ID VME1_CVP67 Reviewed; 230 AA. AC Q8BB24; DT 11-JUL-2003, integrated into UniProtKB/Swiss-Prot. DT 01-MAR-2003, sequence version 1. DT 29-APR-2008, entry version 32. DE Membrane protein (M protein) (Membrane glycoprotein) (E1 glycoprotein) DE (Matrix glycoprotein). GN Name=M; OS Porcine hemagglutinating encephalomyelitis virus (strain 67N) OS (HEV-67N). OC Viruses; ssRNA positive-strand viruses, no DNA stage; Nidovirales; OC Coronaviridae; Coronavirus; Coronavirus group 2; Coronavirus group 2a. OX NCBI_TaxID=230237; OH NCBI_TaxID=9823; Sus scrofa (Pig). RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC RNA]. RX MEDLINE=22222597; PubMed=12237422; RA Sasseville A.M.-J., Boutin M., Gelinas A.-M., Dea S.; RT "Sequence of the 3'-terminal end (8.1 kb) of the genome of porcine RT haemagglutinating encephalomyelitis virus: comparison with other RT haemagglutinating coronaviruses."; RL J. Gen. Virol. 83:2411-2416(2002). CC -!- FUNCTION: Component of the viral envelope that plays a central CC role in virus morphogenesis and assembly via its interactions with CC other viral proteins (By similarity). CC -!- SUBUNIT: Homomultimer. Interacts with envelope E protein in the CC budding compartment of the host cell, which is located between CC endoplasmic reticulum and the Golgi complex. Forms a complex with CC HE and S proteins. Interacts with nucleocapsid N protein. This CC interaction probably participates in RNA packaging into the virus CC (By similarity). CC -!- SUBCELLULAR LOCATION: Virion membrane; Multi-pass membrane protein CC (Potential). Golgi apparatus membrane; Multi-pass membrane protein CC (Potential). Note=Largely embedded in the lipid bilayer (By CC similarity). CC -!- PTM: O-linked glycans consist of Gal-GalNAc disaccharides which CC are modified with up to 2 sialic acid residues (By similarity). CC -!- SIMILARITY: Belongs to the coronaviruses M protein family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY078417; AAL80035.1; -; Genomic_RNA. DR InterPro; IPR002574; Corona_M. DR Pfam; PF01635; Corona_M; 1. PE 3: Inferred from homology; KW Complete proteome; Envelope protein; Glycoprotein; Golgi apparatus; KW Membrane; Transmembrane; Viral matrix protein; Virion. FT CHAIN 1 230 Membrane protein. FT /FTId=PRO_0000106041. FT TOPO_DOM 1 28 Lumenal (Potential). FT TRANSMEM 29 45 Potential. FT TOPO_DOM 46 48 Cytoplasmic (Potential). FT TRANSMEM 49 69 Potential. FT TOPO_DOM 70 80 Lumenal (Potential). FT TRANSMEM 81 101 Potential. FT TOPO_DOM 102 230 Cytoplasmic (Potential). FT CARBOHYD 2 2 O-linked (GalNAc...) (By similarity). FT CARBOHYD 3 3 O-linked (GalNAc...) (By similarity). FT CARBOHYD 5 5 O-linked (GalNAc...) (By similarity). FT CARBOHYD 6 6 O-linked (GalNAc...) (By similarity). FT CARBOHYD 14 14 O-linked (GalNAc...) (By similarity). FT CARBOHYD 28 28 O-linked (GalNAc...) (By similarity). SQ SEQUENCE 230 AA; 26287 MW; 1820EFAE161F26C4 CRC64; MSSPTTPVPV ISWTADEAIK FLKEWNFSLG IIVLFITIIL QFGYTSRSMF VYVIKMVILW LMWPLTIILT IFNCVYALNN VYLGFSIVFT IVAIIMWVVY FVNSIRLFIR TGSWWSFNPE TNNLMCIDMK GRMYVRPIIE DYHTLTATII RGHLYIQGIK LGTGYSLSDL PAYVTVAKVT HLCTYKRGFL DRIGDTSGFA VYVKSKVGNY RLPSTHKGSG MDTALLRNNI //