ID S45A1_MOUSE Reviewed; 751 AA. AC Q8BIV7; Q3TZ98; DT 24-OCT-2003, integrated into UniProtKB/Swiss-Prot. DT 16-MAY-2006, sequence version 3. DT 23-FEB-2022, entry version 123. DE RecName: Full=Proton-associated sugar transporter A; DE Short=PAST-A; DE AltName: Full=Deleted in neuroblastoma 5 protein homolog; DE Short=DNb-5 homolog; DE AltName: Full=Solute carrier family 45 member 1; GN Name=Slc45a1; Synonyms=Dnb5; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6J; TISSUE=Cerebellum, and Inner ear; RX PubMed=16141072; DOI=10.1126/science.1112014; RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J., RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.; RT "The transcriptional landscape of the mammalian genome."; RL Science 309:1559-1563(2005). RN [2] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-500, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Brain; RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and expression."; RL Cell 143:1174-1189(2010). CC -!- FUNCTION: Proton-associated glucose transporter in the brain. CC {ECO:0000250|UniProtKB:Q8K4S3}. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9Y2W3}; Multi- CC pass membrane protein {ECO:0000255}. CC -!- SIMILARITY: Belongs to the glycoside-pentoside-hexuronide (GPH) cation CC symporter transporter (TC 2.A.2) family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=AK082651; Type=Frameshift; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK082651; -; NOT_ANNOTATED_CDS; mRNA. DR EMBL; AK158002; BAE34311.1; -; mRNA. DR CCDS; CCDS18973.1; -. DR RefSeq; NP_776135.2; NM_173774.3. DR STRING; 10090.ENSMUSP00000036774; -. DR iPTMnet; Q8BIV7; -. DR PhosphoSitePlus; Q8BIV7; -. DR SwissPalm; Q8BIV7; -. DR PaxDb; Q8BIV7; -. DR PRIDE; Q8BIV7; -. DR ProteomicsDB; 260905; -. DR Antibodypedia; 57179; 10 antibodies from 4 providers. DR DNASU; 242773; -. DR Ensembl; ENSMUST00000037827; ENSMUSP00000036774; ENSMUSG00000039838. DR GeneID; 242773; -. DR KEGG; mmu:242773; -. DR UCSC; uc008vxt.1; mouse. DR CTD; 50651; -. DR MGI; MGI:2653235; Slc45a1. DR VEuPathDB; HostDB:ENSMUSG00000039838; -. DR eggNOG; KOG0637; Eukaryota. DR GeneTree; ENSGT00950000182914; -. DR HOGENOM; CLU_015081_1_0_1; -. DR InParanoid; Q8BIV7; -. DR OMA; DGTKRGM; -. DR OrthoDB; 1230185at2759; -. DR PhylomeDB; Q8BIV7; -. DR TreeFam; TF325412; -. DR BioGRID-ORCS; 242773; 0 hits in 63 CRISPR screens. DR PRO; PR:Q8BIV7; -. DR Proteomes; UP000000589; Chromosome 4. DR RNAct; Q8BIV7; protein. DR Bgee; ENSMUSG00000039838; Expressed in primary visual cortex and 121 other tissues. DR ExpressionAtlas; Q8BIV7; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0016020; C:membrane; IBA:GO_Central. DR GO; GO:0005355; F:glucose transmembrane transporter activity; ISO:MGI. DR GO; GO:0008506; F:sucrose:proton symporter activity; IBA:GO_Central. DR GO; GO:1904659; P:glucose transmembrane transport; ISO:MGI. DR Gene3D; 1.20.1250.20; -; 2. DR InterPro; IPR011701; MFS. DR InterPro; IPR036259; MFS_trans_sf. DR Pfam; PF07690; MFS_1; 1. DR SUPFAM; SSF103473; SSF103473; 1. PE 1: Evidence at protein level; KW Membrane; Phosphoprotein; Reference proteome; Sugar transport; Symport; KW Transmembrane; Transmembrane helix; Transport. FT CHAIN 1..751 FT /note="Proton-associated sugar transporter A" FT /id="PRO_0000122515" FT TRANSMEM 93..113 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 123..143 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 155..175 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 191..211 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 233..253 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 268..288 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 536..556 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 576..596 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 606..626 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 630..650 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 688..708 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 710..730 FT /note="Helical" FT /evidence="ECO:0000255" FT MOD_RES 500 FT /note="Phosphothreonine" FT /evidence="ECO:0007744|PubMed:21183079" FT CONFLICT 287 FT /note="S -> R (in Ref. 1; BAE34311)" FT /evidence="ECO:0000305" FT CONFLICT 433 FT /note="S -> L (in Ref. 1; BAE34311)" FT /evidence="ECO:0000305" SQ SEQUENCE 751 AA; 81474 MW; 129F390E154F6BBD CRC64; MIPPASSTPP GEAVIPSVAP QDFWRSPISS YSGSVTGHIS HRANNFKRHP KRRKYIRPSP PPPPNTPCPI ELVDFGDLHP QRSFWELLFN GCILFGIEFS YAMETAYVTP VLLQMGLPDQ LYSLVWFISP ILGFLLQPLL GAWSDRCTSR FGRRRPFILV LAIGALLGLS LLLNGRDIGM ALADTATNHK WGILLTVCGV VLMDFSADSA DNPSHAYMMD VCGPVDQDRG LNIHALMAGL GGGFGYVVGG IHWDKTSFGR ALGGQLRVIY VFTAITLSVT TVLTLISIPE RPLRPLGEKR TAMKSPSLPL PPSPPVLLEE GAGDALPSTT ATSLYASFSS PISPPSPLTP KYGSFISRDS SLTGINEFAS SFGTSNIDSV LIDCFTAGHD NYLALPSSVP RQAISVSFPR APDGFYCQER GLERREGPLT LGSDGDVLRV GSLDTSKPRA SGILKRPQTL ALPDVAGGNG PETSRRRNVT FSQQVANILL NGVKYESELT GSSEQSEQPL SLRHLCSTIY NMPKALRNLC VNHFLGWLSF EGMLLFYTDF MGEVVFQGDP KAPHTSEAYQ KYNSGVTMGC WGMCIYAFSA AFYSAILEKL EECLSVRTLY FIAYLAFGLG TGLATLSRNL YVVLSLCTTY GILFSTLCTL PYSLLCDYYQ SKKFAGSSAD GTRRGMGVDI SLLSCQYFLA QILVSLVLGP LTSAVGSANG VMYFSSLVSF LGCLYSSLCV TYEIPSVDAA DEERQPLLLN V //