ID PTH_HUMAN Reviewed; 214 AA. AC Q86Y79; DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-2003, sequence version 1. DT 19-JAN-2010, entry version 58. DE RecName: Full=Probable peptidyl-tRNA hydrolase; DE Short=PTH; DE EC=3.1.1.29; GN Name=PTRH1; Synonyms=C9orf115; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Placenta; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- CATALYTIC ACTIVITY: N-substituted aminoacyl-tRNA + H(2)O = N- CC substituted amino acid + tRNA. CC -!- SIMILARITY: Belongs to the PTH family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC047012; AAH47012.1; -; mRNA. DR IPI; IPI00048572; -. DR RefSeq; NP_001002913.1; -. DR UniGene; Hs.653265; -. DR SMR; Q86Y79; 29-205. DR STRING; Q86Y79; -. DR PRIDE; Q86Y79; -. DR Ensembl; ENST00000419060; ENSP00000418661; ENSG00000187024; Homo sapiens. DR GeneID; 138428; -. DR KEGG; hsa:138428; -. DR UCSC; uc004bro.1; human. DR CTD; 138428; -. DR GeneCards; GC09M129516; -. DR HGNC; HGNC:27039; PTRH1. DR HPA; HPA021223; -. DR eggNOG; prNOG18593; -. DR HOVERGEN; Q86Y79; -. DR InParanoid; Q86Y79; -. DR PhylomeDB; Q86Y79; -. DR BRENDA; 3.1.1.29; 247. DR NextBio; 83788; -. DR CleanEx; HS_PTRH1; -. DR Genevestigator; Q86Y79; -. DR GermOnline; ENSG00000187024; Homo sapiens. DR GO; GO:0004045; F:aminoacyl-tRNA hydrolase activity; IEA:EC. DR GO; GO:0006412; P:translation; IEA:InterPro. DR InterPro; IPR001328; Pept_tRNA_hydro. DR InterPro; IPR018171; Pept_tRNA_hydro_CS. DR Gene3D; G3DSA:3.40.50.1470; Pept_tRNA_hydro; 1. DR PANTHER; PTHR17224; Pept_tRNA_hydro; 1. DR Pfam; PF01195; Pept_tRNA_hydro; 1. DR PROSITE; PS01195; PEPT_TRNA_HYDROL_1; FALSE_NEG. DR PROSITE; PS01196; PEPT_TRNA_HYDROL_2; 1. PE 2: Evidence at transcript level; KW Complete proteome; Hydrolase. FT CHAIN 1 214 Probable peptidyl-tRNA hydrolase. FT /FTId=PRO_0000240441. SQ SEQUENCE 214 AA; 22937 MW; DBA3959411DA8248 CRC64; MRPGGFLGAG QRLSRAMSRC VLEPRPPGKR WMVAGLGNPG LPGTRHSVGM AVLGQLARRL GVAESWTRDR HCAADLALAP LGDAQLVLLR PRRLMNANGR SVARAAELFG LTAEEVYLVH DELDKPLGRL ALKLGGSARG HNGVRSCISC LNSNAMPRLR VGIGRPAHPE AVQAHVLGCF SPAEQELLPL LLDRATDLIL DHIRERSQGP SLGP //