ID Q86TV8_HUMAN Unreviewed; 369 AA. AC Q86TV8; DT 01-JUN-2003, integrated into UniProtKB/TrEMBL. DT 01-JUN-2003, sequence version 1. DT 11-JUN-2014, entry version 56. DE SubName: Full=Full-length cDNA clone CS0DI031YK16 of Placenta of Homo sapiens (human); DE SubName: Full=Tyrosyl-DNA phosphodiesterase 1; GN Name=TDP1; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=12508121; DOI=10.1038/nature01348; RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., RA Sun H., Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., RA Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., RA Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., RA Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., RA Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., RA Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., RA Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., RA Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., RA Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., RA Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., RA Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., RA Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., RA Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., RA Quetier F., Waterston R., Hood L., Weissenbach J.; RT "The DNA sequence and analysis of human chromosome 14."; RL Nature 421:601-607(2003). RN [2] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Placenta; RA Li W.B., Gruber C., Jessee J., Polayes D.; RT "Full-length cDNA libraries and normalization."; RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Placenta; RA Genoscope; RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases. RN [4] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [5] RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2011) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL137128; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX161451; CAD61915.1; -; mRNA. DR UniGene; Hs.209945; -. DR ProteinModelPortal; Q86TV8; -. DR SMR; Q86TV8; 26-369. DR MaxQB; Q86TV8; -. DR Ensembl; ENST00000357382; ENSP00000349952; ENSG00000042088. DR UCSC; uc001xya.3; human. DR HGNC; HGNC:18884; TDP1. DR HOGENOM; HOG000147157; -. DR HOVERGEN; HBG067466; -. DR GO; GO:0005634; C:nucleus; IEA:InterPro. DR GO; GO:0008081; F:phosphoric diester hydrolase activity; IEA:InterPro. DR GO; GO:0006281; P:DNA repair; IEA:InterPro. DR Gene3D; 3.30.870.20; -; 1. DR InterPro; IPR010347; Tdp1. DR InterPro; IPR027415; TDP_C. DR PANTHER; PTHR12415; PTHR12415; 1. DR Pfam; PF06087; Tyr-DNA_phospho; 1. PE 1: Evidence at protein level; KW Complete proteome; Reference proteome. SQ SEQUENCE 369 AA; 41630 MW; 8674BAEED98FA149 CRC64; MVISERLRLT SMPRPSLTRT SLSARKMMLL LYEEGLRVVI HTSNLIHADW HQKTQGIWLS PLYPRIADGT HKSGESPTHF KADLISYLMA YNAPSLKEWI DVIHKHDLSE TNVYLIGSTP GRFQGSQKDN WGHFRLKKLL KDHASSMPNA ESWPVVGQFS SVGSLGADES KWLCSEFKES MLTLGKESKT PGKSSVPLYL IYPSVENVRT SLEGYPAGGS LPYSIQTAEK QNWLHSYFHK WSAETSGRSN AMPHIKTYMR PSPDFSKIAW FLVTSANLSK AAWGALEKNG TQLMIRSYEL GVLFLPSAFG LDSFKVKQKF FAGSQEPMAT FPVPYDLPPE LYGSKDRPWI WNIPYVKAPD THGNMWVPS //