ID Q88009_SIV Unreviewed; 876 AA. AC Q88009; DT 01-NOV-1996, integrated into UniProtKB/TrEMBL. DT 01-NOV-1996, sequence version 1. DT 09-JAN-2013, entry version 69. DE SubName: Full=Envelope glycoprotein; DE Flags: Fragment; GN Name=env; OS Simian immunodeficiency virus (SIV). OC Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; OC Lentivirus; Primate lentivirus group. OX NCBI_TaxID=11723; OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee). RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=94016835; PubMed=8411355; RA Kodama T., Mori K., Kawahara T., Ringler D.J., Desrosiers R.C.; RT "Analysis of simian immunodeficiency virus sequence variation in RT tissues of rhesus macaques with simian AIDS."; RL J. Virol. 67:6522-6534(1993). CC -!- FUNCTION: The envelope glyprotein gp160 precursor down-modulates CC cell surface CD4 antigen by interacting with it in the endoplasmic CC reticulum and blocking its transport to the cell surface (By CC similarity). CC -!- FUNCTION: The gp120-gp41 heterodimer allows rapid transcytosis of CC the virus through CD4 negative cells such as simple epithelial CC monolayers of the intestinal, rectal and endocervical epithelial CC barriers. Both gp120 and gp41 specifically recognize CC glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo- CC galactosyl-ceramide (GalS) present in the lipid rafts structures CC of epithelial cells. Binding to these alternative receptors allows CC the rapid transcytosis of the virus through the epithelial cells. CC This transcytotic vesicle-mediated transport of virions from the CC apical side to the basolateral side of the epithelial cells does CC not involve infection of the cells themselves (By similarity). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L22813; AAA47620.1; -; Genomic_DNA. DR PIR; A47665; A47665. DR PIR; C47665; C47665. DR HSSP; Q88007; 1QBZ. DR ProteinModelPortal; Q88009; -. DR GO; GO:0044174; C:host cell endosome; IEA:UniProtKB-KW. DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-KW. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW. DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro. DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. DR GO; GO:0019062; P:viral attachment to host cell; IEA:UniProtKB-KW. DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW. DR Gene3D; 2.170.40.20; GP120; 2. DR InterPro; IPR000777; HIV1_GP160. DR InterPro; IPR000328; Retroviral_envelope_protein. DR Pfam; PF00516; GP120; 1. DR Pfam; PF00517; GP41; 1. DR SUPFAM; SSF56502; GP120; 1. PE 3: Inferred from homology; KW Apoptosis; Disulfide bond; KW Fusion of virus membrane with host membrane; Host cell membrane; KW Host endosome; Host membrane; Host-virus interaction; Membrane; KW Transmembrane; Transmembrane helix; Viral attachment to host cell; KW Viral envelope protein; Viral penetration into host cytoplasm; Virion; KW Virus entry into host cell. FT NON_TER 1 1 FT NON_TER 876 876 SQ SEQUENCE 876 AA; 101036 MW; C89115886275B1F5 CRC64; IGCLRNQLLI AILLLSVYRI YCTLYVTVFY GVPAWRNATI PLFCATKNRD TWGTTQCLPD NSDYSEMALN VTESFDAWNN TVTEQAIEDV WQLFETSIKP CVKLSPLCIT MRCNKSETDR WRLTKSITTT ASTTSTTASA KVDMVDETSS CIAQDNYAGL EQEQMISCKF NMTGLERDKK KKYNETWYSA DLVCEQGNNT GNESRCYMNH CNTSVIQESC DKHYWDAIRF RYCAPPGYAL LRCNDTNYSG FMPKCSKVVV SSCTRMMETQ ASTWFGFNGT RAENRTYIYW HGRDNRTIIS LNKYYNLTMK CRRPGNKTVS PVTIMSGLVF HSQPINDRPK QAWCRFGGKW KDAIKEVKQT IVKHPRYTGT NNTDKINLTA PRGGNPEATF MWTNCRGEFL YCKMNWFLNW VEDRNTANQK LKEQHKRNYV PCHIRQIINT WHKVGKNVYL PPREGDLTCN STVTSLIANI DWIDGNQTNI TMSAEVAELY RLELGDYKLV EITPIGLAPT DVKRYTTGGT SRNKRGVFVL GFLGFLATAG SAMGAASLTL TAQSRTLLAG IVQQQQQLLD VVKRQQELLR LTVWGTKNLQ TRVTAIEKYL KDQAQLNAWG CAFRQVCHTT VPWPNASLTP KWNNETWQEW ERKVDFLEEN ITALLEEAQI QQEKNMYELQ KLNSWDVFGN WFDLSSWIKY IQYGVYIVVG VILLRIVIYI VQMLAKLRQG YRPVFSSPPS YFQQTHIQQD PALPTREGKE RDGGEGGGNS SWPWQIEYIH FLIRQLIRLL TWLFSNCRTL LSRVYQILQP ILQRLSATLQ RIREVLRTEL TYLQYGWSYF HEAVQAVWRS ATETLAGAWG DLWETLRRGG RWILAIPRRI RQGLEL //