ID Q85AE9_ECHMA PRELIMINARY; PRT; 361 AA. AC Q85AE9; DT 01-JUN-2003, integrated into UniProtKB/TrEMBL. DT 01-JUN-2003, sequence version 1. DT 21-FEB-2006, entry version 12. DE Cytochrome oxidase subunit I (Fragment). OS Echinometra mathaei (Rock boring urchin). OG Mitochondrion. OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; OC Echinoidea; Euechinoidea; Echinacea; Echinoida; Echinometridae; OC Echinometra. OX NCBI_TaxID=31178; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=MDm2, MDm3, MDm7, and MDm8; RX MEDLINE=22847123; PubMed=12964987; DOI=10.1098/rspb.2003.2395; RA Landry C., Geyer L.B., Arakaki Y., Uehara T., Palumbi S.R.; RT "Recent speciation in the Indo-West Pacific: rapid evolution of gamete RT recognition and sperm morphology in cryptic species of sea urchin."; RL Proc. R. Soc. Lond., B, Biol. Sci. 270:1839-1847(2003). CC -!- FUNCTION: Cytochrome c oxidase is the component of the respiratory CC chain that catalyzes the reduction of oxygen to water. Subunits 1- CC 3 form the functional core of the enzyme complex. CO I is the CC catalytic subunit of the enzyme. Electrons originating in CC cytochrome c are transferred via the copper A center of subunit 2 CC and heme A of subunit 1 to the bimetallic center formed by heme A3 CC and copper B (By similarity). CC -!- CATALYTIC ACTIVITY: 4 ferrocytochrome c + O(2) = 4 ferricytochrome CC c + 2 H(2)O. CC -!- PATHWAY: Respiratory chain; terminal step. CC -!- SUBCELLULAR LOCATION: Mitochondrion; mitochondrial inner membrane; CC multi-pass membrane protein (By similarity). CC -!- SIMILARITY: Belongs to the heme-copper respiratory oxidase family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY262912; AAP31634.1; -; Genomic_DNA. DR EMBL; AY262913; AAP31635.1; -; Genomic_DNA. DR EMBL; AY262915; AAP31637.1; -; Genomic_DNA. DR EMBL; AY262916; AAP31638.1; -; Genomic_DNA. DR SMR; Q85AE9; 1-361. DR GO; GO:0016021; C:integral to membrane; IEA. DR GO; GO:0016020; C:membrane; IEA. DR GO; GO:0005746; C:mitochondrial electron transport chain; IEA. DR GO; GO:0005739; C:mitochondrion; IEA. DR GO; GO:0019866; C:organelle inner membrane; IEA. DR GO; GO:0005507; F:copper ion binding; IEA. DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA. DR GO; GO:0016491; F:oxidoreductase activity; IEA. DR GO; GO:0006118; P:electron transport; IEA. DR InterPro; IPR000883; COX1. DR PANTHER; PTHR10422; COX1; 1. DR Pfam; PF00115; COX1; 1. DR PRINTS; PR01165; CYCOXIDASEI. DR PROSITE; PS50855; COX1; 1. KW Copper; Electron transport; Heme; Inner membrane; Membrane; KW Mitochondrion; Oxidoreductase; Respiratory chain; Transmembrane; KW Transport. FT NON_TER 1 1 FT NON_TER 361 361 SQ SEQUENCE 361 AA; 39192 MW; D1082528B56F0693 CRC64; VGTAMSVIIR AELAQPGSLL NDDQIYNXVV TAHALVMIFF MVMPIMIGGF GNWLIPLMIG APDMAFPRMN NMSFWLVPPS FILLLASAGV ESGAGTGWTI YPPLSSNIAH AGGSVDLAIF SLHLAGASSI LASINFITTI INMRTPGMSF DRLPLFVWSV FVTAFLLLLS LPVLAGAITM LLTDRNINTT FFDPAGGGDP ILFQHLFXXX XHPEVYILIL PGFGMISHVI AHYSGKREPF GYLGMVYAMI AIGVLGFLVW AHHMFTVGMD VDTRAYFTAA TMIIAVPTGI KVFSWMATLQ GSNLQWETPL FWALGFVFLF TLGGLTGIVL ANSSIDVVLH DTYYVVAHFH YVLSMGAVFA I //