ID T255A_MOUSE Reviewed; 351 AA. AC Q8BHW5; Q6P5C9; Q8BHV8; Q8BHZ6; DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot. DT 01-MAR-2003, sequence version 1. DT 07-NOV-2018, entry version 94. DE RecName: Full=Transmembrane protein 255A; DE AltName: Full=Protein FAM70A; GN Name=Tmem255a; Synonyms=Fam70a; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3). RC STRAIN=C57BL/6J; TISSUE=Olfactory bulb, Testis, and Thymus; RX PubMed=16141072; DOI=10.1126/science.1112014; RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E., RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., RA Hayashizaki Y.; RT "The transcriptional landscape of the mammalian genome."; RL Science 309:1559-1563(2005). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC STRAIN=C57BL/6J; TISSUE=Eye; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [3] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Testis; RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and RT expression."; RL Cell 143:1174-1189(2010). CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane CC protein {ECO:0000305}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1; CC IsoId=Q8BHW5-1; Sequence=Displayed; CC Name=2; CC IsoId=Q8BHW5-2; Sequence=VSP_021922; CC Note=No experimental confirmation available.; CC Name=3; CC IsoId=Q8BHW5-3; Sequence=VSP_021923; CC Note=No experimental confirmation available.; CC -!- SIMILARITY: Belongs to the TMEM255 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK041985; BAC31122.1; -; mRNA. DR EMBL; AK077178; BAC36664.1; -; mRNA. DR EMBL; AK078264; BAC37196.1; -; mRNA. DR EMBL; BC062956; AAH62956.1; -; mRNA. DR CCDS; CCDS30089.1; -. [Q8BHW5-1] DR CCDS; CCDS72367.1; -. [Q8BHW5-2] DR CCDS; CCDS81122.1; -. [Q8BHW5-3] DR RefSeq; NP_001276656.1; NM_001289727.1. [Q8BHW5-3] DR RefSeq; NP_001276657.1; NM_001289728.1. [Q8BHW5-2] DR RefSeq; NP_766518.3; NM_172930.4. [Q8BHW5-1] DR UniGene; Mm.72979; -. DR STRING; 10090.ENSMUSP00000064511; -. DR iPTMnet; Q8BHW5; -. DR PhosphoSitePlus; Q8BHW5; -. DR PaxDb; Q8BHW5; -. DR PRIDE; Q8BHW5; -. DR Ensembl; ENSMUST00000066498; ENSMUSP00000064511; ENSMUSG00000036502. [Q8BHW5-1] DR Ensembl; ENSMUST00000089054; ENSMUSP00000086455; ENSMUSG00000036502. [Q8BHW5-2] DR Ensembl; ENSMUST00000089056; ENSMUSP00000086457; ENSMUSG00000036502. [Q8BHW5-3] DR GeneID; 245386; -. DR KEGG; mmu:245386; -. DR UCSC; uc009szr.3; mouse. [Q8BHW5-1] DR UCSC; uc009szs.3; mouse. [Q8BHW5-2] DR UCSC; uc033jpk.1; mouse. [Q8BHW5-3] DR CTD; 55026; -. DR MGI; MGI:3045722; Tmem255a. DR eggNOG; ENOG410IDX1; Eukaryota. DR eggNOG; ENOG4110229; LUCA. DR GeneTree; ENSGT00390000008002; -. DR HOGENOM; HOG000230931; -. DR HOVERGEN; HBG056016; -. DR InParanoid; Q8BHW5; -. DR OMA; HSSVFPA; -. DR OrthoDB; EOG091G0GBU; -. DR PhylomeDB; Q8BHW5; -. DR TreeFam; TF331034; -. DR PRO; PR:Q8BHW5; -. DR Proteomes; UP000000589; Chromosome X. DR Bgee; ENSMUSG00000036502; Expressed in 203 organ(s), highest expression level in substantia nigra. DR CleanEx; MM_6430550H21RIK; -. DR Genevisible; Q8BHW5; MM. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0009617; P:response to bacterium; IEP:MGI. DR InterPro; IPR028014; TMEM255. DR PANTHER; PTHR33721; PTHR33721; 1. DR Pfam; PF14967; FAM70; 1. PE 1: Evidence at protein level; KW Alternative splicing; Complete proteome; Membrane; Reference proteome; KW Transmembrane; Transmembrane helix. FT CHAIN 1 351 Transmembrane protein 255A. FT /FTId=PRO_0000266039. FT TRANSMEM 30 50 Helical. {ECO:0000255}. FT TRANSMEM 57 77 Helical. {ECO:0000255}. FT TRANSMEM 89 109 Helical. {ECO:0000255}. FT TRANSMEM 226 246 Helical. {ECO:0000255}. FT COMPBIAS 285 351 Pro-rich. FT VAR_SEQ 119 141 Missing (in isoform 2). FT {ECO:0000303|PubMed:16141072}. FT /FTId=VSP_021922. FT VAR_SEQ 298 351 HSGVFPSSPPSGLSDEQEPQSPSPSPSYMWSSSAPPRYSPP FT YYPPFEKPPPYSP -> VFSWCVEKYSRHSKTTGNANLLLT FT AMVQETMGRA (in isoform 3). FT {ECO:0000303|PubMed:16141072}. FT /FTId=VSP_021923. FT CONFLICT 49 49 A -> T (in Ref. 1; BAC37196). FT {ECO:0000305}. FT CONFLICT 321 321 P -> R (in Ref. 2; AAH62956). FT {ECO:0000305}. SQ SEQUENCE 351 AA; 38633 MW; C6B3F7AFBAFAC52E CRC64; MHQSLTQQRS SDMSLPDSMG AFNRRKRNSI YVTVTLLIVS MLILTVGLAA TTRTQNVTVG GYYPGVILGF GSFLGIIGSN LIENKRQMLV ASIVFISFGV IAAFCCAIVD GVFAARHIDL KPLYANRCHY VPKTSQREAE EVITSSSKIT PSTRALRNLT QAVKEVNCPQ LSRGLCTPRI RGNTCFCCDL YNCGNRVEIT GGYYEYIDVS SCQDIIHLYH LLWSATILNI VGLFLGIITA AVLGGFKDMN PTLPALNCSV ENAHPTVSYY ARPQVASYNT YYHSPPHLPP YSAYDFQHSG VFPSSPPSGL SDEQEPQSPS PSPSYMWSSS APPRYSPPYY PPFEKPPPYS P //