ID   UVRA_XYLFT              Reviewed;         965 AA.
AC   Q87BK9;
DT   16-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   16-JUN-2003, sequence version 1.
DT   11-MAY-2016, entry version 93.
DE   RecName: Full=UvrABC system protein A {ECO:0000255|HAMAP-Rule:MF_00205};
DE            Short=UvrA protein {ECO:0000255|HAMAP-Rule:MF_00205};
DE   AltName: Full=Excinuclease ABC subunit A {ECO:0000255|HAMAP-Rule:MF_00205};
GN   Name=uvrA {ECO:0000255|HAMAP-Rule:MF_00205};
GN   OrderedLocusNames=PD_1444;
OS   Xylella fastidiosa (strain Temecula1 / ATCC 700964).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales;
OC   Xanthomonadaceae; Xylella.
OX   NCBI_TaxID=183190;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Temecula1 / ATCC 700964;
RX   PubMed=12533478; DOI=10.1128/JB.185.3.1018-1026.2003;
RA   Van Sluys M.A., de Oliveira M.C., Monteiro-Vitorello C.B.,
RA   Miyaki C.Y., Furlan L.R., Camargo L.E.A., da Silva A.C.R., Moon D.H.,
RA   Takita M.A., Lemos E.G.M., Machado M.A., Ferro M.I.T., da Silva F.R.,
RA   Goldman M.H.S., Goldman G.H., Lemos M.V.F., El-Dorry H., Tsai S.M.,
RA   Carrer H., Carraro D.M., de Oliveira R.C., Nunes L.R., Siqueira W.J.,
RA   Coutinho L.L., Kimura E.T., Ferro E.S., Harakava R., Kuramae E.E.,
RA   Marino C.L., Giglioti E., Abreu I.L., Alves L.M.C., do Amaral A.M.,
RA   Baia G.S., Blanco S.R., Brito M.S., Cannavan F.S., Celestino A.V.,
RA   da Cunha A.F., Fenille R.C., Ferro J.A., Formighieri E.F., Kishi L.T.,
RA   Leoni S.G., Oliveira A.R., Rosa V.E. Jr., Sassaki F.T., Sena J.A.D.,
RA   de Souza A.A., Truffi D., Tsukumo F., Yanai G.M., Zaros L.G.,
RA   Civerolo E.L., Simpson A.J.G., Almeida N.F. Jr., Setubal J.C.,
RA   Kitajima J.P.;
RT   "Comparative analyses of the complete genome sequences of Pierce's
RT   disease and citrus variegated chlorosis strains of Xylella
RT   fastidiosa.";
RL   J. Bacteriol. 185:1018-1026(2003).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrA is an ATPase and a DNA-binding
CC       protein. A damage recognition complex composed of 2 UvrA and 2
CC       UvrB subunits scans DNA for abnormalities. When the presence of a
CC       lesion has been verified by UvrB, the UvrA molecules dissociate.
CC       {ECO:0000255|HAMAP-Rule:MF_00205}.
CC   -!- SUBUNIT: Forms a heterotetramer with UvrB during the search for
CC       lesions. {ECO:0000255|HAMAP-Rule:MF_00205}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00205}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA
CC       family. {ECO:0000255|HAMAP-Rule:MF_00205}.
CC   -!- SIMILARITY: Contains 2 ABC transporter domains.
CC       {ECO:0000255|HAMAP-Rule:MF_00205}.
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DR   EMBL; AE009442; AAO29288.1; -; Genomic_DNA.
DR   RefSeq; WP_004088411.1; NC_004556.1.
DR   ProteinModelPortal; Q87BK9; -.
DR   SMR; Q87BK9; 4-942.
DR   EnsemblBacteria; AAO29288; AAO29288; PD_1444.
DR   KEGG; xft:PD1444; -.
DR   PATRIC; 24151084; VBIXylFas71109_1846.
DR   KO; K03701; -.
DR   OMA; GAIKGWD; -.
DR   OrthoDB; EOG6QK4PS; -.
DR   BioCyc; XFAS183190:GIX4-1444-MONOMER; -.
DR   Proteomes; UP000002516; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0016887; F:ATPase activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-HAMAP.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-HAMAP.
DR   Gene3D; 3.30.1490.20; -; 2.
DR   Gene3D; 3.40.50.300; -; 4.
DR   HAMAP; MF_00205; UvrA; 1.
DR   InterPro; IPR003439; ABC_transporter-like.
DR   InterPro; IPR017871; ABC_transporter_CS.
DR   InterPro; IPR013815; ATP_grasp_subdomain_1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR004602; UvrA.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SUPFAM; SSF52540; SSF52540; 3.
DR   TIGRFAMs; TIGR00630; uvra; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA damage; DNA excision;
KW   DNA repair; DNA-binding; Excision nuclease; Metal-binding;
KW   Nucleotide-binding; Repeat; SOS response; Zinc; Zinc-finger.
FT   CHAIN         1    965       UvrABC system protein A.
FT                                /FTId=PRO_0000093119.
FT   DOMAIN      311    588       ABC transporter 1. {ECO:0000255|HAMAP-
FT                                Rule:MF_00205}.
FT   DOMAIN      608    937       ABC transporter 2. {ECO:0000255|HAMAP-
FT                                Rule:MF_00205}.
FT   NP_BIND      32     39       ATP. {ECO:0000255|HAMAP-Rule:MF_00205}.
FT   ZN_FING     254    281       C4-type. {ECO:0000255|HAMAP-
FT                                Rule:MF_00205}.
FT   NP_BIND     641    648       ATP. {ECO:0000255|HAMAP-Rule:MF_00205}.
FT   ZN_FING     740    766       C4-type. {ECO:0000255|HAMAP-
FT                                Rule:MF_00205}.
SQ   SEQUENCE   965 AA;  106939 MW;  2C56691CDF7D506B CRC64;
     MTALIRIRGA RTHNLKNLDL DLPRNTLIVI TGLSGSGKSS LAFDTIYAEG QRRYVESLSA
     YARQFLSVME KPDVDHIEGL SPAISIEQKS TSHNPRSTVG TITEIYDYLR LLYARVGQPR
     CPEHHYPLEA QTVSQMVDHV LTLDPEQRYM LLAPVVRERK GEHTQVFEQL RAQGFVRVRV
     DGELYEIDAV PTLTLRQKHT IEAVIDRFRP REDIKQRLAE SFETALKLGN GMASVQTLDT
     TTATPHLFSS KYSCPVCDYS LPELEPRLFS FNAPMGACPA CNGLGVTEFF DPAKVVIHPD
     LSLSAGAVRG WDRRNAYYFQ LIASLAKHYT FDIDASWESL PEEIRHTILF GSGDEQINFT
     YLTEAGGRTK RKHRFEGIVP NLERRYRETE SAAVREELAK YVSTRTCPEC GGTRLNRAAR
     NVFVADRTLP ELTVLPINDA LEFFKTLRLS GWRGEIAIKI VKEIGERLGF LVDVGLDYLT
     LERKADTLSG GEAQRIRLAS QIGAGLVGVM YVLDEPSIGL HQRDNERLLG TLTRLRDLGN
     TVIVVEHDED AIRQADHILD IGPGAGVHGG EICAQGSLEQ IMAAPRSLTG QYLSGRRRIE
     IPKQRHPPNA TKMLHLRGAC GNNLKGVNLD IPEGLFTCIT GVSGSGKSTL INDTLFTLAA
     NEINGASHPI APYASVDGLE LFDKVVDIDQ SPIGRTPRSN PATYTGMFTP LRELFAQVPE
     ARARGYSPGR FSFNVRGGRC EACEGDGLIK VEMHFLPDVY VPCDICHGKR YNRETLEIRY
     KGYNINDVLE MTVEDALKLF EAVPAIARKL ETLVDVGLSY LKLGQSATTL SGGEAQRVKL
     SKELSRRDTG HTLYILDEPT TGLHFYDIEA LLAVMHKLRD AGNTVIVIEH NLDVIKTADW
     VIDLGPEGGG RGGEILVAGT PETVAAHPHS HTGHFLAKLL PPKDVSNCGH RNPKEEVDIA
     KTVHR
//