ID   PNML1_HUMAN             Reviewed;         439 AA.
AC   Q86V59; A8K2F3; Q5U638; Q8N3H4; Q9NVE8;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 2.
DT   05-OCT-2010, entry version 52.
DE   RecName: Full=PNMA-like protein 1;
GN   Name=PNMAL1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND NUCLEOTIDE
RP   SEQUENCE [LARGE SCALE MRNA] OF 226-439 (ISOFORM 1).
RC   TISSUE=Thalamus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Amygdala;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
RA   Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
RA   Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Fetal brain, Neuroblastoma, and Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   IDENTIFICATION.
RX   PubMed=16550607; DOI=10.1002/ijc.21901;
RA   Tews B., Felsberg J., Hartmann C., Kunitz A., Hahn M., Toedt G.,
RA   Neben K., Hummerich L., von Deimling A., Reifenberger G., Lichter P.;
RT   "Identification of novel oligodendroglioma-associated candidate tumor
RT   suppressor genes in 1p36 and 19q13 using microarray-based expression
RT   profiling.";
RL   Int. J. Cancer 119:792-800(2006).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q86V59-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q86V59-2; Sequence=VSP_032441, VSP_032442;
CC       Name=3;
CC         IsoId=Q86V59-3; Sequence=VSP_032439, VSP_032440;
CC         Note=No experimental confirmation available;
CC   -!- SIMILARITY: Belongs to the PNMA family.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA91804.1; Type=Erroneous initiation;
CC       Sequence=BAF82907.1; Type=Erroneous translation; Note=Wrong choice of CDS;
CC       Sequence=EAW57420.1; Type=Erroneous initiation;
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DR   EMBL; AK001643; BAA91804.1; ALT_INIT; mRNA.
DR   EMBL; AK290218; BAF82907.1; ALT_SEQ; mRNA.
DR   EMBL; AL834344; CAD39010.1; -; mRNA.
DR   EMBL; CH471126; EAW57420.1; ALT_INIT; Genomic_DNA.
DR   EMBL; CH471126; EAW57421.1; -; Genomic_DNA.
DR   EMBL; BC026026; AAH26026.2; -; mRNA.
DR   EMBL; BC032508; AAH32508.1; -; mRNA.
DR   EMBL; BC051688; AAH51688.2; -; mRNA.
DR   IPI; IPI00328629; -.
DR   IPI; IPI00477223; -.
DR   IPI; IPI00888348; -.
DR   RefSeq; NP_001096619.1; -.
DR   RefSeq; NP_060685.2; -.
DR   UniGene; Hs.8395; -.
DR   ProteinModelPortal; Q86V59; -.
DR   STRING; Q86V59; -.
DR   Ensembl; ENST00000313683; ENSP00000318131; ENSG00000182013.
DR   GeneID; 55228; -.
DR   KEGG; hsa:55228; -.
DR   UCSC; uc002peq.2; human.
DR   UCSC; uc002per.2; human.
DR   CTD; 55228; -.
DR   GeneCards; GC19M046969; -.
DR   H-InvDB; HIX0015252; -.
DR   HGNC; HGNC:25578; PNMAL1.
DR   HPA; HPA012956; -.
DR   eggNOG; prNOG16079; -.
DR   HOGENOM; HBG126835; -.
DR   HOVERGEN; HBG108276; -.
DR   InParanoid; Q86V59; -.
DR   OMA; RSRRKKQ; -.
DR   OrthoDB; EOG9CZF29; -.
DR   NextBio; 59228; -.
DR   ArrayExpress; Q86V59; -.
DR   Bgee; Q86V59; -.
DR   CleanEx; HS_PNMAL1; -.
DR   Genevestigator; Q86V59; -.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Complete proteome; Polymorphism.
FT   CHAIN         1    439       PNMA-like protein 1.
FT                                /FTId=PRO_0000325836.
FT   VAR_SEQ     174    203       ARAQEAAEFEEMAAWALAAGRKVKKEPGLA -> GEERTGA
FT                                CSRGGFCLKGRDPQQLECHGRPA (in isoform 3).
FT                                /FTId=VSP_032439.
FT   VAR_SEQ     204    439       Missing (in isoform 3).
FT                                /FTId=VSP_032440.
FT   VAR_SEQ     367    378       VSLGPVSYVLVD -> NPERFDLGDHPY (in isoform
FT                                2).
FT                                /FTId=VSP_032441.
FT   VAR_SEQ     379    439       Missing (in isoform 2).
FT                                /FTId=VSP_032442.
FT   VARIANT      80     80       S -> T (in dbSNP:rs12610254).
FT                                /FTId=VAR_039935.
FT   VARIANT      97     97       C -> Y (in dbSNP:rs7248888).
FT                                /FTId=VAR_039936.
FT   CONFLICT    319    319       P -> S (in Ref. 4; AAH32508).
SQ   SEQUENCE   439 AA;  48161 MW;  43E43FA1CAEC1E81 CRC64;
     MSKTMAMNLL EDWCRGMEVD IHRSLLVTGI PEDCGQAEIE ETLNGVLSPL GPYRVLNKIF
     VREENVKAAL IEVGEGVNLS TIPREFPGRG GVWRVVCRDP TQDAEFLKNL NEFLDAEGRT
     WEDVVRLLQL NHPTLSQNQH QPPENWAEAL GVLLGAVVQI IFCMDAEIRS REEARAQEAA
     EFEEMAAWAL AAGRKVKKEP GLAAEVGSAL KAETPNNWNA TEDQHEPTKP LVRRAGAKSR
     SRRKKQKKNS RQEAVPWKKP KGINSNSTAN LEDPEVGDAE SMAISEPIKG SRKPCVNKEE
     LALKKPMAKC AWKGPREPPQ DARAEAESPG GASESDQDGG HESPPKKKAV AWVSAKNPAP
     MRKKKKVSLG PVSYVLVDSE DGRKKPVMPK KGPGSRREAS DQKAPRGQQP AEATASTSRG
     PKAKPEGSPR RATNESRKV
//