ID UN84B_MOUSE STANDARD; PRT; 699 AA. AC Q8BJS4; DT 02-FEB-2004, integrated into UniProtKB/Swiss-Prot. DT 02-FEB-2004, sequence version 2. DT 16-MAY-2006, entry version 24. DE Sad1/unc-84-like protein 2. GN Name=Unc84b; Synonyms=Sun2; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RA Oshima A., Takahashi-Fujii A., Tanase T., Imose N., Takeuchi K., RA Arita M., Musashino K., Yuuki H., Hara H., Sugiyama T., Irie R., RA Otsuki T., Sato H., Ota T., Wakamatsu A., Ishii S., Yamamoto J., RA Isono Y., Kawai-Hio Y., Saito K., Nishikawa T., Kimura K., RA Yamashita H., Matsuo K., Nakamura Y., Sekine M., Kikuchi H., Kanda K., RA Wagatsuma M., Murakawa K., Kanehori K., Sugiyama A., Kawakami B., RA Suzuki Y., Sugano S., Nagahari K., Masuho Y., Nagai K., Isogai T.; RT "NEDO cDNA sequencing project."; RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 647-699. RC STRAIN=C57BL/6J; TISSUE=Aorta, and Vein; RX PubMed=16141072; DOI=10.1126/science.1112014; RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E., RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., RA Hayashizaki Y.; RT "The transcriptional landscape of the mammalian genome."; RL Science 309:1559-1563(2005). RN [3] RP TISSUE SPECIFICITY. RX PubMed=12393179; DOI=10.1016/S0925-4439(02)00171-0; RA Sun G., Yuen Chan S., Yuan Y., Wang Chan K., Qiu G., Sun K., RA Ping Leung M.; RT "Isolation of differentially expressed genes in human heart tissues."; RL Biochim. Biophys. Acta 1588:241-246(2002). CC -!- SUBUNIT: Interacts with RAB5A (By similarity). CC -!- SUBCELLULAR LOCATION: Nucleus; nuclear membrane; single-pass CC membrane protein (By similarity). Endosome; endosomal membrane; CC single-pass membrane protein (By similarity). CC -!- TISSUE SPECIFICITY: Highly expressed in heart, placenta and CC muscle. CC -!- DOMAIN: The Unc84 domain may play a role in the nuclear anchoring CC and/or migration. CC -!- SIMILARITY: Contains 1 Unc84 (SUN) domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK128958; BAC87662.1; -; mRNA. DR EMBL; AK080116; BAC37829.1; -; mRNA. DR UniGene; Mm.202715; -. DR Ensembl; ENSMUSG00000042524; Mus musculus. DR MGI; MGI:2443011; Unc84b. DR InterPro; IPR012919; Sad1_UNC_C. DR Pfam; PF07738; Sad1_UNC; 1. KW Coiled coil; Membrane; Nuclear protein; Transmembrane. FT CHAIN 1 699 Sad1/unc-84-like protein 2. FT /FTId=PRO_0000218914. FT TRANSMEM 195 215 Potential. FT DOMAIN 583 699 Unc84. FT COILED 259 275 Potential. FT COILED 334 420 Potential. FT COILED 458 487 Potential. SQ SEQUENCE 699 AA; 78195 MW; 991F96BE094BAFA8 CRC64; MSRRSQRLTR YSQDDNDGGS SSSGASSVAG SQGTVFKDSP LRTLKRKSSN MKHLSPAPQL GPSSDSHTSY YSESVVRESY IGSPRAVSLA RSALLDDHLH SEPYWSGDLR GRRRRGTGGS ESSKANGLTA ESKASEDFFG SSSGYSSEDD LAGRLFGLLY WWIGTTWYRL TTAASLLDVF VLTRSRHFSL NLKSFLWFLL LLLLLTGLTY GAWHFYPLGL QTLQPAVVSW WAAKESRKQP EVWESRDASQ HFQAEQRVLS RVHSLERRLE ALAADFSSNW QKEAIRLERL ELRQGAAGHG GGSSLSHEDA LSLLEGLVSR REATLKEDLR RDTVAHIQEE LATLRAEHHQ DSEDLFKKIV QASQESEARV QQLKTEWKSV TQEAFQESSV KELGRLEAQL ASLRQELAAL TLKQNSVAYE VGLLPQKIQA ARADVESQFP DWIRQFLLGD RGARSGLLQR DEMHAQLQEL ENKILTKMAE MQGKSAREAA ASLGQILQKE GIVGVTEEQV HRIVKQALQR YSEDRIGMVD YALESGGASV ISTRCSETYE TKTALLSLFG IPLWYHSQSP RVILQPDVHP GNCWAFQGPQ GFAVVRLSAR IRPTAVTLEH VPKALSPNST ISSAPKDFAI FGFDEDLQQE GTLLGTFAYD QDGEPIQTFY FQASKMATYQ VVELRILTNW GHPEYTCIYR FRVHGEPAH //