ID Q89462_9VIRU Unreviewed; 428 AA. AC Q89462; DT 01-NOV-1996, integrated into UniProtKB/TrEMBL. DT 01-NOV-1996, sequence version 1. DT 29-APR-2015, entry version 56. DE RecName: Full=Nucleoprotein {ECO:0000256|PIRNR:PIRNR003949}; DE AltName: Full=Nucleocapsid protein {ECO:0000256|PIRNR:PIRNR003949}; OS Sin Nombre virus. OC Viruses; ssRNA negative-strand viruses; Bunyaviridae; Hantavirus. OX NCBI_TaxID=37705 {ECO:0000313|EMBL:AAC42203.1}; RN [1] {ECO:0000313|EMBL:AAA75529.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=NM H10 {ECO:0000313|EMBL:AAA75529.1}; RX PubMed=8178455; DOI=10.1006/viro.1994.1235; RA Spiropoulou C.F., Morzunov S., Feldmann H., Sanchez A., Peters C.J., RA Nichol S.T.; RT "Genome structure and variability of a virus causing hantavirus RT pulmonary syndrome."; RL Virology 200:715-723(1994). RN [2] {ECO:0000313|EMBL:AAC42203.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=7494336; RA Chizhikov V.E., Spiropoulou C.F., Morzunov S.P., Monroe M.C., RA Peters C.J., Nichol S.T.; RT "Complete genetic characterization and analysis of isolation of Sin RT Nombre virus."; RL J. Virol. 69:8132-8136(1995). RN [3] {ECO:0000213|PDB:2IC6, ECO:0000213|PDB:2IC9} RP X-RAY CRYSTALLOGRAPHY (1.15 ANGSTROMS) OF 1-75. RX PubMed=17222867; DOI=10.1016/j.jmb.2006.12.046; RA Boudko S.P., Kuhn R.J., Rossmann M.G.; RT "The coiled-coil domain structure of the Sin Nombre virus nucleocapsid RT protein."; RL J. Mol. Biol. 366:1538-1544(2007). RN [4] {ECO:0000313|EMBL:AFV71286.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=1 {ECO:0000313|EMBL:AFV71286.1}, and 2 RC {ECO:0000313|EMBL:AFV71287.1}; RX PubMed=23110096; DOI=10.1371/journal.pone.0047731; RA Bagamian K.H., Towner J.S., Kuenzi A.J., Douglass R.J., Rollin P.E., RA Waller L.A., Mills J.N.; RT "Transmission ecology of sin nombre hantavirus in naturally infected RT north american deermouse populations in outdoor enclosures."; RL PLoS ONE 7:E47731-E47731(2012). RN [5] {ECO:0000313|EMBL:AFV71284.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=1 {ECO:0000313|EMBL:AFV71284.1}; RA Bagamian K.H.; RT "Evolution of Sin Nombre hantavirus in Montana."; RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases. RN [6] {ECO:0000313|EMBL:AIA08877.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Sin Nombre virus 77734 {ECO:0000313|EMBL:AIA08877.1}; RX PubMed=24778254; DOI=10.1073/pnas.1401998111; RA Safronetz D., Prescott J., Feldmann F., Haddock E., Rosenke R., RA Okumura A., Brining D., Dahlstrom E., Porcella S.F., Ebihara H., RA Scott D.P., Hjelle B., Feldmann H.; RT "Pathophysiology of hantavirus pulmonary syndrome in rhesus RT macaques."; RL Proc. Natl. Acad. Sci. U.S.A. 111:7114-7119(2014). CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000256|PIRNR:PIRNR003949}. CC Note=Internal protein of virus particle. CC {ECO:0000256|PIRNR:PIRNR003949}. CC -!- SIMILARITY: Belongs to the hantavirus nucleocapsid protein family. CC {ECO:0000256|PIRNR:PIRNR003949}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L25784; AAA75529.1; -; Viral_cRNA. DR EMBL; L37904; AAC42203.1; -; Genomic_RNA. DR EMBL; JQ690281; AFV71284.1; -; Viral_cRNA. DR EMBL; JQ690276; AFV71286.1; -; Viral_cRNA. DR EMBL; JQ690277; AFV71287.1; -; Viral_cRNA. DR EMBL; KF537003; AIA08877.1; -; Viral_cRNA. DR EMBL; KF537006; AIA08880.1; -; Viral_cRNA. DR RefSeq; NP_941975.1; NC_005216.1. DR PDB; 2IC6; X-ray; 1.15 A; A/B=1-75. DR PDB; 2IC9; X-ray; 2.00 A; A/B=1-93. DR PDBsum; 2IC6; -. DR PDBsum; 2IC9; -. DR ProteinModelPortal; Q89462; -. DR SMR; Q89462; 1-75. DR GeneID; 2943142; -. DR KEGG; vg:2943142; -. DR GO; GO:0019013; C:viral nucleocapsid; IEA:UniProtKB-KW. DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW. DR InterPro; IPR002214; Hanta_nucleocap. DR Pfam; PF00846; Hanta_nucleocap; 1. DR PIRSF; PIRSF003949; N_HantaV; 1. DR ProDom; PD001501; Hanta_nucleocap; 1. PE 1: Evidence at protein level; KW 3D-structure {ECO:0000213|PDB:2IC6, ECO:0000213|PDB:2IC9}; KW Capsid protein {ECO:0000256|PIRNR:PIRNR003949}; KW Ribonucleoprotein {ECO:0000256|PIRNR:PIRNR003949}; KW RNA-binding {ECO:0000256|PIRNR:PIRNR003949}; KW Viral nucleoprotein {ECO:0000256|PIRNR:PIRNR003949, KW ECO:0000313|EMBL:AAC42203.1}; Virion {ECO:0000256|PIRNR:PIRNR003949}. SQ SEQUENCE 428 AA; 48177 MW; E93C4B4A8B45F477 CRC64; MSTLKEVQDN ITLHEQQLVT ARQKLKDAER AVELDPDDVN KSTLQSRRAA VSALETKLGE LKRELADLIA AQKLASKPVD PTGIEPDDHL KEKSSLRYGN VLDVNSIDLE EPSGQTADWK SIGLYILSFA LPIILKALYM LSTRGRQTIK ENKGTRIRFK DDSSYEEVNG IRKPRHLYVS MPTAQSTMKA DEITPGRFRT IACGLFPAQV KARNIISPVM GVIGFSFFVK DWMERIDDFL AARCPFLPEQ KDPRDAALAT NRAYFITRQL QVDESKVSDI EDLIADARAE SATIFADIAT PHSVWVFACA PDRCPPTALY VAGMPELGAF FAILQDMRNT IMASKSVGTS EEKLKKKSAF YQSYLRRTQS MGIQLDQKII ILYMSHWGRE AVNHFHLGDD MDPELRELAQ TLVDIKVREI SNQEPLKL //