ID Q89462_SINV Unreviewed; 428 AA. AC Q89462; DT 01-NOV-1996, integrated into UniProtKB/TrEMBL. DT 01-NOV-1996, sequence version 1. DT 19-JAN-2022, entry version 100. DE RecName: Full=Nucleoprotein {ECO:0000256|PIRNR:PIRNR003949}; OS Sin Nombre orthohantavirus (SNV) (Sin Nombre virus). OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina; OC Ellioviricetes; Bunyavirales; Hantaviridae; Mammantavirinae; OC Orthohantavirus. OX NCBI_TaxID=1980491 {ECO:0000313|EMBL:AAC42203.1, ECO:0000313|Proteomes:UP000167429}; OH NCBI_TaxID=9606; Homo sapiens (Human). OH NCBI_TaxID=10042; Peromyscus maniculatus (North American deer mouse). RN [1] {ECO:0000313|EMBL:AAA75529.1, ECO:0000313|Proteomes:UP000204632} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=NM H10 {ECO:0000313|EMBL:AAA75529.1}; RX PubMed=8178455; DOI=10.1006/viro.1994.1235; RA Spiropoulou C.F., Morzunov S., Feldmann H., Sanchez A., Peters C.J., RA Nichol S.T.; RT "Genome structure and variability of a virus causing hantavirus pulmonary RT syndrome."; RL Virology 200:715-723(1994). RN [2] {ECO:0000313|Proteomes:UP000167429, ECO:0000313|Proteomes:UP000204632} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=7494336; RA Chizhikov V.E., Spiropoulou C.F., Morzunov S.P., Monroe M.C., Peters C.J., RA Nichol S.T.; RT "Complete genetic characterization and analysis of isolation of Sin Nombre RT virus."; RL J. Virol. 69:8132-8136(1995). RN [3] {ECO:0007829|PDB:2IC6, ECO:0007829|PDB:2IC9} RP X-RAY CRYSTALLOGRAPHY (1.15 ANGSTROMS) OF 1-75. RX PubMed=17222867; DOI=10.1016/j.jmb.2006.12.046; RA Boudko S.P., Kuhn R.J., Rossmann M.G.; RT "The coiled-coil domain structure of the Sin Nombre virus nucleocapsid RT protein."; RL J. Mol. Biol. 366:1538-1544(2007). RN [4] {ECO:0000313|EMBL:AFV71286.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=1 {ECO:0000313|EMBL:AFV71286.1}, and 2 RC {ECO:0000313|EMBL:AFV71287.1}; RX PubMed=23110096; DOI=10.1371/journal.pone.0047731; RA Bagamian K.H., Towner J.S., Kuenzi A.J., Douglass R.J., Rollin P.E., RA Waller L.A., Mills J.N.; RT "Transmission ecology of sin nombre hantavirus in naturally infected north RT american deermouse populations in outdoor enclosures."; RL PLoS ONE 7:E47731-E47731(2012). RN [5] {ECO:0000313|EMBL:AFV71284.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=1 {ECO:0000313|EMBL:AFV71284.1}; RA Bagamian K.H.; RT "Evolution of Sin Nombre hantavirus in Montana."; RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases. RN [6] {ECO:0000313|EMBL:AIA08877.1, ECO:0000313|Proteomes:UP000113911} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Sin Nombre virus 77734 {ECO:0000313|EMBL:AIA08877.1}; RX PubMed=24778254; DOI=10.1073/pnas.1401998111; RA Safronetz D., Prescott J., Feldmann F., Haddock E., Rosenke R., Okumura A., RA Brining D., Dahlstrom E., Porcella S.F., Ebihara H., Scott D.P., Hjelle B., RA Feldmann H.; RT "Pathophysiology of hantavirus pulmonary syndrome in rhesus macaques."; RL Proc. Natl. Acad. Sci. U.S.A. 111:7114-7119(2014). RN [7] {ECO:0007829|PDB:5E05, ECO:0007829|PDB:5E06} RP X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 114-397. RX PubMed=26559827; DOI=10.1128/jvi.02523-15; RA Guo Y., Wang W., Sun Y., Ma C., Wang X., Wang X., Liu P., Shen S., Li B., RA Lin J., Deng F., Wang H., Lou Z.; RT "Crystal Structure of the Core Region of Hantavirus Nucleocapsid Protein RT Reveals the Mechanism for Ribonucleoprotein Complex Formation."; RL J. Virol. 90:1048-1061(2016). CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000256|ARBA:ARBA00004328}. CC -!- SIMILARITY: Belongs to the hantavirus nucleocapsid protein family. CC {ECO:0000256|ARBA:ARBA00007687, ECO:0000256|PIRNR:PIRNR003949}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L25784; AAA75529.1; -; Viral_cRNA. DR EMBL; L37904; AAC42203.1; -; Genomic_RNA. DR EMBL; JQ690281; AFV71284.1; -; Viral_cRNA. DR EMBL; JQ690276; AFV71286.1; -; Viral_cRNA. DR EMBL; JQ690277; AFV71287.1; -; Viral_cRNA. DR EMBL; KF537003; AIA08877.1; -; Viral_cRNA. DR EMBL; KF537006; AIA08880.1; -; Viral_cRNA. DR RefSeq; NP_941975.1; NC_005216.1. DR PDB; 2IC6; X-ray; 1.15 A; A/B=1-75. DR PDB; 2IC9; X-ray; 2.00 A; A/B=1-93. DR PDB; 5E05; X-ray; 2.30 A; A=114-397. DR PDB; 5E06; X-ray; 3.00 A; A=114-397. DR PDBsum; 2IC6; -. DR PDBsum; 2IC9; -. DR PDBsum; 5E05; -. DR PDBsum; 5E06; -. DR SMR; Q89462; -. DR GeneID; 2943142; -. DR KEGG; vg:2943142; -. DR Proteomes; UP000113911; Genome. DR Proteomes; UP000167429; Genome. DR Proteomes; UP000204632; Genome. DR GO; GO:0019029; C:helical viral capsid; IEA:UniProtKB-UniRule. DR GO; GO:0019013; C:viral nucleocapsid; IEA:UniProtKB-UniRule. DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule. DR InterPro; IPR002214; Hanta_nucleocap. DR Pfam; PF00846; Hanta_nucleocap; 1. DR PIRSF; PIRSF003949; N_HantaV; 1. PE 1: Evidence at protein level; KW 3D-structure {ECO:0007829|PDB:2IC6, ECO:0007829|PDB:2IC9}; KW Capsid protein {ECO:0000256|PIRNR:PIRNR003949}; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Ribonucleoprotein {ECO:0000256|PIRNR:PIRNR003949}; KW RNA-binding {ECO:0000256|PIRNR:PIRNR003949}; KW Viral nucleoprotein {ECO:0000256|PIRNR:PIRNR003949, KW ECO:0000313|EMBL:AAC42203.1}; Virion {ECO:0000256|PIRNR:PIRNR003949}. FT COILED 4..31 FT /evidence="ECO:0000256|SAM:Coils" FT COILED 44..71 FT /evidence="ECO:0000256|SAM:Coils" SQ SEQUENCE 428 AA; 48177 MW; E93C4B4A8B45F477 CRC64; MSTLKEVQDN ITLHEQQLVT ARQKLKDAER AVELDPDDVN KSTLQSRRAA VSALETKLGE LKRELADLIA AQKLASKPVD PTGIEPDDHL KEKSSLRYGN VLDVNSIDLE EPSGQTADWK SIGLYILSFA LPIILKALYM LSTRGRQTIK ENKGTRIRFK DDSSYEEVNG IRKPRHLYVS MPTAQSTMKA DEITPGRFRT IACGLFPAQV KARNIISPVM GVIGFSFFVK DWMERIDDFL AARCPFLPEQ KDPRDAALAT NRAYFITRQL QVDESKVSDI EDLIADARAE SATIFADIAT PHSVWVFACA PDRCPPTALY VAGMPELGAF FAILQDMRNT IMASKSVGTS EEKLKKKSAF YQSYLRRTQS MGIQLDQKII ILYMSHWGRE AVNHFHLGDD MDPELRELAQ TLVDIKVREI SNQEPLKL //