ID Q88009_SIV Unreviewed; 876 AA. AC Q88009; DT 01-NOV-1996, integrated into UniProtKB/TrEMBL. DT 01-NOV-1996, sequence version 1. DT 01-APR-2015, entry version 81. DE RecName: Full=Envelope glycoprotein gp160 {ECO:0000256|SAAS:SAAS00139992}; DE Flags: Fragment; GN Name=env {ECO:0000313|EMBL:AAA47620.1}; OS Simian immunodeficiency virus (SIV). OC Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; OC Lentivirus; Primate lentivirus group. OX NCBI_TaxID=11723 {ECO:0000313|EMBL:AAA47620.1}; OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee). RN [1] {ECO:0000313|EMBL:AAA47620.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=8411355; RA Kodama T., Mori K., Kawahara T., Ringler D.J., Desrosiers R.C.; RT "Analysis of simian immunodeficiency virus sequence variation in RT tissues of rhesus macaques with simian AIDS."; RL J. Virol. 67:6522-6534(1993). CC -!- SUBCELLULAR LOCATION: Virion membrane CC {ECO:0000256|SAAS:SAAS00140070}; Single-pass type I membrane CC protein {ECO:0000256|SAAS:SAAS00140070}. Host cell membrane CC {ECO:0000256|SAAS:SAAS00140070}; Single-pass type I membrane CC protein {ECO:0000256|SAAS:SAAS00140070}. Host endosome membrane CC {ECO:0000256|SAAS:SAAS00140070}; Single-pass type I membrane CC protein {ECO:0000256|SAAS:SAAS00140070}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L22813; AAA47620.1; -; Genomic_DNA. DR PIR; A47665; A47665. DR PIR; C47665; C47665. DR ProteinModelPortal; Q88009; -. DR GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell. DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW. DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro. DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. DR GO; GO:0039663; P:membrane fusion involved in viral entry into host cell; IEA:UniProtKB-KW. DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW. DR Gene3D; 2.170.40.20; -; 2. DR InterPro; IPR000777; HIV1_GP160. DR InterPro; IPR000328; Retroviral_envelope_protein. DR Pfam; PF00516; GP120; 1. DR Pfam; PF00517; GP41; 1. DR SUPFAM; SSF56502; SSF56502; 3. PE 4: Predicted; KW Apoptosis {ECO:0000256|SAAS:SAAS00140089}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00132312}; KW Fusion of virus membrane with host membrane KW {ECO:0000256|SAAS:SAAS00132404}; KW Host endosome {ECO:0000256|SAAS:SAAS00139996}; KW Host-virus interaction {ECO:0000256|SAAS:SAAS00132180}; KW Membrane {ECO:0000256|SAAS:SAAS00193006}; KW Viral attachment to host cell {ECO:0000256|SAAS:SAAS00131527}; KW Viral envelope protein {ECO:0000313|EMBL:AAA47620.1}; KW Viral penetration into host cytoplasm {ECO:0000256|SAAS:SAAS00132213}; KW Virion {ECO:0000256|SAAS:SAAS00193037}; KW Virus entry into host cell {ECO:0000256|SAAS:SAAS00132354}. FT NON_TER 1 1 {ECO:0000313|EMBL:AAA47620.1}. FT NON_TER 876 876 {ECO:0000313|EMBL:AAA47620.1}. SQ SEQUENCE 876 AA; 101036 MW; C89115886275B1F5 CRC64; IGCLRNQLLI AILLLSVYRI YCTLYVTVFY GVPAWRNATI PLFCATKNRD TWGTTQCLPD NSDYSEMALN VTESFDAWNN TVTEQAIEDV WQLFETSIKP CVKLSPLCIT MRCNKSETDR WRLTKSITTT ASTTSTTASA KVDMVDETSS CIAQDNYAGL EQEQMISCKF NMTGLERDKK KKYNETWYSA DLVCEQGNNT GNESRCYMNH CNTSVIQESC DKHYWDAIRF RYCAPPGYAL LRCNDTNYSG FMPKCSKVVV SSCTRMMETQ ASTWFGFNGT RAENRTYIYW HGRDNRTIIS LNKYYNLTMK CRRPGNKTVS PVTIMSGLVF HSQPINDRPK QAWCRFGGKW KDAIKEVKQT IVKHPRYTGT NNTDKINLTA PRGGNPEATF MWTNCRGEFL YCKMNWFLNW VEDRNTANQK LKEQHKRNYV PCHIRQIINT WHKVGKNVYL PPREGDLTCN STVTSLIANI DWIDGNQTNI TMSAEVAELY RLELGDYKLV EITPIGLAPT DVKRYTTGGT SRNKRGVFVL GFLGFLATAG SAMGAASLTL TAQSRTLLAG IVQQQQQLLD VVKRQQELLR LTVWGTKNLQ TRVTAIEKYL KDQAQLNAWG CAFRQVCHTT VPWPNASLTP KWNNETWQEW ERKVDFLEEN ITALLEEAQI QQEKNMYELQ KLNSWDVFGN WFDLSSWIKY IQYGVYIVVG VILLRIVIYI VQMLAKLRQG YRPVFSSPPS YFQQTHIQQD PALPTREGKE RDGGEGGGNS SWPWQIEYIH FLIRQLIRLL TWLFSNCRTL LSRVYQILQP ILQRLSATLQ RIREVLRTEL TYLQYGWSYF HEAVQAVWRS ATETLAGAWG DLWETLRRGG RWILAIPRRI RQGLEL //