ID VME1_CVP67 Reviewed; 230 AA. AC Q8BB24; DT 11-JUL-2003, integrated into UniProtKB/Swiss-Prot. DT 01-MAR-2003, sequence version 1. DT 22-FEB-2023, entry version 88. DE RecName: Full=Membrane protein {ECO:0000255|HAMAP-Rule:MF_04202}; DE Short=M protein {ECO:0000255|HAMAP-Rule:MF_04202}; DE AltName: Full=E1 glycoprotein {ECO:0000255|HAMAP-Rule:MF_04202}; DE AltName: Full=Matrix glycoprotein {ECO:0000255|HAMAP-Rule:MF_04202}; DE AltName: Full=Membrane glycoprotein {ECO:0000255|HAMAP-Rule:MF_04202}; GN Name=M {ECO:0000255|HAMAP-Rule:MF_04202}; OS Porcine hemagglutinating encephalomyelitis virus (strain 67N) (HEV-67N). OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; OC Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae; OC Betacoronavirus; Embecovirus. OX NCBI_TaxID=230237; OH NCBI_TaxID=9823; Sus scrofa (Pig). RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC RNA]. RX PubMed=12237422; DOI=10.1099/0022-1317-83-10-2411; RA Sasseville A.M.-J., Boutin M., Gelinas A.-M., Dea S.; RT "Sequence of the 3'-terminal end (8.1 kb) of the genome of porcine RT haemagglutinating encephalomyelitis virus: comparison with other RT haemagglutinating coronaviruses."; RL J. Gen. Virol. 83:2411-2416(2002). CC -!- FUNCTION: Component of the viral envelope that plays a central role in CC virus morphogenesis and assembly via its interactions with other viral CC proteins. {ECO:0000255|HAMAP-Rule:MF_04202, ECO:0000255|PROSITE- CC ProRule:PRU01275}. CC -!- SUBUNIT: Homomultimer. Interacts with envelope E protein in the budding CC compartment of the host cell, which is located between endoplasmic CC reticulum and the Golgi complex. Forms a complex with HE and S CC proteins. Interacts with nucleocapsid N protein. This interaction CC probably participates in RNA packaging into the virus. CC {ECO:0000255|HAMAP-Rule:MF_04202, ECO:0000255|PROSITE- CC ProRule:PRU01275}. CC -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000255|HAMAP- CC Rule:MF_04202}; Multi-pass membrane protein {ECO:0000255|HAMAP- CC Rule:MF_04202}. Host Golgi apparatus membrane {ECO:0000255|HAMAP- CC Rule:MF_04202}; Multi-pass membrane protein {ECO:0000255|HAMAP- CC Rule:MF_04202}. Note=Largely embedded in the lipid bilayer. CC {ECO:0000255|HAMAP-Rule:MF_04202}. CC -!- SIMILARITY: Belongs to the betacoronaviruses M protein family. CC {ECO:0000255|HAMAP-Rule:MF_04202}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY078417; AAL80035.1; -; Genomic_RNA. DR Proteomes; UP000007546; Genome. DR GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-UniRule. DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell. DR GO; GO:0039660; F:structural constituent of virion; IEA:UniProtKB-UniRule. DR GO; GO:0019049; P:mitigation of host antiviral defense response; IEA:UniProtKB-KW. DR CDD; cd21568; HCoV-like_M; 1. DR HAMAP; MF_04202; BETA_CORONA_M; 1. DR InterPro; IPR002574; M_CoV. DR InterPro; IPR044362; M_HCoV-like. DR Pfam; PF01635; CoV_M; 1. DR PROSITE; PS51927; COV_M; 1. PE 3: Inferred from homology; KW Glycoprotein; Host Golgi apparatus; Host membrane; Host-virus interaction; KW Membrane; Transmembrane; Transmembrane helix; Viral envelope protein; KW Viral immunoevasion; Viral matrix protein; Virion. FT CHAIN 1..230 FT /note="Membrane protein" FT /id="PRO_0000106041" FT TOPO_DOM 1..24 FT /note="Virion surface" FT /evidence="ECO:0000255|HAMAP-Rule:MF_04202" FT TRANSMEM 25..45 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_04202" FT TOPO_DOM 46..55 FT /note="Intravirion" FT /evidence="ECO:0000255|HAMAP-Rule:MF_04202" FT TRANSMEM 56..76 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_04202" FT TOPO_DOM 77..84 FT /note="Virion surface" FT /evidence="ECO:0000255|HAMAP-Rule:MF_04202" FT TRANSMEM 85..105 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_04202" FT TOPO_DOM 106..228 FT /note="Intravirion" FT /evidence="ECO:0000255|HAMAP-Rule:MF_04202" SQ SEQUENCE 230 AA; 26287 MW; 1820EFAE161F26C4 CRC64; MSSPTTPVPV ISWTADEAIK FLKEWNFSLG IIVLFITIIL QFGYTSRSMF VYVIKMVILW LMWPLTIILT IFNCVYALNN VYLGFSIVFT IVAIIMWVVY FVNSIRLFIR TGSWWSFNPE TNNLMCIDMK GRMYVRPIIE DYHTLTATII RGHLYIQGIK LGTGYSLSDL PAYVTVAKVT HLCTYKRGFL DRIGDTSGFA VYVKSKVGNY RLPSTHKGSG MDTALLRNNI //