ID PTH_HUMAN Reviewed; 214 AA. AC Q86Y79; DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-2003, sequence version 1. DT 10-FEB-2021, entry version 136. DE RecName: Full=Probable peptidyl-tRNA hydrolase; DE Short=PTH; DE EC=3.1.1.29; GN Name=PTRH1; Synonyms=C9orf115; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Placenta; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- CATALYTIC ACTIVITY: CC Reaction=H2O + N-acyl-L-alpha-aminoacyl-tRNA = an N-acyl-L-amino acid + CC H(+) + tRNA; Xref=Rhea:RHEA:54448, Rhea:RHEA-COMP:10123, Rhea:RHEA- CC COMP:13883, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:59874, CC ChEBI:CHEBI:78442, ChEBI:CHEBI:138191; EC=3.1.1.29; CC -!- INTERACTION: CC Q86Y79; O15084: ANKRD28; NbExp=3; IntAct=EBI-2602515, EBI-359567; CC Q86Y79; Q8IZU0: FAM9B; NbExp=3; IntAct=EBI-2602515, EBI-10175124; CC Q86Y79; P80188: LCN2; NbExp=3; IntAct=EBI-2602515, EBI-11911016; CC Q86Y79; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-2602515, EBI-79165; CC -!- SIMILARITY: Belongs to the PTH family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC047012; AAH47012.1; -; mRNA. DR CCDS; CCDS35147.1; -. DR RefSeq; NP_001002913.1; NM_001002913.2. DR SMR; Q86Y79; -. DR BioGRID; 126512; 8. DR IntAct; Q86Y79; 7. DR STRING; 9606.ENSP00000418661; -. DR iPTMnet; Q86Y79; -. DR PhosphoSitePlus; Q86Y79; -. DR BioMuta; PTRH1; -. DR DMDM; 74750555; -. DR EPD; Q86Y79; -. DR jPOST; Q86Y79; -. DR MassIVE; Q86Y79; -. DR MaxQB; Q86Y79; -. DR PaxDb; Q86Y79; -. DR PeptideAtlas; Q86Y79; -. DR PRIDE; Q86Y79; -. DR ProteomicsDB; 70381; -. DR Antibodypedia; 17102; 105 antibodies. DR DNASU; 138428; -. DR Ensembl; ENST00000419060; ENSP00000418661; ENSG00000187024. DR Ensembl; ENST00000543175; ENSP00000439469; ENSG00000187024. DR GeneID; 138428; -. DR KEGG; hsa:138428; -. DR UCSC; uc004bro.4; human. DR CTD; 138428; -. DR DisGeNET; 138428; -. DR GeneCards; PTRH1; -. DR HGNC; HGNC:27039; PTRH1. DR HPA; ENSG00000187024; Low tissue specificity. DR neXtProt; NX_Q86Y79; -. DR OpenTargets; ENSG00000187024; -. DR PharmGKB; PA134917129; -. DR VEuPathDB; HostDB:ENSG00000187024.13; -. DR eggNOG; KOG2255; Eukaryota. DR GeneTree; ENSGT00390000004247; -. DR InParanoid; Q86Y79; -. DR OMA; RYAHTRH; -. DR PhylomeDB; Q86Y79; -. DR TreeFam; TF332601; -. DR PathwayCommons; Q86Y79; -. DR BioGRID-ORCS; 138428; 17 hits in 874 CRISPR screens. DR ChiTaRS; PTRH1; human. DR GenomeRNAi; 138428; -. DR Pharos; Q86Y79; Tdark. DR PRO; PR:Q86Y79; -. DR Proteomes; UP000005640; Chromosome 9. DR RNAct; Q86Y79; protein. DR Bgee; ENSG00000187024; Expressed in left adrenal gland and 166 other tissues. DR ExpressionAtlas; Q86Y79; baseline and differential. DR Genevisible; Q86Y79; HS. DR GO; GO:0004045; F:aminoacyl-tRNA hydrolase activity; IBA:GO_Central. DR GO; GO:0003723; F:RNA binding; HDA:UniProtKB. DR CDD; cd00462; PTH; 1. DR Gene3D; 3.40.50.1470; -; 1. DR InterPro; IPR001328; Pept_tRNA_hydro. DR InterPro; IPR018171; Pept_tRNA_hydro_CS. DR InterPro; IPR036416; Pept_tRNA_hydro_sf. DR PANTHER; PTHR17224; PTHR17224; 1. DR Pfam; PF01195; Pept_tRNA_hydro; 1. DR SUPFAM; SSF53178; SSF53178; 1. DR PROSITE; PS01196; PEPT_TRNA_HYDROL_2; 1. PE 1: Evidence at protein level; KW Hydrolase; Reference proteome. FT CHAIN 1..214 FT /note="Probable peptidyl-tRNA hydrolase" FT /id="PRO_0000240441" SQ SEQUENCE 214 AA; 22937 MW; DBA3959411DA8248 CRC64; MRPGGFLGAG QRLSRAMSRC VLEPRPPGKR WMVAGLGNPG LPGTRHSVGM AVLGQLARRL GVAESWTRDR HCAADLALAP LGDAQLVLLR PRRLMNANGR SVARAAELFG LTAEEVYLVH DELDKPLGRL ALKLGGSARG HNGVRSCISC LNSNAMPRLR VGIGRPAHPE AVQAHVLGCF SPAEQELLPL LLDRATDLIL DHIRERSQGP SLGP //