ID KTN1_HUMAN STANDARD; PRT; 1357 AA. AC Q86UP2; Q13999; Q14707; Q15387; Q86W57; DT 15-SEP-2003 (Rel. 42, Created) DT 15-SEP-2003 (Rel. 42, Last sequence update) DT 15-SEP-2003 (Rel. 42, Last annotation update) DE Kinectin (Kinesin receptor) (CG-1 antigen). GN KTN1 OR CG1 OR KIAA0004. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. (ISOFORM 1). RC TISSUE=Lymphoid; RX MEDLINE=95306853; PubMed=7787243; RA Fuetterer A., Kruppa G., Kraemer B., Lemke H., Kroenke M.; RT "Molecular cloning and characterization of human kinectin."; RL Mol. Biol. Cell 6:161-170(1995). RN [2] RP SEQUENCE FROM N.A. (ISOFORM 2). RC TISSUE=Peripheral blood lymphocytes; RX MEDLINE=94314220; PubMed=8039706; RA Print C.G., Leung E., Harrison J.E.B., Watson J.D., Krissansen G.W.; RT "Cloning of a gene encoding a human leukocyte protein characterised by RT extensive heptad repeats."; RL Gene 144:221-228(1994). RN [3] RP SEQUENCE FROM N.A. (ISOFORM 1). RA Wang H.-C., Chen W.-F., Su Y.-R.; RT "Identification of a variant of Homo sapiens kinectin mRNA."; RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases. RN [4] RP SEQUENCE FROM N.A. (ISOFORM 2). RC TISSUE=Bone marrow; RX MEDLINE=96051387; PubMed=7584026; RA Nomura N., Miyajima N., Sazuka T., Tanaka A., Kawarabayashi Y., RA Sato S., Nagase T., Seki N., Ishikawa K.-I., Tabata S.; RT "Prediction of the coding sequences of unidentified human genes. I. RT The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by RT analysis of randomly sampled cDNA clones from human immature myeloid RT cell line KG-1."; RL DNA Res. 1:27-35(1994). RN [5] RP SEQUENCE FROM N.A. RX PubMed=12508121; RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., RA Sun H., Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., RA Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., RA Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., RA Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., RA Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., RA Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., RA Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., RA Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., RA Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., RA Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., RA Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., RA Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., RA Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., RA Quetier F., Waterston R., Hood L., Weissenbach J.; RT "The DNA sequence and analysis of human chromosome 14."; RL Nature 421:601-607(2003). RN [6] RP SEQUENCE OF 1-870 FROM N.A. (ISOFORMS 1/2). RC TISSUE=Lung; RX MEDLINE=22388257; PubMed=12477932; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). RN [7] RP SEQUENCE OF 191-195; 395-405; 545-554; 747-761 AND 811-823. RX MEDLINE=21969647; PubMed=11973345; RA Tran H., Pankov R., Tran S.D., Hampton B., Burgess W.H., Yamada K.M.; RT "Integrin clustering induces kinectin accumulation."; RL J. Cell Sci. 115:2031-2040(2002). RN [8] RP CHROMOSOMAL LOCATION. RX MEDLINE=96163023; PubMed=8575822; RA Print C.G., Morris C.M., Spurr N.K., Rooke L., Krissansen G.W.; RT "The CG-1 gene, a member of the kinectin and ES/130 family, maps to RT human chromosome band 14q22."; RL Immunogenetics 43:227-229(1996). CC -!- FUNCTION: Receptor for kinesin thus involved in kinesin-driven CC vesicle motility. Accumulates in integrin-based adhesion complexes CC (IAC) upon integrin aggregation by fibronectin. CC -!- SUBUNIT: Parallel homodimers formed between the membrane-bound and CC the cytosolic form, and also between 2 cytosolic forms (By CC similarity). CC -!- SUBCELLULAR LOCATION: Type II membrane protein. Vesicle membrane CC protein anchored to the endoplasmic reticulum. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Comment=Additional isoforms seem to exist; CC Name=1; CC IsoId=Q86UP2-1; Sequence=Displayed; CC Name=2; CC IsoId=Q86UP2-2; Sequence=VSP_007981, VSP_007982; CC -!- TISSUE SPECIFICITY: High levels in peripheral blood lympocytes, CC testis and ovary, lower levels in spleen, thymus, prostate, small CC intestine and colon. CC -!- SIMILARITY: Belongs to the kinectin family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; Z22551; CAA80271.1; -. DR EMBL; L25616; AAB65853.1; -. DR EMBL; AY264265; AAP20418.1; -. DR EMBL; D13629; BAA02794.1; -. DR EMBL; AL138499; -; NOT_ANNOTATED_CDS. DR EMBL; BC050555; AAH50555.1; ALT_TERM. DR PIR; S32763; S32763. DR PIR; I53799; I53799. DR Genew; HGNC:6467; KTN1. DR MIM; 600381; -. DR GO; GO:0005789; C:endoplasmic reticulum membrane; TAS. DR GO; GO:0005887; C:integral to plasma membrane; TAS. DR GO; GO:0005624; C:membrane fraction; TAS. DR GO; GO:0006899; P:nonselective vesicle transport; TAS. DR GO; GO:0007018; P:microtubule-based movement; ISS. KW Endoplasmic reticulum; Signal-anchor; Transmembrane; Coiled coil; KW Alternative splicing; Polymorphism. FT DOMAIN 1 6 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 7 29 SIGNAL-ANCHOR (TYPE II MEMBRANE PROTEIN) FT (POTENTIAL). FT DOMAIN 30 1357 ENDOPLASMIC RETICULUM (POTENTIAL). FT DOMAIN 330 1356 COILED COIL (POTENTIAL). FT CARBOHYD 172 172 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 435 435 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 772 772 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 904 904 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 1055 1055 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 1088 1088 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 1263 1263 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 1329 1329 N-LINKED (GLCNAC...) (POTENTIAL). FT VARSPLIC 1031 1059 Missing (in isoform 2). FT /FTId=VSP_007981. FT VARSPLIC 1232 1259 Missing (in isoform 2). FT /FTId=VSP_007982. FT VARIANT 282 282 V -> M (in dbSNP:2274073). FT /FTId=VAR_016206. FT CONFLICT 15 15 S -> P (IN REF. 4). FT CONFLICT 210 210 MISSING (IN REF. 1). FT CONFLICT 373 373 I -> M (IN REF. 1). FT CONFLICT 939 939 E -> G (IN REF. 1). SQ SEQUENCE 1357 AA; 156274 MW; 971FCDF8AA8FC88E CRC64; MEFYESAYFI VLIPSIVITV IFLFFWLFMK ETLYDEVLAK QKREQKLIPT KTDKKKAEKK KNKKKEIQNG NLHESDSESV PRDFKLSDAL AVEDDQVAPV PLNVVETSSS VRERKKKEKK QKPVLEEQVI KESDASKIPG KKVEPVPVTK QPTPPSEAAA SKKKPGQKKS KNGSDDQDKK VETLMVPSKR QEALPLHQET KQESGSGKKK ASSKKQKTEN VFVDEPLIHA TTYIPLMDNA DSSPVVDKRE VIDLLKPDQV EGIQKSGTKK LKTETDKENA EVKFKDFLLS LKTMMFSEDE ALCVVDLLKE KSGVIQDALK KSSKGELTTL IHQLQEKDKL LAAVKEDAAA TKDRCKQLTQ EMMTEKERSN VVITRMKDRI GTLEKEHNVF QNKIHVSYQE TQQMQMKFQQ VREQMEAEIA HLKQENGILR DAVSNTTNQL ESKQSAELNK LRQDYARLVN ELTEKTGKLQ QEEVQKKNAE QAATQLKVQL QEAERRWEEV QSYIRKRTAE HEAAQQDLQS KFVAKENEVQ SLHSKLTDTL VSKQQLEQRL MQLMESEQKR VNKEESLQMQ VQDILEQNEA LKAQIQQFHS QIAAQTSASV LAEELHKVIA EKDKQIKQTE DSLASERDRL TSKEEELKDI QNMNFLLKAE VQKLQALANE QAAAAHELEK MQQSVYVKDD KIRLLEEQLQ HEISNKMEEF KILNDQNKAL KSEVQKLQTL VSEQPNKDVV EQMEKCIQEK DEKLKTVEEL LETGLIQVAT KEEELNAIRT ENSSLTKEVQ DLKAKQNDQV SFASLVEELK KVIHEKDGKI KSVEELLEAE LLKVANKEKT VQDLKQEIKA LKEEIGNVQL EKAQQLSITS KVQELQNLLK GKEEQMNTMK AVLEEKEKDL ANTGKWLQDL QEENESLKAH VQEVAQHNLK EASSASQFEE LEIVLKEKEN ELKRLEAMLK ERESDLSSKT QLLQDVQDEN KLFKSQIEQL KQQNYQQASS FPPHEELLKV ISEREKEISG LWNELDSLKD AVEHQRKKNN DLREKNWEAM EALASTEKML QDKVNKTSKE RQQQVEAVEL EAKEVLKKLF PKVSVPSNLS YGEWLHGFEK KAKECMAGTS GSEEVKVLEH KLKEADEMHT LLQLECEKYK SVLAETEGIL QKLQRSVEQE ENKWKVKVDE SHKTIKQMQS SFTSSEQELE RLRSENKDIE NLRREREHLE MELEKAEMER STYVTEVREL KDLLTELQKK LDDSYSEAVR QNEELNLLKA QLNETLTKLR TEQNERQKVA GDLHKAQQSL ELIQSKIVKA AGDTTVIENS DVSPETESSE KETMSVSLNQ TVTQLQQLLQ AVNQQLTKEK EHYQVLE //