ID Q88009_SIVCZ Unreviewed; 876 AA. AC Q88009; DT 01-NOV-1996, integrated into UniProtKB/TrEMBL. DT 01-NOV-1996, sequence version 1. DT 11-SEP-2007, entry version 38. DE Envelope glycoprotein (Fragment). GN Name=env; OS Simian immunodeficiency virus (isolate CPZ GAB1) (SIV-cpz) (Chimpanzee OS immunodeficiency virus). OC Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; OC Lentivirus; Primate lentivirus group. OX NCBI_TaxID=11723; OH NCBI_TaxID=9596; Pan (chimpanzees). RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=94016835; PubMed=8411355; RA Kodama T., Mori K., Kawahara T., Ringler D.J., Desrosiers R.C.; RT "Analysis of simian immunodeficiency virus sequence variation in RT tissues of rhesus macaques with simian AIDS."; RL J. Virol. 67:6522-6534(1993). CC -!- FUNCTION: Allows rapid transcytosis of the virus through CD4 CC negative cells such as simple epithelial monolayers of the CC intestinal, rectal and endocervical epithelial barriers. Both CC gp120 and gp41 specifically recognize glycosphingolipids CC galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide CC (GalS) present in the lipid rafts structures of epithelial cells. CC Binding to these alternative receptors allows the rapid CC transcytosis of the virus through the epithelial cells. This CC transcytotic vesicle-mediated transport of virions from the apical CC side to the basolateral side of the epithelial cells does not CC involve infection of the cells themselves (By similarity). CC -!- FUNCTION: The transmembrane protein gp41 (TM) acts as a class I CC viral fusion protein. Under the current model, the protein has at CC least 3 conformational states: pre-fusion native state, pre- CC hairpin intermediate state, and post-fusion hairpin state. During CC viral and target cell membrane fusion, the coiled coil regions CC (heptad repeats) assume a trimer-of-hairpins structure, CC positioning the fusion peptide in close proximity to the C- CC terminal region of the ectodomain. The formation of this structure CC appears to drive apposition and subsequent fusion of viral and CC target cell membranes. Membranes fusion leads to delivery of the CC nucleocapsid into the cytoplasm (By similarity). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L22813; AAA47620.1; -; Genomic_DNA. DR PIR; A47665; A47665. DR PIR; C47665; C47665. DR HSSP; Q88007; 1QBZ. DR SMR; Q88009; 64-116, 553-674. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0019031; C:viral envelope; IEA:InterPro. DR InterPro; IPR000328; Env_GP41. DR InterPro; IPR000777; GP120. DR Gene3D; G3DSA:2.170.40.20; GP120; 1. DR Pfam; PF00516; GP120; 1. DR Pfam; PF00517; GP41; 1. PE 3: Inferred from homology; KW Apoptosis; Coiled coil; Envelope protein; Fusion protein; KW Host-virus interaction; Membrane; Transmembrane; Virion. FT NON_TER 1 1 FT NON_TER 876 876 SQ SEQUENCE 876 AA; 101036 MW; C89115886275B1F5 CRC64; IGCLRNQLLI AILLLSVYRI YCTLYVTVFY GVPAWRNATI PLFCATKNRD TWGTTQCLPD NSDYSEMALN VTESFDAWNN TVTEQAIEDV WQLFETSIKP CVKLSPLCIT MRCNKSETDR WRLTKSITTT ASTTSTTASA KVDMVDETSS CIAQDNYAGL EQEQMISCKF NMTGLERDKK KKYNETWYSA DLVCEQGNNT GNESRCYMNH CNTSVIQESC DKHYWDAIRF RYCAPPGYAL LRCNDTNYSG FMPKCSKVVV SSCTRMMETQ ASTWFGFNGT RAENRTYIYW HGRDNRTIIS LNKYYNLTMK CRRPGNKTVS PVTIMSGLVF HSQPINDRPK QAWCRFGGKW KDAIKEVKQT IVKHPRYTGT NNTDKINLTA PRGGNPEATF MWTNCRGEFL YCKMNWFLNW VEDRNTANQK LKEQHKRNYV PCHIRQIINT WHKVGKNVYL PPREGDLTCN STVTSLIANI DWIDGNQTNI TMSAEVAELY RLELGDYKLV EITPIGLAPT DVKRYTTGGT SRNKRGVFVL GFLGFLATAG SAMGAASLTL TAQSRTLLAG IVQQQQQLLD VVKRQQELLR LTVWGTKNLQ TRVTAIEKYL KDQAQLNAWG CAFRQVCHTT VPWPNASLTP KWNNETWQEW ERKVDFLEEN ITALLEEAQI QQEKNMYELQ KLNSWDVFGN WFDLSSWIKY IQYGVYIVVG VILLRIVIYI VQMLAKLRQG YRPVFSSPPS YFQQTHIQQD PALPTREGKE RDGGEGGGNS SWPWQIEYIH FLIRQLIRLL TWLFSNCRTL LSRVYQILQP ILQRLSATLQ RIREVLRTEL TYLQYGWSYF HEAVQAVWRS ATETLAGAWG DLWETLRRGG RWILAIPRRI RQGLEL //