B.L., RA Konagaya A., Kurochkin I.V., Lee Y., Lenhard B., Lyons P.A., RA Maglott D.R., Maltais L., Marchionni L., McKenzie L., Miki H., RA Nagashima T., Numata K., Okido T., Pavan W.J., Pertea G., Pesole G., RA Petrovsky N., Pillai R., Pontius J.U., Qi D., Ramachandran S., RA Ravasi T., Reed J.C., Reed D.J., Reid J., Ring B.Z., Ringwald M., RA Sandelin A., Schneider C., Semple C.A., Setou M., Shimada K., RA Sultana R., Takenaka Y., Taylor M.S., Teasdale R.D., Tomita M., RA Verardo R., Wagner L., Wahlestedt C., Wang Y., Watanabe Y., Wells C., RA Wilming L.G., Wynshaw-Boris A., Yanagisawa M., Yang I., Yang L., RA Yuan Z., Zavolan M., Zhu Y., Zimmer A., Carninci P., Hayatsu N., RA Hirozane-Kishikawa T., Konno H., Nakamura M., Sakazume N., Sato K., RA Shiraki T., Waki K., Kawai J., Aizawa K., Arakawa T., Fukuda S., RA Hara A., Hashizume W., Imotani K., Ishii Y., Itoh M., Kagawa I., RA Miyazaki A., Sakai K., Sasaki D., Shibata K., Shinagawa A., RA Yasunishi A., Yoshino M., Waterston R., Lander E.S., Rogers J., RA Birney E., Hayashizaki Y.; RT "Analysis of the mouse transcriptome based on functional annotation of RT 60,770 full-length cDNAs."; RL Nature 420:563-573(2002). RN [3] RP TISSUE SPECIFICITY. RX PubMed=12393179; RA Sun G., Yuen Chan S., Yuan Y., Wang Chan K., Qiu G., Sun K., RA Ping Leung M.; RT "Isolation of differentially expressed genes in human heart tissues."; RL Biochim. Biophys. Acta 1588:241-246(2002). CC -!- SUBUNIT: Interacts with RAB5A (By similarity). CC -!- SUBCELLULAR LOCATION: Nuclear transmembrane protein. May also CC localizes to endosomes (By similarity). CC -!- TISSUE SPECIFICITY: Highly expressed in heart, CC placenta and muscle. CC -!- DOMAIN: The Unc84 domain may play a role in the nuclear anchoring CC and/or migration. CC -!- SIMILARITY: Contains 1 Unc84 (SUN) domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK128958; BAC87662.1; -. DR EMBL; AK080116; BAC37829.1; -. DR MGD; MGI:2146038; AI551766. KW Transmembrane; Nuclear protein; Coiled coil. FT TRANSMEM 195 215 Potential. FT DOMAIN 259 275 Coiled coil (Potential). FT DOMAIN 334 420 Coiled coil (Potential). FT DOMAIN 458 487 Coiled coil (Potential). FT DOMAIN 583 699 UNC84. SQ SEQUENCE 699 AA; 78194 MW; 991F96BE094BAFA8 CRC64; MSRRSQRLTR YSQDDNDGGS SSSGASSVAG SQGTVFKDSP LRTLKRKSSN MKHLSPAPQL GPSSDSHTSY YSESVVRESY IGSPRAVSLA RSALLDDHLH SEPYWSGDLR GRRRRGTGGS ESSKANGLTA ESKASEDFFG SSSGYSSEDD LAGRLFGLLY WWIGTTWYRL TTAASLLDVF VLTRSRHFSL NLKSFLWFLL LLLLLTGLTY GAWHFYPLGL QTLQPAVVSW WAAKESRKQP EVWESRDASQ HFQAEQRVLS RVHSLERRLE ALAADFSSNW QKEAIRLERL ELRQGAAGHG GGSSLSHEDA LSLLEGLVSR REATLKEDLR RDTVAHIQEE LATLRAEHHQ DSEDLFKKIV QASQESEARV QQLKTEWKSV TQEAFQESSV KELGRLEAQL ASLRQELAAL TLKQNSVAYE VGLLPQKIQA ARADVESQFP DWIRQFLLGD RGARSGLLQR DEMHAQLQEL ENKILTKMAE MQGKSAREAA ASLGQILQKE GIVGVTEEQV HRIVKQALQR YSEDRIGMVD YALESGGASV ISTRCSETYE TKTALLSLFG IPLWYHSQSP RVILQPDVHP GNCWAFQGPQ GFAVVRLSAR IRPTAVTLEH VPKALSPNST ISSAPKDFAI FGFDEDLQQE GTLLGTFAYD QDGEPIQTFY FQASKMATYQ VVELRILTNW GHPEYTCIYR FRVHGEPAH //