ID Q89462_9VIRU Unreviewed; 428 AA. AC Q89462; DT 01-NOV-1996, integrated into UniProtKB/TrEMBL. DT 01-NOV-1996, sequence version 1. DT 18-JUL-2018, entry version 84. DE SubName: Full=Nucleocapsid protein {ECO:0000313|EMBL:AAC42203.1}; OS Sin Nombre orthohantavirus. OC Viruses; ssRNA viruses; ssRNA negative-strand viruses; Bunyavirales; OC Hantaviridae; Orthohantavirus. OX NCBI_TaxID=1980491 {ECO:0000313|EMBL:AAC42203.1, ECO:0000313|Proteomes:UP000167429}; RN [1] {ECO:0000313|EMBL:AAA75529.1, ECO:0000313|Proteomes:UP000204632} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=NM H10 {ECO:0000313|EMBL:AAA75529.1}; RX PubMed=8178455; DOI=10.1006/viro.1994.1235; RA Spiropoulou C.F., Morzunov S., Feldmann H., Sanchez A., Peters C.J., RA Nichol S.T.; RT "Genome structure and variability of a virus causing hantavirus RT pulmonary syndrome."; RL Virology 200:715-723(1994). RN [2] {ECO:0000313|EMBL:AAC42203.1, ECO:0000313|Proteomes:UP000167429, ECO:0000313|Proteomes:UP000204632} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=7494336; RA Chizhikov V.E., Spiropoulou C.F., Morzunov S.P., Monroe M.C., RA Peters C.J., Nichol S.T.; RT "Complete genetic characterization and analysis of isolation of Sin RT Nombre virus."; RL J. Virol. 69:8132-8136(1995). RN [3] {ECO:0000213|PDB:2IC6, ECO:0000213|PDB:2IC9} RP X-RAY CRYSTALLOGRAPHY (1.15 ANGSTROMS) OF 1-75. RX PubMed=17222867; DOI=10.1016/j.jmb.2006.12.046; RA Boudko S.P., Kuhn R.J., Rossmann M.G.; RT "The coiled-coil domain structure of the Sin Nombre virus nucleocapsid RT protein."; RL J. Mol. Biol. 366:1538-1544(2007). RN [4] {ECO:0000313|EMBL:AFV71286.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=1 {ECO:0000313|EMBL:AFV71286.1}, and 2 RC {ECO:0000313|EMBL:AFV71287.1}; RX PubMed=23110096; DOI=10.1371/journal.pone.0047731; RA Bagamian K.H., Towner J.S., Kuenzi A.J., Douglass R.J., Rollin P.E., RA Waller L.A., Mills J.N.; RT "Transmission ecology of sin nombre hantavirus in naturally infected RT north american deermouse populations in outdoor enclosures."; RL PLoS ONE 7:E47731-E47731(2012). RN [5] {ECO:0000313|EMBL:AFV71284.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=1 {ECO:0000313|EMBL:AFV71284.1}; RA Bagamian K.H.; RT "Evolution of Sin Nombre hantavirus in Montana."; RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases. RN [6] {ECO:0000313|EMBL:AIA08877.1, ECO:0000313|Proteomes:UP000113911} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Sin Nombre virus 77734 {ECO:0000313|EMBL:AIA08877.1}; RX PubMed=24778254; DOI=10.1073/pnas.1401998111; RA Safronetz D., Prescott J., Feldmann F., Haddock E., Rosenke R., RA Okumura A., Brining D., Dahlstrom E., Porcella S.F., Ebihara H., RA Scott D.P., Hjelle B., Feldmann H.; RT "Pathophysiology of hantavirus pulmonary syndrome in rhesus RT macaques."; RL Proc. Natl. Acad. Sci. U.S.A. 111:7114-7119(2014). RN [7] {ECO:0000213|PDB:5E05, ECO:0000213|PDB:5E06} RP X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 114-397. RX PubMed=26559827; DOI=10.1128/JVI.02523-15; RA Guo Y., Wang W., Sun Y., Ma C., Wang X., Wang X., Liu P., Shen S., RA Li B., Lin J., Deng F., Wang H., Lou Z.; RT "Crystal Structure of the Core Region of Hantavirus Nucleocapsid RT Protein Reveals the Mechanism for Ribonucleoprotein Complex RT Formation."; RL J. Virol. 90:1048-1061(2016). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L25784; AAA75529.1; -; Viral_cRNA. DR EMBL; L37904; AAC42203.1; -; Genomic_RNA. DR EMBL; JQ690281; AFV71284.1; -; Viral_cRNA. DR EMBL; JQ690276; AFV71286.1; -; Viral_cRNA. DR EMBL; JQ690277; AFV71287.1; -; Viral_cRNA. DR EMBL; KF537003; AIA08877.1; -; Viral_cRNA. DR EMBL; KF537006; AIA08880.1; -; Viral_cRNA. DR RefSeq; NP_941975.1; NC_005216.1. DR PDB; 2IC6; X-ray; 1.15 A; A/B=1-75. DR PDB; 2IC9; X-ray; 2.00 A; A/B=1-93. DR PDB; 5E05; X-ray; 2.30 A; A=114-397. DR PDB; 5E06; X-ray; 3.00 A; A=114-397. DR PDBsum; 2IC6; -. DR PDBsum; 2IC9; -. DR PDBsum; 5E05; -. DR PDBsum; 5E06; -. DR SMR; Q89462; -. DR GeneID; 2943142; -. DR KEGG; vg:2943142; -. DR Proteomes; UP000113911; Genome. DR Proteomes; UP000167429; Genome. DR Proteomes; UP000204632; Genome. DR GO; GO:0019013; C:viral nucleocapsid; IEA:UniProtKB-KW. DR InterPro; IPR002214; Hanta_nucleocap. DR Pfam; PF00846; Hanta_nucleocap; 1. DR PIRSF; PIRSF003949; N_HantaV; 1. DR ProDom; PD001501; Hanta_nucleocap; 1. PE 1: Evidence at protein level; KW 3D-structure {ECO:0000213|PDB:2IC6, ECO:0000213|PDB:2IC9, KW ECO:0000213|PDB:5E05, ECO:0000213|PDB:5E06}; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000113911, KW ECO:0000313|Proteomes:UP000167429, ECO:0000313|Proteomes:UP000204632}; KW Viral nucleoprotein {ECO:0000313|EMBL:AAC42203.1}; KW Virion {ECO:0000313|EMBL:AAC42203.1}. FT COILED 4 31 {ECO:0000256|SAM:Coils}. FT COILED 44 71 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 428 AA; 48177 MW; E93C4B4A8B45F477 CRC64; MSTLKEVQDN ITLHEQQLVT ARQKLKDAER AVELDPDDVN KSTLQSRRAA VSALETKLGE LKRELADLIA AQKLASKPVD PTGIEPDDHL KEKSSLRYGN VLDVNSIDLE EPSGQTADWK SIGLYILSFA LPIILKALYM LSTRGRQTIK ENKGTRIRFK DDSSYEEVNG IRKPRHLYVS MPTAQSTMKA DEITPGRFRT IACGLFPAQV KARNIISPVM GVIGFSFFVK DWMERIDDFL AARCPFLPEQ KDPRDAALAT NRAYFITRQL QVDESKVSDI EDLIADARAE SATIFADIAT PHSVWVFACA PDRCPPTALY VAGMPELGAF FAILQDMRNT IMASKSVGTS EEKLKKKSAF YQSYLRRTQS MGIQLDQKII ILYMSHWGRE AVNHFHLGDD MDPELRELAQ TLVDIKVREI SNQEPLKL //