ID Q86YY1_HUMAN Unreviewed; 959 AA. AC Q86YY1; DT 01-JUN-2003, integrated into UniProtKB/TrEMBL. DT 01-JUN-2003, sequence version 1. DT 29-MAY-2024, entry version 64. DE RecName: Full=Nuclear receptor corepressor 1 {ECO:0000256|ARBA:ARBA00044171}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:AAO32941.1}; RN [1] {ECO:0000313|EMBL:AAO32941.1} RP NUCLEOTIDE SEQUENCE. RA Yu L.; RL Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the N-CoR nuclear receptor corepressors family. CC {ECO:0000256|ARBA:ARBA00010097}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF303585; AAO32941.1; -; mRNA. DR PDBsum; 6ONI; -. DR AlphaFoldDB; Q86YY1; -. DR PeptideAtlas; Q86YY1; -. DR GO; GO:0046966; F:nuclear thyroid hormone receptor binding; IEA:TreeGrafter. DR GO; GO:0003714; F:transcription corepressor activity; IEA:TreeGrafter. DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:TreeGrafter. DR PANTHER; PTHR13992; NUCLEAR RECEPTOR CO-REPRESSOR RELATED NCOR; 1. DR PANTHER; PTHR13992:SF5; NUCLEAR RECEPTOR COREPRESSOR 1; 1. PE 2: Evidence at transcript level; FT REGION 33..58 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 211..279 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 404..442 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 463..489 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 526..561 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 587..675 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 807..959 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 33..50 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 229..252 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 427..442 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 473..487 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 540..560 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 587..636 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 648..662 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 866..880 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 890..935 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 959 AA; 104500 MW; 35F97ED97CFB1CDD CRC64; MVEKWTNIII LASFLRTCGI GSFFPVTISS NKSTNHERKS TLTPTQRESI PAKSPVPGVD PVVSHSPFDP HHRGSTAGEV YRSHLPTHLD PAMPFHRALD PAAAYLFQRQ LSPTPGYPSQ YQLYAMENTR QTILNDYITS QQMQVNLRPD VARGLSPREQ PLGLPYPATR GIIDLTNMPP TILVPHPGGT STPPMDRITY IPGTQITFPP RPYNSASMSP GHPTHLAAAA SAERERERER EKERERERIA AASSDLYLRP GSEQPGRPGS HGYVRSPSPS VRTQETMLQQ RPSVFQGTNG TSVITPLDPT AQLRIMPLPA GGPSISQGLP ASRYNTAADA LAALVDAAAS APQMDVSKTK ESKHEAARLE ENLRSRSAAV SEQQQLEQKT LEVEKRSVQC LYTSSAFPSG KPQPHSSVVY SEAGKDKGPP PKSRYEEELR TRGKTTITAA NFIDVIITRQ IASDKDARER GSQSSDSSSS LSSHRYETPS DAIEVISPAS SPAPPQEKLQ TYQPEVVKAN QAENDPTRQY EGPLHHYRPQ QESPSPQQQL PPSSQAEGMG QVPRTHRLIT LADHICQIIT QDFARNQVSS QTPQQPPTST FQNSPSALVS TPVRTKTSNR YSPESQAQSV HHQRPGSRVS PENLVDKSRG SRPGKSPERS HVSSEPYEPI SPPQVPVVHE KQDSLLLLSQ RGAEPAEQRN DARSPGSISY LPSFFTKLEN TSPMVKSKKQ EIFRKLNSSG GGDSDMAAAQ PGTEIFNLPA VTTSGSVSSR GHSFADPASN LGLEDIIRKA LMGSFDDKVE DHGVVMSQPM GVVPGTANTS VVTSGETRRE EGDPSPHSGV CKPKLISKSN SRKSKSPIPG QGYLGTERPS SVSSVHSEGD YHRQTPGWAW EDRPSSTGST QFPYNPLTMR MLSSTPPTPI ACAPSAVNQA APHQQNRIWE REPAPLLSAQ YETLSDSDD //