ID MYO2_SACKL STANDARD; PRT; 1554 AA. AC Q875Q8; DT 01-FEB-2005 (Rel. 46, Created) DT 01-FEB-2005 (Rel. 46, Last sequence update) DT 01-MAY-2005 (Rel. 47, Last annotation update) DE Myosin-2 (Class V unconventional myosin MYO2) (Type V myosin heavy DE chain MYO2) (Myosin V MYO2). GN Name=MYO2; OS Saccharomyces kluyveri (Yeast). OC Eukaryota; Fungi; Ascomycota; Saccharomycotina; Saccharomycetes; OC Saccharomycetales; Saccharomycetaceae; Saccharomyces. OX NCBI_TaxID=4934; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=CBS 3082; RX MEDLINE=22482865; PubMed=12594514; DOI=10.1038/nature01419; RA Langkjaer R.B., Cliften P.F., Johnston M., Piskur J.; RT "Yeast genome duplication was followed by asynchronous differentiation RT of duplicated genes."; RL Nature 421:848-852(2003). CC -!- FUNCTION: Myosin heavy chain that is required for the cell cycle- CC regulated transport of various organelles and proteins for their CC segregation. Functions by binding with its tail domain to receptor CC proteins on organelles and exerting force with its N-terminal CC motor domain against actin filaments, thereby transporting its CC cargo along polarized actin cables (By similarity). CC -!- SUBUNIT: Homodimer. Interacts with calmodulin (CMD1) and the CC myosin light chain MLC1 through its IQ repeats (By similarity). CC -!- SIMILARITY: Contains 1 dilute domain. CC -!- SIMILARITY: Contains 6 IQ domains. CC -!- SIMILARITY: Contains 1 myosin-like globular head domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY145011; AAO32574.1; -. DR HSSP; P08799; 1MND. DR InterPro; IPR002710; DIL. DR InterPro; IPR000048; IQ_region. DR InterPro; IPR001609; Myosin_head. DR InterPro; IPR004009; Myosin_N. DR InterPro; IPR008989; Myosin_S1_N. DR Pfam; PF01843; DIL; 1. DR Pfam; PF00612; IQ; 5. DR Pfam; PF00063; Myosin_head; 1. DR Pfam; PF02736; Myosin_N; 1. DR PRINTS; PR00193; MYOSINHEAVY. DR ProDom; PD003376; DIL; 1. DR ProDom; PD000355; Myosin_head; 1. DR SMART; SM00015; IQ; 5. DR SMART; SM00242; MYSc; 1. DR PROSITE; PS50096; IQ; 3. KW Actin-binding; ATP-binding; Cell cycle; Coiled coil; Motor protein; KW Multigene family; Myosin; Protein transport; Repeat; Transport. FT DOMAIN 72 762 Myosin head-like. FT NP_BIND 164 171 ATP (Potential). FT DOMAIN 443 523 Actin-binding (By similarity). FT DOMAIN 778 798 IQ 1. FT DOMAIN 800 824 IQ 2. FT DOMAIN 825 847 IQ 3. FT DOMAIN 848 872 IQ 4. FT DOMAIN 873 895 IQ 5. FT DOMAIN 896 925 IQ 6. FT DOMAIN 926 1079 Coiled coil (Potential). FT DOMAIN 1080 1554 Non alpha-helical, tail domain. FT DOMAIN 1360 1463 Dilute. SQ SEQUENCE 1554 AA; 178198 MW; 412A25F7A4C3A8FD CRC64; MSYEVGTRCW YPDKQQGWIG GEITKHTNLS NKHQLELTLE DNQIVEIESE TLDETKDDRL PLLRNPPILE ATEDLTSLSY LNEPAVLHAI KARYAQLNIY TYSGIVLIAT NPFDRVEQLY SQDMIQAYAG KRRGELEPHL FAIAEEAYRL MKNDKQNQTI VVSGESGAGK TVSAKYIMRY FASVEQNNEE NAHHNLEMSE TEKKILATNP IMEAFGNAKT TRNDNSSRFG KYLEILFDKE ISIIGARIRT YLLERSRLVF QPKSERNYHI FYQLLAGLTN EEKSQLKLTG VEDYHYMNQG GEAQIKGIDD AEEYQTTVEA LSLVGISKDT QYQLFKILAA LLHIGNVEIK KTRNDASLSS DEPNLAIACE LLGIDSFNFA KWITKKQINT RSEKIVSNLN YNQALVARDS VAKFIYSALF EWLVDNINTV LCNPEVASEI NSFIGVLDIY GFEHFEKNSF EQFCINYANE KLQQEFNQHV FKLEQEEYVK EEIEWSFIEF NDNQPCIDLI ENKLGILSLL DEESRLPAGS DETWTQKLYQ TLDKPPTNTV FSKPRFGQTK FVVSHYALDV SYDVEGFIEK NRDTVSDGHL EVLKASTNET LLSILETLDK HAAKLAEKEQ VNKKPGPARM VNRKPTLGSI FKQSLIELMG TINSTNVHYI RCIKPNEVKE AWVFDNLMVL SQLRACGVLE TIRISCAGFP SRWTYNEFVL RYHILIPSEH WSKMFSSDTT EEDIRDLCRT ILGAIVEDKQ KYQLGNTKIF FKAGMLAYLE KLRSDRLHNS SVLIQKKVKA VYYRKKYLAI ISSIRNFHSR SEGFLTRQRV DLEFKTQAAI LIQSMVRSTS TRNKTISLLS AITRLQSLVR KQLAQKELLQ RRQRDAAVSI QKKIRAFEPR QSFNTTRRST VVVQSLVRKK FAQKKLKDLK TEAKSVNHLK EVSYKLENKV IQLTESLAEK VKENKGMTAR IQELQQSLNE SANIKELLNS QKDEHSKVLQ QQKDAHDVQF NEVQEKLVNA KKEVEEAKEE IEQLIAKQDE LKAEVRTKIE ELNKAKKTFT EFQTQNSDLK NEVKSLKDEI ARLQAAVRSG VTSSTITSTP TASRRFSAHS SVADGTSPRQ LNVISMNNGG IEDDARSTAS ALSQINDELY KLLEDTKSLN TEIVEGLLKG FKIPETGVAV ELTRKEVLYP ARILIIVLSD MWRLGLTKQS ESFLAEVLST IQKLVTNLKG DDMILHGAFW LTNVRELYSF VVFAQESILN DDSYNNGLNE DEYKEYVTLV TELKDDFESL SYNIYNIWLK KLQKDLERKA ISAVVMSQSL PGFIAPESSP FLPKLFSQSS HYKMDDILTF FNNIYWSMKT YHVETEVFRE VIMTLLKYVD AICFNDLIMR RNFLSWKRGL QLNYNVTRLE EWCKSHQLPE GTECLQHMLQ ASKLLQLKKA NLEDINIIWE ICSSLKPAQI QKLISQYAVA DYEVPIPQEI LNFVADRVKK ESSLSSDGKS QTHSSDIFLS VDSGPFEDPF GQIETREFGK IEAYIPAWLN LPITRRVVEL VTQHVTVQES QRTE //