ID VME1_CVP67 Reviewed; 230 AA. AC Q8BB24; DT 11-JUL-2003, integrated into UniProtKB/Swiss-Prot. DT 01-MAR-2003, sequence version 1. DT 23-JAN-2007, entry version 24. DE E1 glycoprotein (Matrix glycoprotein) (Membrane glycoprotein). GN Name=M; OS Porcine hemagglutinating encephalomyelitis virus (strain 67N) OS (HEV-67N). OC Viruses; ssRNA positive-strand viruses, no DNA stage; Nidovirales; OC Coronaviridae; Coronavirus; Group 2 species. OX NCBI_TaxID=230237; OH NCBI_TaxID=9823; Sus scrofa (Pig). RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC RNA]. RX MEDLINE=22222597; PubMed=12237422; RA Sasseville A.M.-J., Boutin M., Gelinas A.-M., Dea S.; RT "Sequence of the 3'-terminal end (8.1 kb) of the genome of porcine RT haemagglutinating encephalomyelitis virus: comparison with other RT haemagglutinating coronaviruses."; RL J. Gen. Virol. 83:2411-2416(2002). CC -!- FUNCTION: Component of the viral envelope that plays a central CC role in virus morphogenesis and assembly via its interactions with CC other viral proteins (By similarity). CC -!- SUBUNIT: Interacts with many viral proteins in infected cells. CC Interacts with envelope E protein in the budding compartment of CC the host cell, which is located between endoplasmic reticulum and CC the Golgi complex. These two proteins are sufficient for the CC formation of virus-like particles. Forms a complex with HE and S CC proteins. Interacts with nucleocapsid N protein. This interaction CC probably participates in the viral mRNA packaging into the virus CC (By similarity). CC -!- SUBCELLULAR LOCATION: Virion (By similarity). Golgi apparatus; CC Golgi apparatus membrane; multi-pass membrane protein (By CC similarity). Note=Largely embedded in the lipid bilayer. In CC infected cells, it is located in Golgi membranes (By similarity). CC -!- PTM: O-linked glycans consist of Gal-GalNAc disaccharides which CC are modified with up to 2 sialic acid residues (By similarity). CC -!- SIMILARITY: Belongs to the coronaviruses M protein family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY078417; AAL80035.1; -; Genomic_RNA. DR InterPro; IPR002574; Corona_M. DR Pfam; PF01635; Corona_M; 1. KW Envelope protein; Glycoprotein; Membrane; Transmembrane; KW Viral matrix protein; Virion protein. FT CHAIN 1 230 E1 glycoprotein. FT /FTId=PRO_0000106041. FT TRANSMEM 29 44 Potential. FT TRANSMEM 49 71 Potential. FT TRANSMEM 81 103 Potential. FT CARBOHYD 2 2 O-linked (GalNAc...) (By similarity). FT CARBOHYD 3 3 O-linked (GalNAc...) (By similarity). FT CARBOHYD 5 5 O-linked (GalNAc...) (By similarity). FT CARBOHYD 6 6 O-linked (GalNAc...) (By similarity). FT CARBOHYD 14 14 O-linked (GalNAc...) (By similarity). FT CARBOHYD 28 28 O-linked (GalNAc...) (By similarity). SQ SEQUENCE 230 AA; 26287 MW; 1820EFAE161F26C4 CRC64; MSSPTTPVPV ISWTADEAIK FLKEWNFSLG IIVLFITIIL QFGYTSRSMF VYVIKMVILW LMWPLTIILT IFNCVYALNN VYLGFSIVFT IVAIIMWVVY FVNSIRLFIR TGSWWSFNPE TNNLMCIDMK GRMYVRPIIE DYHTLTATII RGHLYIQGIK LGTGYSLSDL PAYVTVAKVT HLCTYKRGFL DRIGDTSGFA VYVKSKVGNY RLPSTHKGSG MDTALLRNNI //